Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice

Genaro, Isabella Santos de; Almeida, Francine Maria de; Hizume-Kunzler, Deborah Camargo; Moriya, Henrique Takachi; Silva, Ronaldo Aparecido; Cruz, João Carlos Gonçalves; Lopes, Renan Boeira; Righetti, Renato Fraga; Saiki, M.; Martins, Mílton A.; Tibério, Iolanda de Fátima Lopes Calvo; Arantes-Costa, Fernanda M.; Saraiva-Romanholo, Beatriz Mangueira

doi:10.1038/s41598-018-30851-6

Cited by 12 publications

(14 citation statements)

References 72 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results demonstrated that inhibition of ROCK2 led to the reduction of mucus and cytokines secretion when CTNNAL1 was silenced. In addition, it has been reported that an increase in ROCK2 leads to mucus hypersecretion,49,50 which confirmed our results.Although ROCK1 and ROCK2 share more than 90% homology in their kinase domains, they had different expression when CTNNAL1 silenced. ROCK1 and ROCK2 might be regulated by different transcription factors when CTNNAL1 silenced.…”

supporting

confidence: 92%

CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway

Wang

Liu

et al. 2022

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

supporting

confidence: 92%

CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway

Wang

Liu

et al. 2022

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…In high-dose exposure, acids and free radicals damage the cell walls that interact with sulfhydryl groups in amino acids and enzyme systems in the mucosal epithelium. This causes edema, erosion, desquamation, and necrosis of epithelial cells [17][18][19].…”

Section: Resultsmentioning

confidence: 99%

The Smell Function Disturbance in Textile Industrial Workers Exposed to Chlorine Gas

Rianto

Purnomo

Sastrowijoto

2019

BJSTR

View full text Add to dashboard Cite

Objective: Nasal olfactory parts which exposed to toxic agents can cause smelling disturbance. Chlorine is a chemical substance commonly used in the textile industry, to which factory workers are exposed. Materials and Methods:This research design was an analytic cross-sectional study aimed to compare the smelling function between textile industrial workers exposed to chlorine gas and those not exposed. The subjects were industrial workers exposed to chlorine gas and those not exposed during January until February 2013. The inclusion criteria for the chlorine exposed group were: a) age 20-55 years, b) worked in chlorine exposed area, and c) agree to participate in the study, while the not exposed group worked in the free chlorine area. Exclusion criteria were: a. suffered from rhinitis, b. history of head and nose trauma, c. history of rhinoplasty, d. history of smoking, and e. suffered from nasal tumor.All samples smelled using camphora, carbon disulfide, vanilla, menthol piperate, ether, capsaicin as standard tool in odor-free rooms. The statistical analyses used X 2 tests.Results: There were 80 workers consisting 40 worker each group. From the exposed group found 10 (25%) with the smell function disturbance and 30 (75%) normal, while the unexposed group 2 (5%) the smell function disturbance and 38 (95%) normal. These results are statistically significant differences (p = 0.012; RP: 6.333; 95% CI: 1.289-31.115). Conclusion:There was a significant difference in smelling function disturbance between workers exposed to chlorine and those not exposed to chlorine.

show abstract

“…In addition, aqueous sodium hypochlorite solution is the most widely used irrigant in endodontic treatment for disinfecting root canals 33 . Exposure to disinfectants based on chlorine products, such as sodium hypochlorite, has been identified as a source of irritation and airway inflammation 34‐36 . In the current COVID‐19 situation, sodium hypochlorite is recommended as effective surface disinfectant 37 .…”

Section: Discussionmentioning

confidence: 99%

Respiratory symptoms of exposure to substances in the workplace among Bulgarian dentists

Stoeva

2020

Comm Dent Oral Epid

View full text Add to dashboard Cite

Objectives Dentists are exposed to a variety of airborne chemicals that can act as irritants and sensitizers and may give rise to work‐related respiratory symptoms. The aim of this study was to estimate the prevalence of respiratory symptoms of exposure to substances in the workplace and associated risk factors in Bulgarian dentists. Methods A cross‐sectional study was performed among Bulgarian dentists by using a self‐report questionnaire. A direct acyclic graph (DAG) was elaborated to illustrate the direct and indirect causal pathways between exposure to irritants and/or allergens from dental environment and work‐related respiratory symptoms among dentists. Multiple logistic regression analysis was conducted in order to investigate the relationship between sex, work experience, daily exposure to chemicals from dental environment, history of atopic disorder and work‐related respiratory symptoms. Results A total of 4675 dentists completed the questionnaire (response rate 48.1%). The prevalence of self‐reported work‐related respiratory symptoms was 20.7%. The most common repeated causes of respiratory reactions were disinfectants (65.7%) and materials based on acrylic resins (29.7%). Factors associated with work‐related respiratory symptoms are personal history of asthma (odds ratio (OR) 2.50, 95% confidence interval [CI]: 1.71‐3.64), work experience >20 years (OR 2.17, 95% CI: 1.74‐2.70) and female gender (OR 2.14, 95% CI: 1.81‐2.56). Conclusion Work‐related respiratory symptoms are frequent among dentists and indicate a need for efforts to establish effective programmes and techniques of reducing or eliminating direct exposure to airborne chemicals in the dental environment.

show abstract

Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice

Cited by 12 publications

References 72 publications

CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway

CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway

The Smell Function Disturbance in Textile Industrial Workers Exposed to Chlorine Gas

Respiratory symptoms of exposure to substances in the workplace among Bulgarian dentists

Contact Info

Product

Resources

About