Low dose of quercetin-loaded pectin/casein microparticles reduces the oxidative stress in arthritic rats

Quercetin improves the protection of hydroxysafflor yellow a against cerebral ischemic injury by modulating of blood-brain barrier and src-p-gp-mmp-9 signalling

“…Secondly, it will be useful to improve the bioavailability of Quer through the design of drug delivery systems, modification of drug formulations and their applications. Quer aglycone [ 35 ] and Quer stabilized by microencapsulation with pectin/casein polymers [ 36 ] are two examples. Quer in its nano formulations is another way to enhance bioavailability and pharmacological effects [ 27 ].…”

Alpha-tocopherol-loaded polycaprolactone nanoparticles improve the inflammation and systemic oxidative stress of arthritic rats

“…In addition to polyarthritis, the animal model used in the present study also develops intense cachexia and presents a pronounced systemic oxidative stress that affects other organs, such as liver and brain. 11 , 45 The more pronounced effectiveness found with a lower dose of intraperitoneally injected α-tocopherol (100 mg kg −1 ) is probably associated with the route of administration, which allows enhanced delivery and corporeal distribution of compounds when compared to the subcutaneous route. 42 In fact, when intraperitoneally administered, the content of α-tocopherol was substantially increased in both liver and brain.…”

“…This occurs in consequence of both a stimulated pro-oxidant system and a deficient antioxidant defense, with predominance of the latter as indicated by the strongly diminished activities of catalase and GSH levels. 10 , 11 , 45 Both phenomena seem to be caused by cytokines released into the synovium which may also reach the systemic circulation. 10 , 11 The levels of protein carbonyl groups were measured as markers of oxidative injury to proteins and FRAP and thiol groups were assayed as antioxidant markers in the plasma.…”

Quercetin in Drug Carriers: Polymer Composite, Physical Characteristics, and In vitro Study

“…Pectin-Reduce oxidative stress in arthritis-infected rats; (Souza et al, 2021) ; Casein enhancing drug release and stability. (Jing et al, 2023) Carnauba Wax Proved effective in flavor masking (Khor et al, 2017) Sodium Alginate High-bioavailability drug delivery; wrinkled (Hazra et al, 2015) ; -chitosan surface, compact structures, and thermal stability; (Frent , et al, 2022) ; enhanced quercetin bioactivity, increased (Frent et al, 2023) ; smoothness, and roughness; absorption of (Bhadraiah et al, 2023) albendazole and its active metabolite was enhanced…”