Low-dose mifepristone increased angiogenesis in a manner involving AQP1

Zhou, Feng; Qian, Zhida; Huang, Lili

doi:10.1007/s00404-018-4989-9

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Endometrial cancer arises from tissue lining the uterus (the endometrium) and accounts for about 95% of uterine cancers. Protein and RNA for AQPs 1, 2, 3, 5, 7 and 9 are normally expressed in endometrium, in which the AQPs are thought to be involved in fluid exchange and estrogen-mediated regulatory effects [ 200 , 201 , 202 , 203 , 204 , 205 , 206 ]. AQP1 expression in endometrial cancer has been correlated with histologic grade, extent of myometrial invasion and the likelihood of extrauterine metastasis [ 207 ], but the functional role of AQP1 in this tissue remains to be defined.…”

Section: Resultsmentioning

confidence: 99%

Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers

Chow

Bowen

Yool

2020

Cancers

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Aquaporin (AQP) channels enable regulated transport of water and solutes essential for fluid homeostasis, but they are gaining attention as targets for anticancer therapies. Patterns of AQP expression and survival rates for patients were evaluated by systematic review (PubMed and Embase) and transcriptomic analyses of RNAseq data (Human Protein Atlas database). Meta-analyses confirmed predominantly negative associations between AQP protein and RNA expression levels and patient survival times, most notably for AQP1 in lung, breast and prostate cancers; AQP3 in esophageal, liver and breast cancers; and AQP9 in liver cancer. Patterns of AQP expression were clustered for groups of cancers and associated with risk of death. A quantitative transcriptomic analysis of AQP1-10 in human cancer biopsies similarly showed that increased transcript levels of AQPs 1, 3, 5 and 9 were most frequently associated with poor survival. Unexpectedly, increased AQP7 and AQP8 levels were associated with better survival times in glioma, ovarian and endometrial cancers, and increased AQP11 with better survival in colorectal and breast cancers. Although molecular mechanisms of aquaporins in pathology or protection remain to be fully defined, results here support the hypothesis that overexpression of selected classes of AQPs differentially augments cancer progression. Beyond fluid homeostasis, potential roles for AQPs in cancers (suggested from an expanding appreciation of their functions in normal tissues) include cell motility, membrane process extension, transport of signaling molecules, control of proliferation and apoptosis, increased mechanical compliance, and gas exchange. AQP expression also has been linked to differences in sensitivity to chemotherapy treatments, suggesting possible roles as biomarkers for personalized treatments. Development of AQP pharmacological modulators, administered in cancer-specific combinations, might inspire new interventions for controlling malignant carcinomas.

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Section: Resultsmentioning

confidence: 99%

Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers

Chow

Bowen

Yool

2020

Cancers

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“…In addition to the proliferation of endothelial cells stimulated by VEGF, the migration of endothelial cells is also a crucial factor in angiogenesis. AQP1 promotes the migration of endothelial cells, and is involved in angiogenesis of tumor [44][45][46][47] . We examined the expression of AQP1 and VEGF in rectal tissues of radiation proctitis mice by immunohistochemistry and western blot, and found that there was a positive correlation between them.…”

Section: ■ Discussionmentioning

confidence: 99%

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF

Gao

You-song

et al. 2020

Acta Cir. Bras.

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Purpose Changrui enema, a traditional Chinese medicine prescription, is used as a supplementary treatment for acute radiation proctitis (ARP). Herein we explored the inhibition effects of Changrui enema on NF-κB and VEGF in ARP mice. Methods A total of 120 C57BL/6 mice were divided randomly into normal mice group, ARP mice group, western medicine enema group (dexamethasone combined with gentamicin), and Changrui enema group. ARP mice were established by pelvic local irradiation. The expression of IL-1β, NF-κB, VEGF, AQP1, AQP3, p-ERK1/2 and p-JNK was determined by immunohistochemistry or western blot. Results The study firstly found that Changrui enema alleviated ARP mice. The expression of IL-1β, NF-κB, VEGF, AQP1 and p-ERK1/2 was increased in ARP mice, and was reserved by Changrui enema. However, the expression of AQP3 and p-JNK was decreased in ARP mice, and was up-regulated by Changrui enema. Conclusions Changrui enema is an effective treatment with fewer side effects for ARP. The mechanism of Changrui enema may be related to the inhibition of inflammation-induced angiogenesis. Changrui enema inhibits IL-1β and NF-κB expression as well as VEGF expression. Interestingly, AQP1 promotes angiogenesis, while AQP3 inhibits inflammation. Changrui enema probably inhibits AQP1 expression by down-regulating p-ERK1/2, and improves AQP3 expression by up-regulating p-JNK.

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“…To overcome CKD microvascular repair and angiogenesis in renal tubular involves mitigating the damage (17). Moreover, increasing evidence disclosed that AQP1 involves the microvessel formation and cell migration (18,19), thus, AQP1 facilitated endothelial cell angiogenesis that could ameliorate renal dysfunction. Based on the above research background, we hypothesized that SQW treatment may promote angiogenesis in the endothelial cell that can reduce renal injury.…”

Section: 7%mentioning

confidence: 99%

Shen-Qi-Wan Protects the Renal Peritubular Capillary From Adenine-mediated Damage by Upregulating Aquaporin 1

Bao¹,

Zhang²,

Yang³

et al. 2020

Preprint

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Background：Shen-Qi-Wan (SQW), a commonly used prescription against chronic kidney disease (CKD) in Traditional Chinese Medicine (TCM), has a nephroprotective action in adenine-induced kidney injury. However, the mechanism of SQW in renal injury remains unclear.Methods: We evaluated the nephroprotective action of SQW in adenine-induced kidney injury and investigated its mechanism in vitro studies.Results: SQW supplementation could alleviate the pathological makers for CKD, ameliorate dysfunction of Hypothalamic-Pituitary-Adrenal (HPA) axis and renal function loss caused by adenine. Alternatively, SQW administration showed an ameliorating effect from the toxicity and alleviated the injury of capillaries around renal tubules instigated by adenine through increasing AQP1 mRNA and protein level. In vitro experiments, SQW medicated serum enhanced the migration and lumen formation ability of HMEC-1 cells, and significantly increased AQP1 protein level. Moreover, AQP1 knockdown efficiently inhibited migration and lumen formation ability in HMEC-1 cells which could be reversed by SQW medicated serum.Trial registration : This is an animal and cell experiment, trial registration is not necessary.Conclusion: These results suggested that SQW attenuated peritubular capillary injury in adenine induced CKD model rats through boosting angiogenesis in endothelial cell and AQP1 may be a potential target of SQW for treating renal injury.

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Low-dose mifepristone increased angiogenesis in a manner involving AQP1

Cited by 6 publications

References 24 publications

Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers

Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF

Shen-Qi-Wan Protects the Renal Peritubular Capillary From Adenine-mediated Damage by Upregulating Aquaporin 1

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