Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model

Lamberto, Federica; Shashikadze, Bachuki; Elkhateib, Radwa; Lombardo, Salvo Danilo; Horánszky, Alex; Balogh, Andrea; Kistamás, Kornél; Zana, Melinda; Menche, Jörg; Fröhlich, Thomas; Dinnyés, András

doi:10.1016/j.envpol.2023.122359

Cited by 4 publications

(1 citation statement)

References 119 publications

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“…As reviewed elsewhere, the ECM can alter MS disease outcomes, and, conversely, the neuroinflammation in MS alters the composition of the ECM [27]. There are many crucial elements still unknown in MS pathogenesis that can alter ECM composition, such as the role of environmental exposures [28]. Finally, this study did not investigate the consequence of SPARC upregulation in MS.…”

Section: Discussionmentioning

confidence: 92%

Uncovering Novel Extracellular Matrix Transcriptome Alterations in Lesions of Multiple Sclerosis

Stephenson,

Jain,

Ghorbani

et al. 2024

IJMS

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The extracellular matrix (ECM) of the central nervous system (CNS) is an interconnected network of proteins and sugars with critical roles in both homeostasis and disease. In neurological diseases, excessive ECM deposition and remodeling impact both injury and repair. CNS lesions of multiple sclerosis (MS), a chronic inflammatory and degenerative disease, cause prominent alterations of the ECM. However, there are a lack of data investigating how the multitude of ECM members change in relation to each other and how this affects the MS disease course. Here, we evaluated ECM changes in MS lesions compared to a control brain using databases generated in-house through spatial mRNA-sequencing and through a public resource of single-nucleus RNA sequencing previously published by Absinta and colleagues. These results underline the importance of publicly available datasets to find new targets of interest, such as the ECM. Both spatial and public datasets demonstrated widespread changes in ECM molecules and their interacting proteins, including alterations to proteoglycans and glycoproteins within MS lesions. Some of the altered ECM members have been described in MS, but other highly upregulated members, including the SPARC family of proteins, have not previously been highlighted. SPARC family members are upregulated in other conditions by reactive astrocytes and may influence immune cell activation and MS disease course. The profound changes to the ECM in MS lesions deserve more scrutiny as they impact neuroinflammation, injury, and repair.

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Section: Discussionmentioning

confidence: 92%

Uncovering Novel Extracellular Matrix Transcriptome Alterations in Lesions of Multiple Sclerosis

Stephenson,

Jain,

Ghorbani

et al. 2024

IJMS

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Influence of Exposure to Bisphenols on Cardiac Structure/Function

Chevrier,

Chalifour

2024

Reference Module in Biomedical Sciences

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Use of cardiac cell cultures from salmonids to measure the cardiotoxic effect of environmental pollutants

Krebs,

Bauer,

Graff

et al. 2024

Journal of Fish Diseases

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Environmental stressors such as micro‐ and nanosized plastic particles (MNPs) or crude oil have a detrimental effect on aquatic animals; however, the impact upon the cardiovascular system of fish remains relatively under‐researched. This study presents a novel approach for investigating the effect of crude oil and MNPs on the cardiac system of fish. We used salmonid larvae and cardiac cell cultures derived from hearts of salmonid fish and exposed them to environmental stressors. Following exposure to plastic particles or crude oil, the larvae exhibited some variation in contraction rate. In contrast, significant alterations in the contraction rate were observed in all cardiac cell cultures. The greatest differences between the control and treatment groups were observed in cardiac cell cultures derived from older brown trout. Following 7 days of exposure to MNPs or crude oil in Atlantic salmon larval hearts or cardiac cell cultures, there were only minor responses noted in mRNA expression of the selected marker genes. These findings show the use of a novel in vitro technique contributing to the existing body of knowledge on the impact of MNPs and crude oil on the cardiovascular system of salmonids and the associated risk.

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Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model

Cited by 4 publications

References 119 publications

Uncovering Novel Extracellular Matrix Transcriptome Alterations in Lesions of Multiple Sclerosis

Uncovering Novel Extracellular Matrix Transcriptome Alterations in Lesions of Multiple Sclerosis

Influence of Exposure to Bisphenols on Cardiac Structure/Function

Use of cardiac cell cultures from salmonids to measure the cardiotoxic effect of environmental pollutants

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