2003
DOI: 10.3171/spi.2003.99.3.0271
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Low-dose radiotherapy for the inhibition of peridural fibrosis after reexploratory nerve root decompression for postlaminectomy syndrome

Abstract: Object. The authors of clinical studies have demonstrated a significant association between the presence of extensive post—lumbar discectomy peridural scar formation and the recurrence of low-back and radicular pain. Low-dose perioperative radiotherapy has been demonstrated to inhibit peridural fibrosis after laminectomy in animal models. The present study was designed to evaluate the clinical efficacy of preoperative irradiation in patients with fai… Show more

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Cited by 19 publications
(18 citation statements)
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“…Four RCTs 68,73,89,99 had used both adequate randomisation and allocation concealment (comparators included exercise therapy, intraoperative interventions and usual care). A further eight studies 81,[85][86][87][88]101,106,107 used adequate randomisation, but not allocation concealment (although two studies 87,106 used sealed envelopes), and one study 69 used adequate allocation concealment, but not randomisation. Two studies 91,93 used sealed envelopes, but gave no further details on method of randomisation.…”
Section: Summary Of Study Participants For Disc Surgerymentioning
confidence: 99%
“…Four RCTs 68,73,89,99 had used both adequate randomisation and allocation concealment (comparators included exercise therapy, intraoperative interventions and usual care). A further eight studies 81,[85][86][87][88]101,106,107 used adequate randomisation, but not allocation concealment (although two studies 87,106 used sealed envelopes), and one study 69 used adequate allocation concealment, but not randomisation. Two studies 91,93 used sealed envelopes, but gave no further details on method of randomisation.…”
Section: Summary Of Study Participants For Disc Surgerymentioning
confidence: 99%
“…Epidural injections and injections on the nervous roots had been also very studied and they do not present good results 23,24 . A study defends the preoperative irradiation for reoperation after epidural fibrosis with favorable results 25 , as also exist experiments with synthetic materials for the prevention of fibrosis 26,27 . The surgery is more indicated for the root compression processes and for column instability, because in other diseases the answers are not so satisfactory.…”
Section: Discussionmentioning
confidence: 99%
“…Reoperation for failed back syndrome is usually unsuccessful and might cause surgical complications 8 . Non steroidal anti-inflammatory drugs (NSAIDs) 15 , Gelfoam 27 , Goretex 22,25 , carboxymethil cellulose 33 , Adcon-L 11,21 , autogenous adipose grefting 13 , mitomisin 10 , and radiotherapy 12 have been investigated as potential treatments for the prevention of scar formation after spine surgery in the last decades. Most studies provide only a qualitative evaluation of the scar formation after laminectomy therefore it is difficult to make comparisons among the different agents.…”
Section: Introductionmentioning
confidence: 99%
“…Several materials have been tested as barriers to reduce the extent of peridural fibrosis [10][11][12][13]15,25,27,32,33 . None of the barrier materials have been universally accepted for this use 1 .…”
Section: Introductionmentioning
confidence: 99%