Low dose irradiation permits immunization of A/J mice with subimmunogenic numbers of SaI cells

Anderson, Robert E.; Tokuda, S.; Williams, W. L.; Spellman, Craig W.

doi:10.1038/bjc.1986.204

Cited by 15 publications

(5 citation statements)

References 8 publications

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“…The use of this phenomenon to achieve enhanced tumor control was reported by several investigators (Hellstrom and Hellstrom, 1978;Tilkin et al, 1981;Anderson et al, 1982), although the optimal TBI doses to cause synergistic effects in these studies ranged from 20 cGy to 4 Gy. Anderson et al reported that growth control effects on tumors were observed if the recipient mice were exposed to 5 or 25 cGy of TBI before or just after tumor cell transplantation (Anderson et al, 1986). However, in our study, the effect of TBI was maintained during a 12-h period, before or after tumor-cell transplantation.…”

Section: Discussioncontrasting

confidence: 49%

Radiobiological Basis for Cancer Therapy by Total or Half-Body Irradiation

Sakamoto¹

2004

Nonlinearity in Biology, Toxicology, Medicine

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Section: Discussioncontrasting

confidence: 49%

Radiobiological Basis for Cancer Therapy by Total or Half-Body Irradiation

Sakamoto¹

2004

Nonlinearity in Biology, Toxicology, Medicine

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“…Possible mechanisms include increased expression of cytokine genes such as IL-1␤ [11] and changes of T-lymphocyte subsets by killing the radiation-sensitive T-cell subpopulation [12][13][14][15]. In most of the reports on radiationinduced cytokine expression or changes of T-cell subsets mentioned above, doses more than 2 Gy were used, which were too high to infer the effects of 0.1 to 0.2 Gy irradiation.…”

Section: Introductionmentioning

confidence: 99%

Induction of interleukin‐1β and interleukin‐6 mRNA by low doses of ionizing radiation in macrophages

Hosoi

Miyachi

Matsumoto

et al. 2001

Intl Journal of Cancer

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SUMMARYWe have previously reported the antimetastatic effects and augmentation of immune responses, which would be a mechanism of the antimetastatic effects, of 0.1 to 0.2 Gy total body irradiation. To elucidate the cellular mechanisms of the augmentation of immune response, we investigated the effects of low-dose irradiation on gene expression of interleukin-1␤ (IL-1␤) and IL-6 using mouse peritoneal macrophages in vitro. Absolute mRNA quantification was carried out using competitive polymerase chain reaction. Gene expression of IL-1␤ and IL-6 was increased 1 to 2 hr after 2.0 Gy irradiation and then decreased to below the basal expression level 4 hr after irradiation. Irradiation with 0.1 Gy increased IL-6 expression 2 hr after irradiation, but it did not affect IL-1␤ expression. Downregulation of IL-1␤ and IL-6 observed 4 hr after 2.0 Gy irradiation was not observed with 0.1 Gy irradiation. The protein kinase C (PKC) inhibitor H7 and the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor wortmannin inhibited induction of IL-1␤ and IL-6 expression, which suggests that radiation-induced IL-1␤ and IL-6 expression is achieved by PKC-and PI3-kinase-mediated signaling.

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“…Poor self-care behaviors and lack of adherence to diet and therapeutic regimen increase rehospitalization of patients with HF by 20-60 percent [17]. Self-care is one of the most important aspects of treatment [2], and is the pillar of managing HF, which includes adhering to low salt diet, medical regimen and so on to maintain body's physiologic stability and health [18]. A sudden weight gain, daily weighing, adhering to food and drug regimen, regular physical activity, abstinence from smoking, contacting the physician in case of edema on foot, ankle, shin, or stomach, measuring daily amount of urine, and not drinking a lot of liquids are examples of self-care behaviors [2].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Educating Self-Care Behaviors to Patients With Heart Failure in Hospitals of Zahedan

et al. 2013

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Background: Heart failure is a chronic disease in the elderly. Self-care education has a significant role in preventing the disease, its progress, and complications. Objectives: The present study aimed to assess the effect of training on self-care behaviors among patients with heart failure in hospitals of Zahedan City in 2012. Materials and Methods:The present study had a quasi-experimental interventional design with control group, and was conducted in CCU and post-CCU wards in hospitals affiliated to Zahedan University of Medical Sciences in 2012. There were 140 hospitalized patients in two equal groups of case (70 people) and control (70 people). The case group received an educational package including a pamphlet, an educational CD, and educational footage for their cell phone. After one month, they took the posttest. The data were analyzed by SPSS statistical software ver. 18. Results: After training, the mean scores of awareness, attitude and practice among patients in the case group were respectively 8.93 ± 2.32, 47.69 ± 2.21, and 66.04 ± 3.44 (P < 0.0001). The mean score difference of attitude in the intervention group was 17.78 ± 7.0, and 3.30 ± 6.85 in the control. The mean score difference of practice in the intervention group was 26.57 ± 6.37, and 2.08 ± 7.16in the control group (P < 0.0001). Conclusion:The results of the present study showed that self-care behaviors in patients with heart failure were influenced by awareness, and their practice improved with increasing their knowledge. Therefore, it is recommended to give an educational pamphlet video to patients with heart failure.

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Low dose irradiation permits immunization of A/J mice with subimmunogenic numbers of SaI cells

Cited by 15 publications

References 8 publications

Radiobiological Basis for Cancer Therapy by Total or Half-Body Irradiation

Radiobiological Basis for Cancer Therapy by Total or Half-Body Irradiation

Induction of interleukin‐1β and interleukin‐6 mRNA by low doses of ionizing radiation in macrophages

The Effect of Educating Self-Care Behaviors to Patients With Heart Failure in Hospitals of Zahedan

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