Low dose CT screening for lung cancer

Baldwin, David R; Haaf, Kevin ten; Rawlinson, Janette; Callister, Matthew

doi:10.1136/bmj.j5742

Cited by 11 publications

(11 citation statements)

References 11 publications

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“…[1][2][3] Based largely on the results of NLST the US Preventive Services Task Force (USPSTF) recommended screening with LDCT in 2013. [4] This has been followed by similar statements from other countries including the Chief Executive of the NHS in the UK, Simon Stevens, in 2017 [5] and the recent European position statement. [6] H " " differs from the views currently held by the UK National Screening Committee (NSC) most recent review in 2006 concluded such screening was not recommended.…”

Section: Accepted Manuscript Introductionmentioning

confidence: 85%

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The cost-effectiveness of the Manchester ‘lung health checks’, a community-based lung cancer low-dose CT screening pilot

et al. 2018

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Background Previous evaluations of low-dose CT (LDCT) lung cancer screening programmes have taken very different approaches in the design of the informative trials and the methods applied to determine cost-effectiveness. Therefore, it has not been possible to determine if differences in costeffectiveness are due to different screening approaches or the evaluation methodology. This study reports the findings of an evaluation of the first round of a community-based, LDCT screening pilot Manchester, applying previously published methodology to ensure consistency.

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Section: Accepted Manuscript Introductionmentioning

confidence: 85%

“…The intrinsic appeal of such screening programmes is clear, with lung cancer causing around 35,600 deaths every year in the UK [8], a level that has stayed stubbornly high. Despite knowledge of the risk factors the majority of patients still present with advanced disease [5] when curative treatment options are limited.…”

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

The cost-effectiveness of the Manchester ‘lung health checks’, a community-based lung cancer low-dose CT screening pilot

et al. 2018

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“…However, screening entails harms in the form of false-positive screening test referrals and follow-up diagnostics. The efficiency of cancer screening using CT depends in part on optimized criteria for reporting and managing lung nodules; therefore, radiologic and oncologic expert societies have developed guidelines [6][7][8][9][10] for using nodule characteristics as predictors of malignancy and as decision-making indicators to guide further diagnostic work.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Prediction Models for Identifying Malignancy in Pulmonary Nodules Detected via Low-Dose Computed Tomography

et al. 2020

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IMPORTANCE Malignancy prediction models based on participant-related characteristics and imaging parameters from low-dose computed tomography (CT) may improve decision-making regarding nodule management and diagnosis in lung cancer screening. OBJECTIVE To externally validate 5 malignancy prediction models that were developed in screening settings, compared with 3 models that were developed in clinical settings, in terms of discrimination and absolute risk calibration among participants in the German Lung Cancer Screening Intervention trial. DESIGN, SETTING, AND PARTICIPANTS In this population-based diagnostic study, malignancy probabilities were estimated by applying 8 prediction models to data from 1159 participants in the intervention arm of the Lung Cancer Screening Intervention trial, a randomized clinical trial conducted from October 23, 2007, to April 30, 2016, with ongoing follow-up. This analysis considers end points up to 1 year after individuals' last screening visit. Inclusion criteria for participants were at least 1 noncalcified pulmonary nodule detected on any of 5 annual screening visits, receiving a lung cancer diagnosis within the active screening phase of the Lung Cancer Screening Intervention trial, and an unequivocal identification of the malignant nodules. Data analysis was performed from

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“…2 In this context, supporting the implementation of new initiatives and evidence-based guidelines is a challenge. The recent expansion of screening for lung cancer is potentially one of the most important ways to reduce lung cancer mortality, 3 but it has to be done correctly to ensure maximum benefit and cost-effectiveness. 4 NHS England has published a protocol recommending the use of guidelines in the management of pulmonary nodules 5 and in the USA there is a detailed implementation guide.…”

Section: Introductionmentioning

confidence: 99%

Reporting radiographers and their role in thoracic CT service improvement: managing the pulmonary nodule

et al. 2020

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Objectives: The use of cross-sectional imaging in clinical medicine has been a major step forward in the management of many conditions but with that comes the increasing demand on resources and the detection of other potentially significant findings. This, in the context of a shortage of skilled radiologists, means that new ways of working are important. In thoracic CT, pulmonary nodules are a significant challenge because they are so common. Poor and inconsistent management can both cause harm to patients and waste resources so it is important that the latest guidelines are followed. The latter mandate the use of semi-automated volumetry that allows more precise management but is time-consuming. Methods: Reporting radiographers were iteratively trained in the use of semi-automated volumetry for pulmonary nodules by experienced thoracic radiologists. Once trained in this specific aspect, radiographers completed reporting of pulmonary nodules, checked by radiologists. Results: Radiographer reporting reduced radiologist time in reporting nodules and measuring their volume. Most of the volumetry was completed prior to the multidisciplinary meeting. This facilitated an increase in the number of patients discussed in 60 min from 15 to 22. Radiographers failed to detect few nodules, although a second read by radiologists is required in any case for other aspects of the reporting. Conclusion: Reporting radiographers, working with radiologists in a supportive setting, can deliver the radiology in a lung nodule pathway, reducing the time commitment from radiologists and the pulmonary nodule multidisciplinary team members, whilst using this as an opportunity to conduct research.

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Low dose CT screening for lung cancer

Abstract: Pilots in car parks take the UK one step closer to national screening

Cited by 11 publications

References 11 publications

The cost-effectiveness of the Manchester ‘lung health checks’, a community-based lung cancer low-dose CT screening pilot

The cost-effectiveness of the Manchester ‘lung health checks’, a community-based lung cancer low-dose CT screening pilot

Evaluation of Prediction Models for Identifying Malignancy in Pulmonary Nodules Detected via Low-Dose Computed Tomography

Reporting radiographers and their role in thoracic CT service improvement: managing the pulmonary nodule

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