Low-dose ASA Response Using the PFA-100 in Women With High-risk Pregnancy

Soluble B7‐H4 blood serum levels are elevated in women at high risk for preeclampsia in the first trimester, as well as in patients with confirmed preeclampsia

“…12 In this study, we included a cohort of patients who were identified as at >1:100 risk of developing PE before 34 weeks of pregnancy. This is not surprising because approximately 30% of pregnant women are resistant to aspirin therapy, and the prevalence of non-responsiveness increase with the week of pregnancy, as shown by Caron et al 34 Our results are comparable to the results of the ASPRE-trial, in which PE was not prevented by aspirin in 18% of high-risk patients. 33 In our study, 25% of women at high risk of PE developed PE later in the pregnancy, despite taking aspirin.…”

Prevention of Preeclampsia and Intrauterine Growth Restriction With Aspirin Started in Early Pregnancy

“…Issues that should be considered in future randomized trials should include the optimal dose of aspirin or platelet aggregation tests for dosage adjustments. 75,76 Moreover, with the recent publication of a randomized controlled trial showing that low-molecular weight heparin can also decrease the recurrence of severe preeclampsia, future studies should compare low-dose aspirin to heparin in highrisk populations. 77 Based on the results of this review, current evidence indicates that low-dose aspirin started in early pregnancy may reduce the incidence of preeclampsia, IUGR and preterm birth in women identified at moderate or high risk for preeclampsia.…”

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

“…Aspirin is more effective in decreasing preeclampsia: (i) among high risk women (NNT 19, 95% CI 13-34), (ii) when initiated before 16 weeks [252][253][254][255], (iii) at doses >80 mg/day [249,[256][257][258][259]; and (iv) when taken at bedtime [260,261]. Adjusting dosage based on platelet function testing may improve aspirin effectiveness [262].…”