Low dose methotrexate induced asymptomatic keratinocyte dystrophy in a patient of psoriasis vulgaris

Behera, Biswanath; Kumari, Rashmi; Gochhait, Dnb Debasis; Thappa, Devinder Mohan

doi:10.1111/cup.12810

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Major Psoriasiform Dermatoses1

Approach To the Histopathologic Features Of Psoriasis And It...1

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Cited by 4 publications

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“…Increased dermal fibroblasts may be seen with mild fibrosis 7. Apoptotic keratinocytes have been reported in skin biopsies of psoriasis following methotrexate therapy 14,15…”

Section: Major Psoriasiform Dermatosesmentioning

confidence: 99%

“…7 Apoptotic keratinocytes have been reported in skin biopsies of psoriasis following methotrexate therapy. 14,15 Unfortunately, there is not an immunohistochemical or special stain that reliably distinguishes between psoriasis and other psoriasiform or dermatitic conditions. Careful histopathologic examination along with clinicopathologic correlation are imperative to rendering the appropriate diagnosis.…”

Section: Approach To the Histopathologic Features Of Psoriasis And It...mentioning

confidence: 99%

See 1 more Smart Citation

Updates and Proposed Diagnostic Approach to Psoriasiform Dermatoses

Shakshouk

Erickson

Johnson

et al. 2022

Advances in Anatomic Pathology

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Psoriasiform dermatoses represent a wide array of skin diseases commonly encountered by clinicians and pathologists. While they may present a diagnostic challenge, thorough observation coupled with proper interpretation of subtle additional clinical or histopathologic features provide clues to the correct diagnosis. In this review, we provide updates on emerging entities and develop a systemic approach to establish the pathologic diagnosis, with emphasis on the importance of clinicopathologic correlation.

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“…Increased dermal fibroblasts may be seen with mild fibrosis 7. Apoptotic keratinocytes have been reported in skin biopsies of psoriasis following methotrexate therapy 14,15…”

Section: Major Psoriasiform Dermatosesmentioning

confidence: 99%