Low-dose Almitrine Bismesylate in the Treatment of Hypoxemia due to Chronic Obstructive Pulmonary Disease

Winkelmann, Bernhard R.; Kullmer, T.; Kneissl, Dieter G.; Trenk, Dietmar; Kronenberger, H

doi:10.1378/chest.105.5.1383

Cited by 22 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Almitrine increased P a O 2 , usually in association with increased P PA and unaltered Q (266, 1260,1683,1684,1792,2108), and improved V A /Q homogeneity, as indicated by both MIGET analysis (266, 1260) and 81m Kr gamma scintigraphy (1792). These results suggest that enhancement of HPV in low V A /Q regions increased diversion of blood flow to normal V A /Q regions, leading to improved V A /Q matching.…”

Section: Vi) Chronic Obstructive Pulmonary Diseasementioning

confidence: 80%

Hypoxic Pulmonary Vasoconstriction

Sylvester

Shimoda

Aaronson

et al. 2012

Physiological Reviews

603

621

View full text Add to dashboard Cite

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last 20 years, it has been clear that the essential sensor, transduction, and effector mechanisms responsible for hypoxic pulmonary vasoconstriction (HPV) reside in the pulmonary arterial smooth muscle cell. The main focus of this review is the cellular and molecular work performed to clarify these intrinsic mechanisms and to determine how they are facilitated and inhibited by the extrinsic influences of other cells. Because the interaction of intrinsic and extrinsic mechanisms is likely to shape expression of HPV in vivo, we relate results obtained in cells to HPV in more intact preparations, such as intact and isolated lungs and isolated pulmonary vessels. Finally, we evaluate evidence regarding the contribution of HPV to the physiological and pathophysiological processes involved in the transition from fetal to neonatal life, pulmonary gas exchange, high-altitude pulmonary edema, and pulmonary hypertension. Although understanding of HPV has advanced significantly, major areas of ignorance and uncertainty await resolution.

show abstract

Section: Vi) Chronic Obstructive Pulmonary Diseasementioning

confidence: 80%

Hypoxic Pulmonary Vasoconstriction

Sylvester

Shimoda

Aaronson

et al. 2012

Physiological Reviews

603

621

View full text Add to dashboard Cite

show abstract

“…Almitrine has recently been shown to have oxygen free radical-scavenging ability (6,7). It also increases calcium release from the sarcoplasmic reticulum and is used in the treatment of respiratory failure (32). At present, however, the basic mechanisms of action of almitrine are unknown.…”

mentioning

confidence: 99%

Almitrine and doxapram decrease fatigue and increase subsequent recovery in isolated rat diaphragm

McGuire

Carey

O’Connor

1997

Journal of Applied Physiology

View full text Add to dashboard Cite

The effects of almitrine bimesylate and doxapram HCl on isometric force produced by in vitro rat diaphragm were studied during direct muscle activation at 37 degrees C. Doxapram and almitrine ameliorate respiratory failure clinically by indirectly increasing phrenic nerve activity. This study was carried out to investigate possible direct actions of these agents on the diaphragm before and after fatigue of the fibers. Two age groups of animals were chosen [6-14 wk (group 1) and 50-55 wk (group 2)] because it is known that increasing age decreases a muscle fiber's resistance to fatigue. Muscle strips were isolated from both group 1 and group 2 and directly stimulated (2-ms pulse duration, 5-15 V) to produce twitch tensions of 1.3 and 2.1 N/cm2, respectively. At low concentrations, doxapram (

show abstract

“…35 No clinical signs of peripheral neuropathy were observed in any patient at the time of hospital discharge. Polyneuropathy is a side-effect related to almitrine, but it has been observed in patients receiving high doses over periods of several months [36][37][38] and the effects are reversed after stopping the treatment. 39 The hospital stay and intrahospital mortality of the patients was similar in all groups.…”

Section: Discussionmentioning

confidence: 99%