Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA

Li, Y; Xu, Feng; Hui, Rutai; Huang, Heyu; Wang, Yu; Yu, Shui

doi:10.1007/s10517-021-05095-6

Cited by 17 publications

(9 citation statements)

References 9 publications

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“…Chronic fatigue is often accompanied by a poor quality of sleep. In patients with insomnia and cardiovascular disease, low-dose ozone therapy substantially alleviated depression, anxiety, and sleep quality in a mechanism mediated by the increase in serum BDNF and GABA [ 140 ]. As the same symptomatology is shared with PASC, it would be interesting to see if similar results could be obtained in the context of PASC.…”

Section: The Role Of Ozone In the Mito-hormetic Machinerymentioning

confidence: 99%

The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy

et al. 2022

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An increasing body of evidence in the literature is reporting the feasibility of using medical ozone as a possible alternative and adjuvant treatment for COVID-19 patients, significantly reducing hospitalization time, pro-inflammatory indicators, and coagulation markers and improving blood oxygenation parameters. In addition to the well-described ability of medical ozone in counteracting oxidative stress through the upregulation of the main anti-oxidant and scavenging enzymes, oxygen–ozone (O2–O3) therapy has also proved effective in reducing chronic inflammation and the occurrence of immune thrombosis, two key players involved in COVID-19 exacerbation and severity. As chronic inflammation and oxidative stress are also reported to be among the main drivers of the long sequelae of SARS-CoV2 infection, a rising number of studies is investigating the potential of O2–O3 therapy to reduce and/or prevent the wide range of post-COVID (or PASC)-related disorders. This narrative review aims to describe the molecular mechanisms through which medical ozone acts, to summarize the clinical evidence on the use of O2–O3 therapy as an alternative and adjuvant COVID-19 treatment, and to discuss the emerging potential of this approach in the context of PASC symptoms, thus offering new insights into effective and safe nonantiviral therapies for the fighting of this devastating pandemic.

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Section: The Role Of Ozone In the Mito-hormetic Machinerymentioning

confidence: 99%

The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy

et al. 2022

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“…Therefore, they believed that the elevated occipital GABA levels in insomnia disorder patients may reflect an allogeneic response to chronic hyperarousal (21). Furthermore, some researchers improved the sleep quality of patients with insomnia disorder by increasing the content of peripheral blood GABA (22)(23)(24)(25). However, we know little about the changes of peripheral blood GABAergic system in patients with untreated insomnia disorder.…”

Section: Introductionmentioning

confidence: 99%

Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system

Xiang

Liao²,

Cai³

et al. 2023

Front. Psychiatry

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AimTo explore the change characteristics and related factors of various indexes of GABAergic system in peripheral blood of patients with insomnia disorder.MethodsIn this study, a total of 30 patients who met the DSM-5 diagnostic criteria for insomnia disorder and 30 normal controls were included. All subjects had a structured clinical interview with the Brief International Neuropsychiatric Disorder Interview, and PSQI was used to evaluate the sleep status of the subjects. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum γ-aminobutyric acid (GABA), and RT-PCR was used to detect GABAA receptor α1 and α2 subunit mRNA. All data were statistically analyzed using SPSS 23.0.ResultsCompared with the normal control group, the mRNA levels of GABAA receptor α1 and α2 subunits in the insomnia disorder group were significantly lower, but there was no significant difference in the serum GABA levels between the two groups. And in the insomnia disorder group, there was no significant correlation between the GABA levels and the mRNA expression levels of α1 and α2 subunits of GABAA receptors. Although no significant correlation was found between PSQI and serum levels of these two subunit mRNAs, its component factors sleep quality and sleep time were negatively correlated with GABAA receptor α1 subunit mRNA levels, and daytime function was inversely correlated with GABAA receptor α2 subunit mRNA levels.ConclusionThe inhibitory function of serum GABA in patients with insomnia may be impaired, and the decreased expression levels of GABAA receptor α1 and α2 subunit mRNA may become a reliable indicator of insomnia disorder.

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“…Currently, several ozone‐related medical agents have been examined, developed, and employed to circumvent contraindications, including hyperthyroidism, hemorrhagic or coagulation dysfunction, glucose‐6‐phosphatase‐α (G6Pase‐α or G6PC) deficiency, or ozone allergy 3 . Ozone therapy has been widely used in more than 50 pathological processes, including skin diseases, intervertebral disc herniation, 4 diabetic complications, 5 oral mucosal diseases, cardiovascular and cerebrovascular diseases, 6 and cancer. In terms of skin diseases, topical ozone therapy can be employed to treat infectious skin diseases (e.g., tinea capitis and herpes zoster), 7,8 inflammatory skin diseases (e.g., eczema, psoriasis, atopic dermatitis, and contact dermatitis), 9‐11 autoimmune‐related skin diseases (e.g., pemphigus, bullous pemphigoid, and dermatomyositis) 12,13 and chronic ulcers (e.g., diabetic foot and pressure ulcers) 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Ozone therapy for skin diseases: Cellular and molecular mechanisms

Liu

Zeng

Gao

et al. 2022

International Wound Journal

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Ozone is a highly reactive oxidant molecule consisting of triatomic oxygen atoms. Ozone therapy can be achieved using ozonated hydrotherapy, ozonated oil, ozone autohemotherapy, and other innovative dosage forms of ozone products. Ozone is frequently used as a complementary therapy for various cutaneous diseases, including infectious skin diseases, wound healing, eczema, dermatitis, psoriasis, axillary osmidrosis, diabetic foot, and pressure ulcers. In addition, several studies have reported the superior potential of ozone therapy for improving skin and gut microbiomes, as well as antitumour and antiaging treatment. Ozone therapy is an emerging treatment strategy that acts via complex mechanisms, including antioxidant effects, immunomodulatory capacity, and modulation of local microcirculation. Studies assessing the mechanism of ozone have gradually expanded in recent years. This review article aims to summarise and explore the possible molecular biological mechanisms of ozone in cutaneous diseases and provide compelling theoretical evidence for the application of ozone in cutaneous diseases.

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Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA

Cited by 17 publications

References 9 publications

The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy

The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy

Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system

Ozone therapy for skin diseases: Cellular and molecular mechanisms

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