Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster

Wu, Di; Zhang, Wenlong; Wang, Tingting; Lin, Tao; Jin, Xuemin; Xie, Xufeng; Guo, Jian; Cao, Yongguo; Wu, Rui

doi:10.1016/j.micpath.2016.11.018

Cited by 13 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a retrospective observational study, delayed initiation of antibiotics was associated with more severe disease [6]. Although some studies in hamsters have shown a statistically significant survival advantage in the group of animals treated with antibiotics [7,8], subtherapeutic use of norfloxacin and ciprofloxacin reduced the survival rate in hamsters infected with pathogenic Leptospira [10]. In C57BL/6 mice, live imaging of bioluminescent leptospires demonstrates that antibiotic treatment with penicillin, ciprofloxacin, and doxycycline is effective if administered early post-infection but failed to eliminate all the leptospires from the renal tubules during the chronic phase of leptospirosis [9].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic susceptibilities of livestock isolates of leptospira

Liégeon

Delory

Picardeau

2018

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

Leptospirosis is the most common zoonotic disease and is endemic worldwide. The antibiotic susceptibilities of Leptospira strains isolated from both humans and animals are poorly documented. This issue is particularly important for isolates from food-producing animals which are regularly exposed to antibiotic treatments. This study assessed the susceptibility of 35 leptospira strains isolated from food-producing animals of diverse geographical origins between 1936 and 2016 to the antimicrobial agents used most commonly in animals. A broth microdilution method was used to determine the susceptibilities of Leptospira strains isolated from livestock to 11 antibiotics. All isolates were susceptible to penicillin, amoxicillin, clavulanate, cephalexin, ceftriaxone, doxycycline, tetracycline, streptomycin, enrofloxacin and spectinomycin, but not polymyxin [minimum inhibitory concentration (MIC) ≥ 4 μg/L]. For tetracycline and doxycycline, the MIC was significantly higher for the recent isolates from Sardinia, Italy than for the other isolates. Antimicrobial susceptibilities were also determined with 10- and 100-fold higher inocula. High inocula significantly diminished the antibacterial effect by at least 10-fold for enrofloxacin (MIC ≥256 μg/L), streptomycin (MIC ≥16 μg/L) and tetracycline (MIC ≥32 μg/L), suggesting selection of resistant strains for high inocula. These findings contribute to the assessment of whether certain antibiotics are potentially useful for the treatment of leptospirosis, and point out the risk of failure for some antibiotics during infection with a high inoculum in both animals and humans. This study strengthens the need to detect and prevent the emergence of antimicrobial resistance of this major emerging zoonotic pathogen.

show abstract

Section: Introductionmentioning

confidence: 99%

Antibiotic susceptibilities of livestock isolates of leptospira

Liégeon

Delory

Picardeau

2018

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

show abstract

“…22 Zhou et al demonstrated that a robust zirconium-based MOF can serve as a sensor to detect tetracycline (TC) in water. 23 However, norfloxacin (NOR) as a broad-spectrum fluoroquinolone antibacterial agent that can cause nausea, depression, and even worse results, 24,25 the effective and specific detection of NOR by fluorescent CPs is rarely reported. 26 Metal ions and mixed N/O-donor linkers affect the luminescence properties of CPs.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive fluorescence detection of norfloxacin in aqueous medium employing a 2D Zn(ii)-based coordination polymer

Zeng

Cui

2022

CrystEngComm

View full text Add to dashboard Cite

show abstract

“…The existence of a high probability of failure to achieve bacteriological cure with streptomycin, the preference drug to date, has been recognized (Gerritsen, Koopmans, Dekker, De Jong, & Olyhoek, ; Gerritsen, Koopmans, & Olyhoek, ). Other antimicrobial drugs such as amoxicillin (Smith et al., ), oxytetracycline, tilmicosin, and ceftiofur (Alt et al., ) have been tested, in which low efficiencies have been reported and, as indicated above, fluoroquinolones are not particularly effective in the treatment of leptospirosis in veterinary medicine (Griffith et al, ; Mauro & Harkin, ; Wu et al., ). Considering this global scenario, it is tempting to think that it would be useful to carry out both an efficacy study in the face of a controlled challenge of leptospirosis, as well as a clinical study of outbreaks in the field, using Enro‐C.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of enrofloxacinHCl‐2H₂O (ENRO‐C),PK/PD, and Monte Carlo modeling vs. Leptospiraspp. in cows

Mendoza

Gutiérrez

et al. 2019

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

The pharmacokinetics, PK/PD ratios, and Monte Carlo modeling of enrofloxacin HCl‐2H2O (Enro‐C) and its reference preparation (Enro‐R) were determined in cows. Fifty‐four Jersey cows were randomly assigned to six groups receiving a single IM dose of 10, 15, or 20 mg/kg of Enro‐C (Enro‐C10, Enro‐C15, Enro‐C20) or Enro‐R. Serial serum samples were collected and enrofloxacin concentrations quantified. A composite set of minimum inhibitory concentrations (MIC) of Leptospira spp. was utilized to calculate PK/PD ratios: maximum serum concentration/MIC (Cmax/MIC90) and area under the serum vs. time concentration of enrofloxacin/MIC (AUC0‐24/MIC90). Monte Carlo simulations targeted Cmax/MIC = 10 and AUC0‐24/MIC = 125. Mean Cmax obtained were 6.17 and 2.46 μg/ml; 8.75 and 3.54 μg/ml; and 13.89 and 4.25 μg/ml, respectively for Enro‐C and Enro‐R. Cmax/MIC90 ratios were 6.17 and 2.46, 8.75 and 3.54, and 13.89 and 4.25 for Enro‐C and Enro‐R, respectively. Monte Carlo simulations based on Cmax/MIC90 = 10 indicate that only Enro‐C15 and Enro‐C20 may be useful to treat leptospirosis in cows, predicting a success rate ≥95% when MIC50 = 0.5 μg/ml, and ≥80% when MIC90 = 1.0 μg/ml. Although Enro‐C15 and Enro‐C20 may be useful to treat leptospirosis in cattle, clinical trials are necessary to confirm this proposal.

show abstract

Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster

Cited by 13 publications

References 17 publications

Antibiotic susceptibilities of livestock isolates of leptospira

Antibiotic susceptibilities of livestock isolates of leptospira

Ultrasensitive fluorescence detection of norfloxacin in aqueous medium employing a 2D Zn(ii)-based coordination polymer

Pharmacokinetics of enrofloxacinHCl‐2H₂O (ENRO‐C),PK/PD, and Monte Carlo modeling vs. Leptospiraspp. in cows

Contact Info

Product

Resources

About

Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster

Cited by 13 publications

References 17 publications

Antibiotic susceptibilities of livestock isolates of leptospira

Antibiotic susceptibilities of livestock isolates of leptospira

Ultrasensitive fluorescence detection of norfloxacin in aqueous medium employing a 2D Zn(ii)-based coordination polymer

Pharmacokinetics of enrofloxacinHCl‐2H2O (ENRO‐C),PK/PD, and Monte Carlo modeling vs. Leptospiraspp. in cows

Contact Info

Product

Resources

About

Pharmacokinetics of enrofloxacinHCl‐2H₂O (ENRO‐C),PK/PD, and Monte Carlo modeling vs. Leptospiraspp. in cows