Low-dimensional compounds containing bioactive ligands. V: Synthesis and characterization of novel anticancer Pd(II) ionic compounds with quinolin-8-ol halogen derivatives

Vranec, Peter; Potočňák, Ivan; Sabolová, Danica; Farkasová, Veronika; Ipóthová, Z; Jana, Pisarčiková; Paulíková, Helena

doi:10.1016/j.jinorgbio.2013.10.018

Cited by 27 publications

(8 citation statements)

References 34 publications

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“…The determined K SV values are close to the constants obtained for other zinc complex by Anjomshoa et al[93]. These measurements show that the interactions of 1-3 with DNA are strong, probably due to intercalative binding[72,92]. 3.3.4.…”

supporting

confidence: 88%

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Ag(I) and Zn(II) isonicotinate complexes: design, characterization, antimicrobial effect, and CT-DNA binding studies

Almáši

Vargová

Sabolová

et al. 2015

Journal of Coordination Chemistry

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Trinuclear Ag(I) (1) and dinuclear and mononuclear Zn(II) isonicotinate (2 and 3) complexes were prepared and characterized by X-ray crystallography, elemental analysis, IR spectroscopy and thermal analysis. Single crystal analysis of the Ag(I) complex reveals two different monodentate carboxylate coordination modes, protonated and deprotonated, respectively. IR spectra showed correlations between isonicotinate coordination modes and Δ(ν as -ν s ) IR values. In addition, the hydrogen bonds significantly influence a position of carboxylate absorption bands.Moreover, IC 50 and MIC data for bacteria, yeasts and filamentous fungi were determined and the binding of Ag(I) and Zn(II) complexes to calf thymus DNA was investigated using electronic absorption, fluorescence and CD measurements. Biological tests showed that the Ag(I) complex is more active than commercially used Ag(I) sulfadiazine against E. Coli. The fluorescence spectral results indicate that the complexes can bind to DNA through an intercalative mode. The Stern-Volmer quenching constants for investigated complexes obtained from the linear quenching plot are in the range of 1.67 × 10 4 to 3.42 × 10 4 M -1 .

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supporting

confidence: 88%

“…Upon addition of CT-DNA the absorption at 267 nm showed significant hypochromic effect (about 50%) and slight red shift of this maximum about 2 nm (figure 6). These phenomena indicate that the complex interacts with CT-DNA by intercalation [72]. Similar spectroscopic behavior was observed for 2 and 3.…”

Section: Electronic Absorption Spectrasupporting

confidence: 77%

Ag(I) and Zn(II) isonicotinate complexes: design, characterization, antimicrobial effect, and CT-DNA binding studies

Almáši

Vargová

Sabolová

et al. 2015

Journal of Coordination Chemistry

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“…Promising antitumor activity of platinum chelated compounds also has been described earlier [5,7]. Palladium compounds containing clioquinol were also reported to possess significant anticancer activity against ovarian cancer model [16]. However, NH3 is found to show superiority (in terms of IC 50 values) over the all previously reported results on activity of 8-Hydroxyquinoline, derivatives of 8-Hydroxyquinoline, metal chelated 8-Hydroxyquinoline or derivatives against various tumor models.…”

Section: Antitumor Activity Of the Complexmentioning

confidence: 62%

Promising Anticancer Activity of [Bis(1,8-quinolato)palladium (II)] Alone and in Combination

Alam

Moni

et al. 2021

IJMS

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Due to similar coordination chemistry of palladium and platinum, a large number of palladium compounds as well have been investigated for their anticancer activity. In the present study, we describe synthesis, characterization, and anticancer activity of palladium complex [Bis(1,8-quinolato) palladium (II)], coded as NH3 against seven different cancer cell lines. NH3 is found to have higher antitumor activity than cisplatin against both parent ovarian A2780 cell line and cisplatin-resistant cell lines. Also, NH3 has the lower IC50 value in HT-29 colorectal cancer cell line. The higher antitumor activity of NH3 is due to the presence of bulky 8-Hydroxyquinoline ligand, thus reducing its reactivity. Proteomic study has identified significantly expressed proteins which have been validated through bioinformatics. NH3 has been found to be less toxic than cisplatin at 2.5 mg/kg and 5 mg/kg dosages on mice models. Binary combinations of NH3 with curcumin and epigallocatechin gallate (EGCG) have demonstrated dose and sequence-dependent synergism in ovarian and colorectal cancer models. All of the preclinical studies indicate promising therapeutic potential of NH3 [Bis(1,8-quinolato) palladium (II)] as an anticancer drug.

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“…3 Furthermore, palladium complexes attract attention due to the biological proprieties. [4][5][6][7] A great variety of palladium complexes already exhibit significant cytotoxicity, in most cases surpasses the activity of platinum analogs. 8 The palladium(II) compounds containing pyrazole as ligands have been studied by Keter and it has been confirmed in vitro that these compounds cause apoptosis of cancer cells of human and ovarian fibroma of hamster.…”

Section: Introductionmentioning

confidence: 99%

“…These compounds affect the DNA structure and cause a low electrophoretic mobility. 10 Previous investigations in our laboratory have been devoted to the study of the molecular self-assembly via hydrogen bonds of pyrazolyl metal complexes of general formulae [MX 2 (HPz) 4 ] (M = Co(II), Ni(II); X = N 3 , SCN; HPz = pyrazole), 11 [PdX 2 (HdmPz) 2 ] (X = N 3 , SCN; HdmPz = 3,5-dimethylpyrazole), 12 and [Cd(μ-X) 2 (HPz) 2 ] n (X = Cl, SCN). 13 Particularly, we are interested in acquiring more information about the building blocks [PdCl 2 L 2 ] (L = 4-substituted pyrazoles) since the reaction of these compounds with azide ion gives rise to unusual coordination polymers instead of hydrogen-bonded supramolecular arrays.…”

Section: Introductionmentioning

confidence: 99%

Experimental and DFT study on the compounds [PdCl2L2] (L =4-methylpyrazole, 4-iodopyrazole)

Barra¹,

Treu-Filho²,

Rocha

et al. 2015

ACSi

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Theoretical molecular structures of the complexes [PdCl 2 (HmPz) 2 ] (1) and [PdCl 2 (HIPz) 2 ] (2) (HmPz = 4-methylpyrazole; HIPz = 4-iodopyrazole) were studied using B3LYP/DFT method. The new complex 2 and the complex 1 were synthesized and characterized by elemental analysis and IR spectroscopy. The calculated bond distances and angles showed that both compounds exhibited a slightly distorted square planar coordination environment around the palladium center. The theoretical IR spectra of C s symmetry (electronic state 1A') of the complexes agree well with the experimental data.

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Low-dimensional compounds containing bioactive ligands. V: Synthesis and characterization of novel anticancer Pd(II) ionic compounds with quinolin-8-ol halogen derivatives

Cited by 27 publications

References 34 publications

Ag(I) and Zn(II) isonicotinate complexes: design, characterization, antimicrobial effect, and CT-DNA binding studies

Ag(I) and Zn(II) isonicotinate complexes: design, characterization, antimicrobial effect, and CT-DNA binding studies

Promising Anticancer Activity of [Bis(1,8-quinolato)palladium (II)] Alone and in Combination

Experimental and DFT study on the compounds [PdCl2L2] (L =4-methylpyrazole, 4-iodopyrazole)

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