Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism

Miceli, Diego Daniel; Gallelli, María Florencia; Blatter, M.F. Cabrera; Martiarena, B.; Brañas, M. M.; Ortemberg, L.; Gomez, Nestor A.; Castillo, V.

doi:10.1016/j.rvsc.2011.07.003

Cited by 13 publications

(11 citation statements)

References 66 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In dogs treated for pituitary-dependent hypercortisolism with retinoic acid, the rate of progression from IFG (105-168 mg/dL [5.8-9.3 mmol/L]) to DM (BG > 168 mg/dL [9.3 mmol/L]) was significantly lower in those additionally treated with a low dosage of insulin detemir (0.1 U/kg q24h) as compared to those not treated with insulin. 63 This study lends support to the hypothesis that defining and treating subclinical dysglycemia could delay or prevent overt DM in dogs. It also suggests that low doses of insulin detemir are useful and safe in regulating glycemia in dogs with only mildly increased BG.…”

Section: The Importance Of Early and Accurate Diagnosis Of Mature-onssupporting

confidence: 72%

“…Does the difference lie in severity of or sensitivity to hypercortisolism, or does it lie in a primary pancreatic lesion that prevents adequate compensation for insulin resistance caused by glucocorticoids? If hypercortisolism merely exposes a pre‐existing pancreatic lesion (caused by any one the other etiologies of DM) in these dogs, then the prevalence of DM in dogs with hypercortisolism should be much more similar to the prevalence of DM in the general population . However, it is possible that hypercortisolism merely exposes a pre‐existing pancreatic lesion that would have otherwise remained subclinical.…”

Section: Dm Secondary To Endocrinopathies and Gestational Dm In Dogsmentioning

confidence: 99%

“…If hypercortisolism merely exposes a pre-existing pancreatic lesion (caused by any one the other etiologies of DM) in these dogs, then the prevalence of DM in dogs with hypercortisolism should be much more similar to the prevalence of DM in the general population. 41,63 However, it is possible that hypercortisolism merely exposes a pre-existing pancreatic lesion that would have otherwise remained subclinical.…”

Section: Dm Secondary To Hypercortisolism In Dogsmentioning

confidence: 99%

See 2 more Smart Citations

What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters

Gilor

Niessen

Furrow

et al. 2016

Veterinary Internal Medicne

122

139

View full text Add to dashboard Cite

Diabetes Mellitus (DM) is a syndrome caused by various etiologies. The clinical manifestations of DM are not indicative of the cause of the disease, but might be indicative of the stage and severity of the disease process. Accurately diagnosing and classifying diabetic dogs and cats by the underlying disease process is essential for current and future studies on early detection, prevention, and treatment of underlying disease. Here, we review the current etiology‐based classification of DM and definitions of DM types in human medicine and discuss key points on the pathogenesis of each DM type and prediabetes. We then review current evidence for application of this etiology‐based classification scheme in dogs and cats. In dogs, we emphasize the lack of consistent evidence for autoimmune DM (Type 1) and the possible importance of other DM types such as DM associated with exocrine pancreatic disease. While most dogs are first examined because of DM in an insulin‐dependent state, early and accurate diagnosis of the underlying disease process could change the long‐term outcome and allow some degree of insulin independence. In cats, we review the appropriateness of using the umbrella term of Type 2 DM and differentiating it from DM secondary to other endocrine disease like hypersomatotropism. This differentiation could have crucial implications on treatment and prognosis. We also discuss the challenges in defining and diagnosing prediabetes in cats.

show abstract

Section: The Importance Of Early and Accurate Diagnosis Of Mature-onssupporting

confidence: 72%

Section: Dm Secondary To Endocrinopathies and Gestational Dm In Dogsmentioning

confidence: 99%

Section: Dm Secondary To Hypercortisolism In Dogsmentioning

confidence: 99%

See 1 more Smart Citation

What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters

Gilor

Niessen

Furrow

et al. 2016

Veterinary Internal Medicne

122

139

View full text Add to dashboard Cite

show abstract

“…The efficacy of insulin detemir for the management of canine DM seems to be adequate and it may prove to be superior to other insulin types, although the risk of hypoglycemia may be increased (Sako et al, 2011;Maggiore et al, 2012), whereas in cats it appears to be comparable to insulin glargine when intensive protocols aiming to diabetic remission are employed (see later). An additional indication to use insulin detemir may be the prevention of DM in non-diabetic dogs with pituitary-dependent hyperadrenocorticism and mild hyperglycemia (>100 mf dl -1 ) but additional studies are needed to confirm the safety and efficacy of such as approach (Miceli et al, 2012).…”

Section: Types Of Insulin For Dogs and Cats With Non-complicated Diabmentioning

confidence: 99%

Update on insulin treatment of dogs and cats with non-complicated diabetes mellitus

