Low‐dose oral minoxidil improves global hair density and length in children with loose anagen hair syndrome

Jerjen, Rebekka; Koh, Wei Liang; Sinclair, Rodney; Bhoyrul, Bevin

doi:10.1111/bjd.19756

Cited by 19 publications

(20 citation statements)

References 6 publications

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“…In addition, a recently published systematic review [ 4 ] addressed the issue of minoxidil and children, finding only reports of topical minoxidil in children and one report of low-dose oral minoxidil in a 11-years-old female. To the best of our knowledge, apart from a recent study, which addressed the treatment with low-dose oral minoxidil in children with loose anagen hair syndrome [ 19 ], there is a lack of evidence of the use of oral minoxidil in children.…”

Section: Discussionmentioning

confidence: 99%

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Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects

Sánchez‐Díaz

López-Delgado

Montero‐Vílchez

et al. 2021

JCM

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Oral minoxidil is an approved treatment for high blood pressure which is also used as an off-label drug for alopecia. Knowledge about the effects of systemic minoxidil in the paediatric population is limited. A retrospective case series study of paediatric patients with history of systemic minoxidil intake due to contaminated sets of omeprazole was performed to describe side effects of high dose oral minoxidil intake in children. Twenty patients aged between 2 months and 13 years joined the study. They had received high doses of oral minoxidil (mean dose 0.90 mg/kg/day) during a mean time of 38.3 days. Hypertrichosis appeared in 65%, with a mean latency time of 24.31 days. Treatment time was associated with the appearance of hypertrichosis (p < 0.05). Most common initial zone of hypertrichosis was the face. Systemic effects developed in 15%, with no cases of severe disorders. The present study shows a novel insight into the side effects of high doses of oral minoxidil in children.

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Section: Discussionmentioning

confidence: 99%

“…It may be increase up to 1 mg/kg/day depending on the tolerance and effectiveness of the treatment [ 15 , 20 ]. When used to treat loose anagen hair syndrome [ 19 ], dose administered was lower than 0.02mg/kg/day. Severe adverse events seem to be dose-dependent, with a positive gradient [ 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects

Sánchez‐Díaz

López-Delgado

Montero‐Vílchez

et al. 2021

JCM

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“…Recently, small descriptive case series have evaluated low-dose OM for loose anagen hair syndrome,[ 24 ] androgenetic alopecia, and telogen effluvium in pediatric patients with promising results; nevertheless, bigger studies are needed to better understand safety and efficacy among this age group. [ 25 ] Knowledge about the effects and safety of low-dose OM in pediatric patients is limited; a 2-year-old boy who accidentally ingested 100 mg of OM in a single dose recovered fully after developing a transient reflex tachycardia.…”

Section: Special Considerations: Pediatric Patientsmentioning

confidence: 99%

Role of oral minoxidil in patterned hair loss

Ramírez-Marín

Tosti

2022

Indian Dermatol Online J

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Recent studies have shown that low-dose oral minoxidil (OM) can be a safe and effective treatment of numerous hair disorders including male-patterned hair loss (MPHL) and female-patterned hair loss (FPHL). There are several practical advantages of OM over its topical formulation: enhanced cosmesis, cost-savings, and the possibility of co-therapy with other topical formulations or topicals used for camouflage. This treatment may be particularly helpful for patients who are unable to tolerate topical minoxidil or other systemic treatments. Doses ranging from 0.25 to 1.25 mg daily are usually used for FPHL and doses ranging from 2.5 to 5 mg/day for MPHL. The low side-effect profile of low-dose OM allows for long-term adherence to the medication and favorable clinical response, resulting in stabilization and improvement of hair loss. More studies are needed to test the efficacy of OM in other types of alopecia as well as additional comparative studies assessing OM to other commonly used medications.

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“…1 Spontaneous resolution was observed within 24 months, with recovery of normal hair, but minoxidil might be used in future. 2…”

mentioning

confidence: 99%

“…A predominance of anagen hairs without inner root sheaths is usually observed 1 . Spontaneous resolution was observed within 24 months, with recovery of normal hair, but minoxidil might be used in future 2 …”

mentioning

confidence: 99%

Loose anagen hair syndrome: take a closer look!

Pottier¹,

Eymieux

Blanchard‐Laumonnier

et al. 2022

British Journal of Dermatology

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DEAR EDITOR, A girl aged 35 months presented hair lightening and reduced hair growth over a period of 1 year. Examination demonstrated reduced hair of unequal length (a); trichoscopy results were normal. The hair pull test was positive and painless by epilating unanchored anagen hairs. Scanning electronic microscopy revealed longitudinal grooves; bulbs shaped like golf clubs (b); fishhook-like bulbs (c) and a ruffled cuticle resembling a 'crumpled sock' (marked * in panel c). A diagnosis of loose anagen hair syndrome was established. A predominance of anagen hairs without inner root sheaths is usually observed. 1 Spontaneous resolution was observed within 24 months, with recovery of normal hair, but minoxidil might be used in future. 2

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Low‐dose oral minoxidil improves global hair density and length in children with loose anagen hair syndrome

Cited by 19 publications

References 6 publications

Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects

Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects

Role of oral minoxidil in patterned hair loss

Loose anagen hair syndrome: take a closer look!

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