Low dose interpolated average CT for thoracic PET/CT attenuation correction using an active breathing controller

Abstract

IACT-ABC reduces respiratory artifacts, PET/CT misregistration and enhances lesion quantitation. This technique is a robust and low dose AC protocol for clinical oncology application especially in the thoracic region.

Interpolated average CT for cardiac PET/CT attenuation correction

“…The robustness of the ABC device was discussed in our previous work. 21 Our recruited patients all showed good compliance to the device, with minimal increase of the radiation dose as the lowest tube current, i.e., 10 mA, was used in the study. The results of IACT substantially approached to those of the ACT as compared to HCT ( Figures 4 and 6), indicating the effectiveness of our algorithm and the ABC.…”

“…?-based acquisition program to ensure the patients could hold their breaths at the desired end-inspiration and end-expiration phases, with breathing amplitude similar to the free breathing state. 21,27 The IACT was then generated using the same procedure as mentioned in the simulation with the captured extreme CT phases. All data were reconstructed on the scanner workstation using 3D OS-EM method with 2 iterations and 28 subsets.…”

“…Its effectiveness in image quality and quantitative accuracy improvement for thoracic lesions were demonstrated in our previous simulation 20 and clinical studies. 21,22 In this study, we aim to evaluate the potential of using IACT for PET AC in cardiology applications. Both simulation and patient data were analyzed to compare the performance of IACT, ACT, and HCT.…”

Respiratory Motion Reduction in PET/CT Using Abdominal Compression for Lung Cancer Patients

“…This movement typically causes a larger tumor volume size to appear in PET images, compared with the actual size of the tumor, leading to PET/CT misalignment [14]. The motion is even more complex when the lesions are attached to the rigid structure of the thorax, (eg, the pleura near the ribcage (Patients 3 and 10) and the diaphragm (Patient 5)).…”

“…Recently, the interpolated average CT used for PET/CT AC corrected the PET/CT misregistration and enhanced lesion quantitation accompanied by radiation deduction. However, the complicated postimaging process is still a concern regarding the use of these techniques in clinical practice [12]–[14].…”