Low dose metal particles can induce monocyte/macrophage survival

Lacey, Derek; Kok, Bernard de; Clanchy, Felix I. L.; Bailey, Mark; Speed, Kathy; Haynes, David R.; Graves, Stephen; Hamilton, John A.

doi:10.1002/jor.20914

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…Although this concept is well known in orthopedic related literature, absence of evidence, however, was present in the dental implant related literature. In fact, wear particles can promote monocyte/macrophage survival in vitro possibly via an endogenous mediator (Lacey et al 2011). Literature analysis suggests that titanium particle-induced acute inflammation is due to activation of the NALP3 inflammasome, which leads to increased IL-1b secretion and IL-1-associated signaling, including neutrophil recruitment .…”

Section: Discussionmentioning

confidence: 99%

Microscopical and chemical surface characterization of the gingival portion and connection of an internal hexagon abutment before and after different technical stages of preparation

Canullo¹,

Micarelli²,

Iannello³

2012

Clinical Oral Implants Res

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Section: Discussionmentioning

confidence: 99%

Microscopical and chemical surface characterization of the gingival portion and connection of an internal hexagon abutment before and after different technical stages of preparation

Canullo¹,

Micarelli²,

Iannello³

2012

Clinical Oral Implants Res

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“…This theory is supported by evidence showing that both soluble and particulate debris derived from CoCrMo can induce monocyte–macrophage activation and the secretion of numerous proinflammatory cytokines [28]. Even low doses of CoCrMo promote macrophage survival ( in vitro ), which could contribute to the increased numbers of macrophages in the regions of joint implant failure and the local inflammatory reaction and osteolysis [29].…”

Section: Host Response To Biomaterials and Infectionmentioning

confidence: 97%

Influence of material on the development of device-associated infections

Rochford

Richards

Moriarty

2012

Clinical Microbiology and Infection

103

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The use of implanted devices in modern orthopaedic surgery has greatly improved the quality of life for an increasing number of patients, by facilitating the rapid and effective healing of bone after traumatic fractures, and restoring mobility after joint replacement. However, the presence of an implanted device results in an increased susceptibility to infection for the patient, owing to the creation of an immunologically compromised zone adjacent to the implant. Within this zone, the ability of the host to clear contaminating bacteria may be compromised, and this can lead to biofilm formation on the surface of the biomaterial. Currently, there are only limited data on the mechanisms behind this increased risk of infection and the role of material choice. The impacts of implant material on bacterial adhesion, immune response and infection susceptibility have been investigated individually in numerous preclinical in vitro and in vivo studies. These data provide an indication that material choice does have an impact on infection susceptibility; however, the clinical implications remain to be clearly determined.

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“…It has been shown that metal ions such as vanadium and cobalt chromium decrease monocyte and macrophage survival in a dose-dependent manner [4]. …”

Section: Introductionmentioning

confidence: 99%

The development of whole blood titanium levels after instrumented spinal fusion – Is there a correlation between the number of fused segments and titanium levels?

Ipach¹,

Schäfer²,

Mittag³

et al. 2012

BMC Musculoskelet Disord

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BackgroundMost modern spinal implants contain titanium and remain in the patient’s body permanently. Local and systemic effects such as tissue necrosis, osteolysis and malignant cell transformation caused by implants have been described. Increasing tissue concentration and whole blood levels of ions are necessary before a disease caused by a contaminant develops. The aim of the present study was the measurement of whole blood titanium levels and the evaluation of a possible correlation between these changes and the number of fused segments.MethodsA prospective study was designed to determine changes in whole blood titanium levels after spinal fusion and to analyze the correlation to the number of pedicle screws, cross connectors and interbody devices implanted.Blood samples were taken preoperatively in group I (n = 15), on the first, second and 10th day postoperatively, as well as 3 and 12 months after surgery.Group II (n = 16) served as a control group of volunteers who did not have any metal implants in the body. Blood samples were taken once in this group.The number of screw-rod-connections and the length of the spinal fusion were determined using radiographic pictures. This study was checked and approved by the ethical committee of the University of Tuebingen.ResultsThe mean age in group I was 47 ± 22 years (range 16 - 85 years). There were three male (20%) and twelve female (80%) patients. The median number of fused segments was 5 (range 1 to 11 segments).No statistically significant increase in the titanium level was seen 12 months after surgery (mean difference: -7.2 μg/l, 95% CI: -26.9 to 12.5 μg/l, p = 0.446). By observing the individual titanium levels, 4 out of 15 patients demonstrated an increase in titanium levels 12 months after surgery.No statistically significant correlation between fused segments (r = -0.188, p = 0.503) length of instrumentation (r = -0.329, p = 0.231), number of interbody devices (r = -0.202, p = 0.291) and increase of titanium levels over the observation period was seen.ConclusionsInstrumented spinal fusion does not lead to a statistically significant increase in whole blood titanium levels. There seems to be no correlation between the number of pedicle screws, cross connectors and interbody devices implanted and the increase of serum titanium levels.

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Low dose metal particles can induce monocyte/macrophage survival

Cited by 14 publications

References 33 publications

Microscopical and chemical surface characterization of the gingival portion and connection of an internal hexagon abutment before and after different technical stages of preparation

Microscopical and chemical surface characterization of the gingival portion and connection of an internal hexagon abutment before and after different technical stages of preparation

Influence of material on the development of device-associated infections

The development of whole blood titanium levels after instrumented spinal fusion – Is there a correlation between the number of fused segments and titanium levels?

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