Low‐dose aspirin improves blood perfusion of endometrium of unexplained recurrent biochemical pregnancy loss

Abstract

Due to the advent of high-sensitivity pregnancy tests, biochemical pregnancy losses (BPLs) have been found to be much more common than previously thought, involving as many as 50%-60% of all pregnancies. 1 This is because most women who experience a BPL never even realize they are pregnant unless they are trying to conceive and are testing regularly and early. Unlike clinical early miscarriage, in which karyotypically abnormal embryos are the cause of 50% of losses, 2 the exact causes of BPL remain unknown. It is thought that BPL might be related to maternal age, reproductive malformation, autoimmune disease, inherited thrombophilia, and endocrine abnormality. 3,4 Herein recurrent biochemical pregnancy loss (RBPL) is defined as two or more BPLs that affect 2%-5% fertile women. 4 Moreover, RBPLs remain unexplained after an extensive assessment are known as unexplained RBPLs (URBPLs). 5 Studies demonstrated that appropriate endometrial receptivity is key to achieving a normal pregnancy. 6 Impaired blood perfusion of

Pterostilbene alleviates abdominal aortic aneurysm via inhibiting macrophage pyroptosis by activating the miR-146a-5p/TRAF6 axis

“…Interestingly, PTE (10 mg kg −1 )-treated mice were the most effective in suppressing the development of experiment AAAs, which was consistent with the dose of aspirin used in the clinic. In previous studies, 58–60 a high dose of aspirin had a poorer effect than a low dose of aspirin, which may increase the risk of bleeding. In addition, when the concentration of PTE increases, some toxic side effects may occur in mice.…”

Male Hyperuricemia Is Associated with Poor Reproductive Outcomes of IVF-ET

“…Some studies also reveal that BPL is linked to female age, embryonic development stage, or abnormal chromosome structure. However, more and more studies describe that BPL is not related to female age [20,21], endometrial abnormality [22,23], or chromosome structure abnormality [21,23]; instead, poor embryo quality dose increases BPLR [24]. Few studies have reported the increase in BPL caused by male factors.…”

Specific plasma microRNA profiles could be potential non-invasive biomarkers for biochemical pregnancy loss following embryo transfer

“…Late miscarriage occurs after 12 gestational weeks. Unlike early miscarriage, most studies conclude that the leading causes of BPL are endometrial factors rather than embryonic factors [ 1 – 6 ]. On the contrary, more than 50% causes of early miscarriage are abnormal embryo karyotypes.…”