A multicentre trial was designed to determine the dose-response and side-effects of esmolol when administered as a single iv bolus prior to induction of anaesthesia for controlling the haemodynamic response to tracheal intubation. Five hundred and forty-eight patients from 12 university-affiliated centres across Canada were randomized prospectively to receive either placebo (PLAC) or esmolol (E) in a dose of 100 mg (EIO0) or 200 mg (E200
however, a decrease in SBP occurred in all three groups following induction of anaesthesia (P < 0.003), with the largest decrease (17 +-4%) occurring in patients who had received E 200. The overall incidence of hypotension (SBP < 90 mmHg) was greater in the E200 group (33%) than either the EIO0 (25%) or PLAC (16%) groups (P < 0.05). Other