Low Dose of β-Carotene Regulates Inflammation, Reduces Caspase Signaling, and Correlates with Autophagy Activation in Cardiomyoblast Cell Lines

Lesmana, Ronny; Yusuf, Inez Felia; Goenawan, Hanna; Achadiyani, Achadiyani; Khairani, Astrid Feinisa; Fatimah, Siti; Supratman, Unang

doi:10.12659/msmbr.928648

Cited by 7 publications

(9 citation statements)

References 48 publications

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“…β-Carotene functions as provitamin A and acts as a cytoprotective antioxidant by scavenging lipid radicals and quenching a singlet oxygen [49]. Supplementation with low doses of β-carotene can produce bene cial effects on cardiomyoblasts by reducing in ammation by suppressing nuclear factor-kappa B and increasing Nrf2 levels, stimulating autophagy, and suppressing apoptosis [50]. Intriguingly, Zhou et al [51], investigating rats with spinal cord injury, observed that β-carotene treatment relieved oxidative stress via the regulation of reactive oxygen species, MDA, nitric oxide, and superoxide dismutase and restored the levels of Nrf2 and heme oxygenase-1.…”

Section: Discussionmentioning

confidence: 99%

Effects of Riceberry rice bran oil supplementation on oxidative stress, cardiovascular risk biomarkers, and cardiac autonomic nervous system activity in older adults with prehypertension

Prasertsri

Boonla

Vierra

et al. 2022

Preprint

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Background In this study, we aimed to measure the changes in the biomarkers of oxidative stress, cardiovascular disease risk, and the activity of the cardiac autonomic nervous system in older adults with prehypertension after supplementation with Riceberry rice bran oil. Methods In total, 35 women aged 60–76 years with prehypertension were randomly allocated to two groups, one of which was supplemented with rice bran oil (n = 18) and the other with Riceberry rice bran oil (n = 17) at 1,000 mg (500 mg × 2 capsules) daily for 8 weeks. The primary outcomes, including oxidative stress and cardiovascular risk biomarkers, and secondary outcomes, including heart rate variability and blood pressure, were determined before and after the 8-week supplementation. Results The levels of plasma malondialdehyde, blood glutathione disulfide, and tumor necrosis factor-alpha were significantly decreased, and the ratio of reduced glutathione to glutathione disulfide significantly increased in both groups after supplementation (all p < 0.05). No significant differences were noted between groups. Heart rate variability and blood pressure were not statistically significantly different after supplementation in both groups. Conclusions Supplementation with Riceberry rice bran oil for 8 weeks may attenuate oxidative stress and inflammation in older adults with prehypertension. The effects of a longer supplementation period or use in hypertensive persons should be further investigated, especially with regard to blood pressure and cardiac autonomic nervous system activity. Trial registration: This trial was registered March 22, 2019 at https://www.thaiclinicaltrials.org as TCTR20190322002.

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Section: Discussionmentioning

confidence: 99%

Effects of Riceberry rice bran oil supplementation on oxidative stress, cardiovascular risk biomarkers, and cardiac autonomic nervous system activity in older adults with prehypertension

Prasertsri

Boonla

Vierra

et al. 2022

Preprint

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“…The mechanisms underlying these effects were linked to the inhibition of the activation of NF-κB, activator protein-1 (AP-1), and signal transducer and activator of transcription 3 (STAT3) transcription factors [125]. In the same line, the cardioprotective role of a low dose of β-carotene in the prevention of ROS-induced atherosclerosis has been reported in cardiomyoblasts through up-regulation of Nrf2, activation of autophagy, and inhibition of NF-κB and apoptosis [126].…”

Section: β-Carotene 411 In Vitro Studiesmentioning

confidence: 92%

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

et al. 2021

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Acute inflammation is a key component of the immune system’s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as α- and β-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, α- and β-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.

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“…Carotenoids have potent antioxidant, anti-inflammatory, and immunomodulatory abilities. (34) β-carotene is the most common carotenoid, which is also known as pro-vitamin A, and is one of the most abundant carotenoids in the human blood with several health-promoting properties (35,36). The anti-inflammatory effects of β-carotene have been demonstrated in multiple systems (37,38).…”

Section: Potential Role Of β-Carotene-modulated Autophagy In Puerpera...mentioning

confidence: 99%

“…As an antioxidant, β-carotene suppresses intracellular ROS production and reduces antioxidative enzyme activity (36,41,42). Β-carotene supplementation exerts a stabilizing effect on polymorphonuclear cells such as neutrophils, eosinophils, and basophils, and optimizes lymphocyte function (23).…”

Section: Potential Role Of β-Carotene-modulated Autophagy In Puerpera...mentioning

confidence: 99%

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Potential role of β‑carotene‑modulated autophagy in puerperal breast inflammation (Review)

et al. 2022

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Puerperal breast inflammation is common in the first 6-8 weeks postpartum, and without proper management, may lead to a decrease in breastmilk production and early cessation of breastfeeding. Recent studies showed that carotenoids decrease the severity of puerperal breast inflammation. This article summarizes the significant findings on β-carotene with a potential role as an autophagy modulator in puerperal breast inflammation. Puerperal milk stasis causes an increase in inflammatory cytokines and inflammatory cells, leading to reactive oxygen species (ROS) activation that causes oxidative damage to mammary glands and affects breast milk secretion. β-carotene has an anti-inflammatory effect related to its ROS-scavenging activity and modulates autophagy, thus stimulating the removal of damaged cellular structures and supporting milk gland survival. β-carotene modulates autophagy through phosphorylation of NF-κB, JNK, p38, Akt, and Nrf2, affects the ratio of Microtubule-associated protein 1A/1B-light chain 3 (LC3)-II/LC3-I, and has a role in the regulation of the JAK2/STAT3, PI2K/Akt/mTOR and AMPK pathways. Although the in vitro and in vivo studies showed promising results, further studies on humans are required to better conclude the potential role of β-carotene in managing puerperal breast inflammation.

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Low Dose of β-Carotene Regulates Inflammation, Reduces Caspase Signaling, and Correlates with Autophagy Activation in Cardiomyoblast Cell Lines

Cited by 7 publications

References 48 publications

Effects of Riceberry rice bran oil supplementation on oxidative stress, cardiovascular risk biomarkers, and cardiac autonomic nervous system activity in older adults with prehypertension

Effects of Riceberry rice bran oil supplementation on oxidative stress, cardiovascular risk biomarkers, and cardiac autonomic nervous system activity in older adults with prehypertension

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

Potential role of β‑carotene‑modulated autophagy in puerperal breast inflammation (Review)

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