Low-Dose Aspirin in the Prevention of Hypertensive Disorders of Pregnancy in Relatively Low-Risk Nulliparous Women

Davies, N; Gazvani, M. R.; Farquharson, Roy G.; Walkinshaw, Stephen

doi:10.3109/10641959509058050

Cited by 25 publications

(22 citation statements)

References 12 publications

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“…Placental abruption was reported as an outcome in 12 studies, in which LDA was started after 16 weeks. There was a trend towards a marginally increased risk of placental abruption (RR, 1.20; 95% CI, 1.00–1.46; P = 0.06) in women taking LDA, though it failed to reach statistical significance (Figure 2b).…”

Section: Resultsmentioning

confidence: 98%

“…Following review of the abstracts, 119 potentially suitable trials were selected for full review. Of these, 40 studies involving 34 807 participants, met the inclusion criteria and were included in the final analysis (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…None of the included studies reported on intrapartum fetal distress as an outcome. Due to the limited number of studies reporting the outcomes of operative vaginal birth, emergency CS for intrapartum fetal distress and birth asphyxia, these outcomes were not included in the meta‐analysis, and the individual study findings from the 10 studies reporting on these outcomes are presented in Table S1. Three studies reported on operative‐vaginal‐delivery rate, with all showing a reduced, albeit non‐significant, risk among women taking LDA.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies reported on operative‐vaginal‐delivery rate, with all showing a reduced, albeit non‐significant, risk among women taking LDA. Four studies reported as an outcome, emergency CS for intrapartum fetal distress, of which three showed a non‐significant increase in risk, and one demonstrated a non‐significant risk reduction in women taking LDA. Birth asphyxia/acidosis was reported in five studies, however, in one study it was defined as either cord artery pH < 7.15 or base excess < −7 mmol/L or 5‐min Apgar score < 6, in another as base excess > 90 th centile (12 mEq/L) and in a third as cord pH < 7.15, while it was not defined in the other two studies.…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies reported NICU admission as an outcome. Regardless of the dose administered, LDA had no impact on this outcome (RR, 0.95; 95% CI, 0.90–1.01; P = 0.08).…”

Section: Resultsmentioning

confidence: 99%

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Impact of low‐dose aspirin on adverse perinatal outcome: meta‐analysis and meta‐regression

Turner

Robertson

Härtel

2020

Ultrasound in Obstet & Gyne

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CONTRIBUTIONWhat are the novel findings of this work? Aspirin intake, when commenced at ≤ 16 weeks' gestation at a dose ≥ 100 mg, results in a reduction in the risk of perinatal death, independently of its concomitant beneficial effect on reducing the risk of pre-eclampsia and preterm birth. What are the clinical implications of this work?Given that low-dose aspirin is a simple, cheap and effective intervention and is relatively well tolerated by women, our results suggest that it may be reasonable to consider its use in a wider, more general context, prior to 16 weeks' gestation, to improve perinatal outcome. ABSTRACTObjective To perform a meta-analysis and metaregression of randomized controlled trials (RCTs) to evaluate the impact of low-dose aspirin (LDA) on perinatal outcome, independent of its effect on pre-eclampsia (PE), preterm birth and low birth weight.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies reported NICU admission as an outcome. Regardless of the dose administered, LDA had no impact on this outcome (RR, 0.95; 95% CI, 0.90–1.01; P = 0.08).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Impact of low‐dose aspirin on adverse perinatal outcome: meta‐analysis and meta‐regression

Turner

Robertson

Härtel

2020

Ultrasound in Obstet & Gyne

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Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality

Henderson

Vesco

Senger

et al. 2021

JAMA

121

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IMPORTANCE Preeclampsia is a hypertensive disorder of pregnancy that poses serious maternal and infant health risks. Previous systematic reviews have established benefits of low-dose aspirin taken during pregnancy to prevent preeclampsia and its sequelae.OBJECTIVE To update evidence for the US Preventive Services Task Force (USPSTF) on effectiveness of aspirin use in preventing preeclampsia in individuals at increased risk based on clinical risk factors or measurements associated with higher disease incidence than in the general population.

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