Low‐dose radiotherapy for multicystic benign lymphoepithelial lesions of the parotid gland in HIV‐positive patients: Long‐term results

Beitler, Jonathan J.; Bhatia, Vikram; Silver, Carl E.; Rubin, John S.; Bello, Jacqueline A.; Mitnick, Robin J.; Gejerman, Glen; Davis, Lawrence W.

doi:10.1002/hed.2880170107

Cited by 34 publications

(34 citation statements)

References 10 publications

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“…Unfortunately, the duration of the response after low-dose radiotherapy is usually not very long and a second course of radiation is rarely effective. Beitler et al [1] treated 15 patients with high-dose radiotherapy (18-24 Gy delivered in 1.5 Gy daily fractions) and compared them with a former study population that received low-dose radiotherapy (10 Gy, in 2 Gy daily fractions). The follow-up of these 15 patients was more than 2 years.…”

Section: Discussionmentioning

confidence: 99%

Management of benign lymphoepithelial lesions of the parotid gland in human immunodeficiency virus-positive patients

Kooper

Leemans

Hulshof

et al. 1998

European Archives of Oto-Rhino-Laryngology

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The diagnosis and radiotherapeutic treatment of these HIV-associated benign lymphoepithelial lesions in the parotid gland are discussed. As an example of these lesions, a case is presented involving a 43-year-old HIV-infected man with a 2-year history of enlargements in both parotid glands. After evaluation by computer tomography and cytology, the diagnosis of benign lymphoepithelial lesions was made. Treatment by low-dose radiotherapy (15 Gy) caused regression of both lesions. The lesion on the left regressed completely, but the one on the right side responded only partially. A second course of high-dose radiotherapy (24 Gy) to the right lesion caused regression to a cosmetically acceptable size.

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Section: Discussionmentioning

confidence: 99%

Management of benign lymphoepithelial lesions of the parotid gland in human immunodeficiency virus-positive patients

Kooper

Leemans

Hulshof

et al. 1998

European Archives of Oto-Rhino-Laryngology

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“…BLEC has two hypothesized etiologic mechanisms. The first theorized pathogenesis of BLEC is the “obstructive theory” which states that lymphoid proliferation in the parotid gland leads to ductal obstruction and salivary dilation that mimics a true cyst 1,3,4,7–9. The second hypothesized theory is that HIV-related reactive lymphoproliferation occurs in the lymph nodes of the parotid gland.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Fine-needle aspiration biopsy of BLEC results in clear, proteinaceous (straw-colored) fluid, with a mixture of epithelial (squamous) and benign lymphoid cells 7,10. This combination of history, physical examination, and fine-needle aspiration biopsy is diagnostic for BLEC 3,10…”

Section: Literature Reviewmentioning

confidence: 99%

“…Worse, after initial failure, retreatment of eight patients with 8–10 Gray produced fewer responses and no long-term local control 18. In 1999, Beitler et al studied 20 patients with BLEC, each treated with 18–24 Gray of radiation therapy to the parotid glands 3. They were able to demonstrate partial cosmetic control of the disease in 14 of 20 patients.…”

Section: Literature Reviewmentioning

confidence: 99%

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Benign lymphoepithelial cysts of the parotid: long-term surgical results

Steehler¹,

Steehler²,

Davison³

2012

HIV

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Benign lymphoepithelial cysts are a widely recognized cause of parotid gland swelling in patients infected with the human immunodeficiency virus (HIV). These cysts are pathognomonic for HIV. The cysts frequently grow to be exceptionally large, causing physical deformity and gross asymmetry of facial contour. This clinical commentary analyzes this cosmetically deforming disease entity and the many treatments that accompany it. The patient presented in this paper is a surgical case-control. The case is a microcosm for our findings upon review of the literature. Treatment options for benign lymphoepithelial cysts include repeated fine-needle aspiration and drainage, surgery, radiotherapy, sclerotherapy, and conservative therapy, with institution of highly active antiretroviral therapy medication. Based on this surgical case-control and our review of the literature, it is concluded that surgical intervention offers the best cosmetic result for these patients.

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“…Very low dose radiation can provide reliable but temporary palliation in parotid disease. 2 The diagnosis should be based on cytologic findings, in the context of consistent clinical and radiologic data and, whenever possible, supported by complementary methods. This case had unique features and probably represented an AIDS-related lesion and distinct entity.…”

Section: A B Acta Cytologicamentioning

confidence: 99%

Multicystic Autoimmune Thyroiditis–like Disease Associated with HIV Infection

Mitteldorf¹,

Misiara²,

Carvalho³

1999

Acta Cytologica

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Low‐dose radiotherapy for multicystic benign lymphoepithelial lesions of the parotid gland in HIV‐positive patients: Long‐term results

Abstract: Very low-dose radiation (8-10 Gy) provides reliable but temporary cosmetic palliation for BLL. Retreatment was unsatisfactory, and we are now investigating higher initial doses of radiation to prolong palliation and eliminate recurrences.

Cited by 34 publications

References 10 publications

Management of benign lymphoepithelial lesions of the parotid gland in human immunodeficiency virus-positive patients

Management of benign lymphoepithelial lesions of the parotid gland in human immunodeficiency virus-positive patients

Benign lymphoepithelial cysts of the parotid: long-term surgical results

Multicystic Autoimmune Thyroiditis–like Disease Associated with HIV Infection

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