“…The first concern related to 5th generation biosensors is catered by architecting advanced functional nanoplatforms and engineering their physicochemical attributes. Recently, two-dimensional (2D) nanomaterials, including graphene and its derivatives, metal carbides and nitrides (MXenes), metal borides (MBenes), metal-organic framework, metal dichalcogenides and borophene, due to their high specific surface area have emerged as excellent biosensing platforms with enhanced detection and monitoring efficacies ( Ahmed et al, 2020 ; Chakraborty et al, 2018 ; Chaudhary et al, 2022e , 2022a ; Dwivedi et al, 2021 ; Ho et al, 2021 ; Huang et al, 2020 ; Jiang et al, 2020 ; Naguib et al, 2021 ; Wu et al, 2022 ; Zha et al, 2019 ; H. Zhang et al, 2022 ) Amongst all, MXenes have demonstrated enormous potential in detecting and monitoring the diversified biomolecules utilizing various strategies, encompassing electrical, electronic, electrochemical, optical, acoustic and plasmonic modules ( Chaudhary et al, 2022a , 2022c , 2022e ; Sheth et al, 2022 ). It is attributed to the high effective surface area, tunable physicochemical attributes, and rich surface functionalities of MXenes, which contribute to enhanced monitoring performances.…”