Low-dose ionising radiation effects: effects of thoron inhalation

Menon, Aditya; Indu, Rania; Chacko, Tiju; Nair, Cherupally Krishnan Krishnan

doi:10.1504/ijlr.2014.063409

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…However, after detecting high-thoron background regions, researchers have focused on the effects of inhaled thoron (Ramola et al 2012). Menon et al (2014) examined changes in antioxidative functions including expression of SOD and reduced glutathione (GSH) in mouse organs by thoron inhalation at a high concentration of approximately 500 kBq/m 3 within 30 days of inhalation. The results showed a significant increase in DNA damage of lung tissue, and significant decrease in some antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Comparison of antioxidative effects between radon and thoron inhalation in mouse organs

Kobashi

Kataoka

Kanzaki

et al. 2020

Radiat Environ Biophys

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Comparison of antioxidative effects between radon and thoron inhalation in mouse organsBackground: Radon therapy has been traditionally performed globally for oxidative stressrelated diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. Objective: In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Methods:Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m 3 or 2000 Bq/m 3 , and thoron inhalation at a dose of 500 Bq/m 3 or 2000 Bq/m 3 were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. Results: The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Conclusion:Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron.

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Section: Introductionmentioning

confidence: 99%

Comparison of antioxidative effects between radon and thoron inhalation in mouse organs

Kobashi

Kataoka

Kanzaki

et al. 2020

Radiat Environ Biophys

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show abstract

“…This suggests that thoron inhalation at 2000 Bq/m 3 results in a redox imbalance in the liver. A high thoron concentration of approximately 530 kBq/m 3 decreased the activity of GSH peroxidase, an antioxidant enzyme, within 30 days of exposure, in the lung and heart and increased LPO levels [ 16 ]. We also reported that the combination of radon inhalation (2000 Bq/m 3 ) for 24 h and AA administration after radon inhalation effectively inhibited acute alcohol-induced liver damage [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice

Kataoka

Ishida

Naoe

et al. 2022

Journal of Radiation Research

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Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m3 and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m3 thoron inhalation was lower than that after 500 Bq/m3 thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m3 and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m3 was more effective than that at 2000 Bq/m3, possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m3 and AA administration promoted an early recovery from alcohol-induced liver damage.

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Assessment of Threshold Dose of Thoron Inhalation and Its Biological Effects by Mimicking the Radiation Doses in Monazite Placer Deposits Corresponding to the Normal, Medium and Very High Natural Background Radiation Areas

Chaudhury

Sen

Biswas

et al. 2022

Biol Trace Elem Res

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Low-dose ionising radiation effects: effects of thoron inhalation

Cited by 5 publications

References 22 publications

Comparison of antioxidative effects between radon and thoron inhalation in mouse organs

Comparison of antioxidative effects between radon and thoron inhalation in mouse organs

Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice

Assessment of Threshold Dose of Thoron Inhalation and Its Biological Effects by Mimicking the Radiation Doses in Monazite Placer Deposits Corresponding to the Normal, Medium and Very High Natural Background Radiation Areas

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