Saridomichelakis

Chatzis

2018

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

ABSTRACT. Diabetes mellitus is a common endocrine disease of dogs and cats. Treatment is mainly based on insulin administration and dietary modifications. The aim of this review is to provide updated information on insulin treatment of dogs and cats with non-complicated diabetes mellitus. During the last years, there has been significant progress in the management of this disease, thanks to the use of long-acting insulin preparations that do not cause pronounced fluctuations of blood glucose concentrations (insulin glargin and detemir) and because of the widespread use of home glucose monitoring by the owners of diabetic pets. Home glucose monitoring is based on capillary blood sampling from the ear pinnae or the foot pad and measurement of blood glucose concentration with a portable blood glucose meter. This can be done periodically (e.g. every week) to replace the traditional in-clinic blood glucose curve; in this case, blood glucose concentration is measured just before the morning insulin administration and then every 1-2 hours until the next dose (usually for 12 hours). Furthermore, especially for the cat, home glucose monitoring can be performed 3-5 times per day, on a daily basis, in order to safely adjust insulin dose and achieve tight control of hyperglycemia (i.e. blood glucose concentration between 50 and 200 mg dl -1 throughout the day). The combination of dietary management, of insulin glargine or detemir administration and of the tight control of hyperglycemia has substantially increased the proportion of cats that enter into temporal or permanent diabetic remission and can be further managed without insulin. Another important achievement is the use of continuous glucose monitoring systems to monitor interstitial fluid glucose concentrations. These devices can be used in the clinic and at home and they can measure glucose concentration every 5 minutes for up to 72 consecutive hours, thus facilitating optimal adjustment of insulin treatment.

show abstract

“…En el último caso, la terapia con insulina favorece la disminución de los principales signos clínicos de la enfermedad (Miceli et al, 2012); a través de la regulación de la producción de citocinas proinflamatorias asociadas a la DM, previniendo adicionalmente alteraciones metabólicas como la cetoacidosis (O'Neill et al, 2012).…”

Section: Tratamiento De La Diabetes Sin Complicacionesunclassified

Diagnóstico y tratamiento de la diabetes mellitus en perros

2017

View full text Add to dashboard Cite

RESUMENLa diabetes mellitus (DM) es una enfermedad metabólica que frecuentemente se presenta en perros, que se caracteriza por niveles elevados de glucosa plasmática. En la actualidad, no existe ninguna clasificación de los distintos tipos de este padecimiento en perros. En humanos, puede clasificarse como: DM tipo I, tipo II y diabetes asociada a la gestación. En perros se utiliza la misma clasificación pero hay cuadros clínicos asociados al diestro y a la pancreatitis. En los perros se presenta el 50% de DM tipo I y el resto se agrupa entre la DM tipo II y los otros. Los principales signos clínicos que presentan los perros diabéticos son: poliuria, polidipsia, pérdida de peso, polifagia; menos frecuentemente es la hepatomegalia y las cataratas. Para realizar su diagnóstico se usan tres pruebas de laboratorio: hemograma, perfil bioquímico y uroanálisis. Al encontrar resultados positivos de hiperglucemia y glucosuria, el paciente será diagnosticado con DM. Entonces el médico veterinario le brindará al paciente un tratamiento adecuado basado en suministro de insulina, dieta balanceada y ejercicio constante. Por tal motivo, el objetivo de esta revisión bibliográfica es proporcionar información actualizada acerca de la DM, para estudiantes de medicina veterinaria y médicos veterinarios. Palabras clave: Perro, diabetes mellitus, insulina, glucosa. ABSTRACTDiabetes mellitus (DM) is a metabolic disease that often occurs in dogs. This is characterized by hyperglycemia in plasma. To date, it has not been developed a classification of different types of this disease in dogs, such as in humans. In humans, it can be classified as type I and type II DM, as well as gestational DM. In dogs, the same classification is used, but usually, there are some clinical symptoms of DM associated with diestrus and pancreatitis. 50% DM type I is diagnosed in dogs and less frequent type II DM and other. The main clinical signs in dogs are polyuria, polydipsia, weight loss, polyphagia and less common hepatomegaly and cataracts. For Laboratory diagnosis three tests are usually applied: blood count, biochemical profile and urinalysis. When positive results of hyperglycemia and glycosuria are found, the patient will be diagnosed with DM and veterinarian will provide an adequate treatment based on insulin therapy, balanced diet, and regular exercise. Therefore, the aim of this review is to provide basic and update information about DM for public, veterinary students, and veterinarians. Key words: Dog, diabetes mellitus, Insulin, Glucose. INTRODUCCIÓNEn la actualidad, la diabetes es una enfermedad que no solo afecta a los humanos, sino que también está presente en las mascotas; con sintomatología clínica similar al

show abstract

Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism

Cited by 13 publications

References 66 publications

What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters

What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters

Update on insulin treatment of dogs and cats with non-complicated diabetes mellitus

Diagnóstico y tratamiento de la diabetes mellitus en perros

Contact Info

Product

Resources

About