Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical data analysis of 9915 cases

Abstract

Background: Flurbiprofen axetil (FA) is a commonly prescribed agent to relieve perioperative pain, but the relationship between FA and postoperative acute kidney injury (AKI) remains unclear. This study attempted to evaluate the effects of different dose of perioperative FA on postoperative AKI. Methods: A total of 9915 patients were enrolled for this retrospective study. The clinical characteristics and the prevalence of postoperative AKI among patients non-using, using low dose (50-100 mg), middle dose (100-250 mg) and large dose (≧250 mg) of FA were analyzed respectively. The impact of different dose of FA on postoperative AKI was analyzed using univariable and multivariate logistic regression analysis. Results: The prevalence of postoperative AKI was 6.7% in the overall subjects and 5.1% in 2446 cases who used FA. The incidence of AKI in low dose group was significantly less than that of non use group (4.5% vs 7.2%, P < 0.001), but the incidence of AKI in large dose group was significantly higher than that in the nonuse group (18.8% vs 7.2%, P < 0.001). However, there was no significant difference between patients without using FA and subjects using middle dose of FA (7.2% vs 5.6%, p = 0.355). Multivariate logistic regression analysis showed that low dose of FA was a protective factor for postoperative AKI (OR = 0.75, p = 0.0188), and large dose of FA was a risk factor for postoperative AKI (OR = 4.8, p < 0.0001). Conclusions: The impact of FA on postoperative AKI was dose-dependent, using of low dose FA (50-100 mg) perioperatively may effectively reduce the incidence of postoperative AKI.

Perioperative Use of Flurbiprofen Axetil on Renal Function after Transurethral Prostatectomy: A Prospective Randomized Controlled Study

“…Although the above studies have shown that NSAIDs are toxic to the kidneys, their wide application in the perioperative period is not limited. The retrospective analysis of our team also found that the effect of flurbiprofen axetil on postoperative renal function is dosedependent in the perioperative period: 50-100 mg flurbiprofen axetil can reduce the incidence of AKI postoperatively, but there is obvious renal damage when it exceeds 250 mg [15]. To this end, we conducted a prospective study to verify whether low-dose flurbiprofen axetil has a protective effect on the kidney by detecting changes in Scr, Cystatin-C, NGAL, and other indicators during the perioperative period.…”

“…The decline of renal blood flow can cause renal ischemia to be further aggravated or renal tubular necrosis in the case of existing renal disease [11]. In a single-center retrospective study, it was found that compared with patients who did not use flurbiprofen axetil, patients who received 100 mg flurbiprofen axetil during the perioperative period had a lower incidence of AKI [15]. These studies have suggested that flurbiprofen axetil may have renal protection.…”

Effect of Lung Protective Ventilation Combined With Flurbiprofen Axetil on Immune Function During Thoracoscopic Radical Resection of Lung Cancer

“…It can reduce the dose of opioids, and is currently mainly used for cancer pain treatment, postoperative analgesia and preemptive analgesia et al ( 15 , 16 ). In addition, compared with tramadol or morphine, flurbiprofen had the weakest immunosuppressive effect during postoperative analgesia ( 17 ). Previous studies have indicated that postoperative analgesia with flurbiprofen axetil can alleviate postoperative immunosuppression, and protect the immune function of cancer patients ( 18 , 19 ).…”

Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis

“…Even more, a prospective and multicenter study by STARSurg showed that NSAIDs in the postoperative was safer for the patients undergoing gastrointestinal surgery. And the low dose of flurbiprofen axetil (50-100 mg) decrease the rate of AKI after non-cardiac surgery [25,26].…”