Low-Dose Baclofen-Induced Encephalopathy in a Healthy Young Adult: Is Baclofen Toxicity Dose-Dependent?

Abstract

Baclofen is a commonly used medication for managing muscle spasticity with the potential of causing lifethreatening adverse effects, including encephalopathy as well as withdrawal symptoms including confusion and hallucinations following abrupt discontinuation. Severe toxicity with baclofen is common in patients with kidney disease, hence the importance of dose reduction and monitoring in patients with renal impairment. This article reports a case of encephalopathy with low-dose baclofen in an otherwise healthy young adult concurrently taking ibuprofen and baclofen and aims to underscore the importance of potential drug interaction and patient education when initiating baclofen.

An Uncommon Side Effect of Baclofen Withdrawal in End Stage Renal Disease

“…This is oftentimes prevented through intravenous fluids. Since baclofen is mainly excreted through the kidneys without being altered, baclofen withdrawal is more commonly seen in patients with end stage renal disease (ESRD) [ 5 ]. Per literature review, patients with ESRD have a 68% chance of developing baclofen toxicity and thus baclofen withdrawal [ 6 ].…”