Low dopamine D5 receptor density in hippocampus in an animal model of attention-deficit/hyperactivity disorder (ADHD)

Medin, Tirill; Rinholm, Johanne Egge; Owe, Simen Gylterud; Sagvolden, Terje; Gjedde, Albert; Storm‐Mathisen, Jon; Bergersen, Linda Hildegard

doi:10.1016/j.neuroscience.2013.03.036

Cited by 17 publications

(11 citation statements)

References 94 publications

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“…Several studies have shown that MPH can modulate hippocampal physiology and/or functions, including long-term potentiation, learning, and memory (Bethancourt, Camarena, & Britton, 2009; Dommett, Henderson, Westwell, & Greenfield, 2008). Likewise, Verster and colleagues (2010) found that MPH significantly improves declarative memory functioning of adults with ADHD and speculated that MPH enhances the release of dopamine within the ventrolateral prefrontal cortex and the hippocampal formation that is involved in encoding and retrieval (Medin et al, 2013). In contrast to this, Lagace, Yee, Bolanos, and Eisch (2006) reported that juvenile MPH exposure leads to decreased long-term survival of new neurons in the adult hippocampus of rats.…”

Section: Discussionmentioning

confidence: 99%

Regional Gray Matter Volume Differences Between Adolescents With ADHD and Typically Developing Controls: Further Evidence for Anterior Cingulate Involvement

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Regional Gray Matter Volume Differences Between Adolescents With ADHD and Typically Developing Controls: Further Evidence for Anterior Cingulate Involvement

et al. 2016

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“…Moreover, since the limbic system is grossly involved in emotional arousal and emotion related memory formation, altered signaling through DRD5 may perturb this function, leading to comorbid mood disorder in subjects with ADHD. Deficiency in D5 receptors was hypothesized to contribute to learning problems in an animal model of ADHD, 31 indicating a potential role of DRD5 dysfunction in ADHD associated learning difficulties.…”

Section: Discussionmentioning

confidence: 99%

The Dopamine Receptor D5 May Influence Age of Onset

et al. 2016

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The objective was to investigate contribution of the dopamine receptor 5 (DRD5) gene variants in the symptoms of attention-deficit/hyperactivity disorder (ADHD) probands since brain regions identified to be affected in these group of patients have higher expression of the DRD5 receptor. Out of 22 exonic variants, 19 were monomorphic in the Indo-Caucasoid individuals. rs6283 "C" and rs113828117 "A" exhibited significant higher occurrence in families with ADHD probands. Several haplotypes showed biased occurrence in the probands. Early and late onset groups exhibited significantly different genotypic frequencies. A new G>A substitution was observed in the control samples only. The late onset group exhibited higher scores for hyperactivity as compared to the early onset group. The authors infer that the age of onset of ADHD may at least partially be affected by DRD5 variants warranting further investigation on the role of DRD5 in the disease etiology.

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“…A novel finding in this study was the identification of an increased tendency of Bi of the HIP.L in the ADHD group compared with the ASD and TD groups. Studies from animal models of ADHD have suggested abnormalities in neuronal signaling systems within the hippocampus (Medin et al, 2013;Sterley et al, 2013). A multimodal MRI study in children with ADHD showed that hippocampal volumes were reduced in children with ADHD and that hippocampal-orbitofrontal cortex connectivity was also reduced in children with ADHD (Posner et al, 2014).…”

Section: Pocgl Primarymentioning

confidence: 99%

Shared and Distinct Topologically Structural Connectivity Patterns in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

Wang

et al. 2021

Front. Neurosci.

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BackgroundPrevious neuroimaging studies have described shared and distinct neurobiological mechanisms between autism spectrum disorders (ASDs) and attention-deficit/hyperactivity disorder (ADHD). However, little is known about the similarities and differences in topologically structural connectivity patterns between the two disorders.MethodsDiffusion tensor imaging (DTI) and deterministic tractography were used to construct the brain white matter (WM) structural networks of children and adolescents (age range, 6–16 years); 31 had ASD, 34 had ADHD, and 30 were age- and sex-matched typically developing (TD) individuals. Then, graph theoretical analysis was performed to investigate the alterations in the global and node-based properties of the WM structural networks in these groups. Next, measures of ASD traits [Social Responsiveness Scale (SRS)] and ADHD traits (Swanson, Nolan, and Pelham, version IV scale, SNAP-IV) were correlated with the alterations to determine the functional significance of such changes.ResultsFirst, there were no significant differences in the global network properties among the three groups; moreover, compared with that of the TD group, nodal degree (Ki) of the right amygdala (AMYG.R) and right parahippocampal gyrus (PHG.R) were found in both the ASD and ADHD groups. Also, the ASD and ADHD groups shared four additional hubs, including the left middle temporal gyrus (MTG.L), left superior temporal gyrus (STG.L), left postcentral gyrus (PoCG.L), and right middle frontal gyrus (MFG.R) compared with the TD group. Moreover, the ASD and ADHD groups exhibited no significant differences regarding regional connectivity characteristics. Second, the ADHD group showed significantly increased nodal betweenness centrality (Bi) of the left hippocampus (HIP.L) compared with the ASD group; also, compared with the ADHD group, the ASD group lacked the left anterior cingulate gyrus (ACG.L) as a hub. Last, decreased nodal efficiency (Enodal) of the AMYG.R, Ki of the AMYG.R, and Ki of the PHG.R were associated with higher SRS scores in the ASD group. Decreased Ki of the PHG.R was associated with higher SRS scores in the full sample, whereas decreased Bi of the PHG.R was associated with lower oppositional defiance subscale scores of the SNAP-IV in the ADHD group, and decreased Bi of the HIP.L was associated with lower inattention subscale scores of the SNAP-IV in the full sample.ConclusionFrom the perspective of the topological properties of brain WM structural networks, ADHD and ASD have both shared and distinct features. More interestingly, some shared and distinct topological properties of WM structures are related to the core symptoms of these disorders.

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Low dopamine D5 receptor density in hippocampus in an animal model of attention-deficit/hyperactivity disorder (ADHD)

Cited by 17 publications

References 94 publications

Regional Gray Matter Volume Differences Between Adolescents With ADHD and Typically Developing Controls: Further Evidence for Anterior Cingulate Involvement

Regional Gray Matter Volume Differences Between Adolescents With ADHD and Typically Developing Controls: Further Evidence for Anterior Cingulate Involvement

The Dopamine Receptor D5 May Influence Age of Onset

Shared and Distinct Topologically Structural Connectivity Patterns in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

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