Low-Density Lipoprotein (LDL) Cholesterol is Cross-Sectionally Associated with Preclinical Chronic Kidney Disease (CKD) in Japanese Men

Oda, Eiji; Kawai, Ryu

doi:10.2169/internalmedicine.49.2792

Cited by 14 publications

(16 citation statements)

References 34 publications

(19 reference statements)

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“…Unadjusted negative association between cystatin C and TC has been previously reported [32]. Similarly to TC, and in agreement with earlier findings [33,34,35], all creatinine-based eGFRs were negatively associated with LDL-C. We did not observe any association when using eGFR Cys , again confirming earlier findings [32,36]. As for HDL-C, we could not confirm its association with creatinine-based eGFR, although the effect direction was concordant with previous studies [37,38], but we confirmed the previously reported association with cystatin C [32,36,39].…”

Section: Discussionsupporting

confidence: 91%

Estimating the Glomerular Filtration Rate in the General Population Using Different Equations: Effects on Classification and Association

Pattaro

Riegler

Stifter³

et al. 2013

Nephron Clin Pract

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Background/Aims: Several formulas for glomerular filtration rate (GFR) estimation, based on serum creatinine or cystatin C, have been proposed. We assessed the impact of some of these equations on estimated GFR (eGFR) and chronic kidney disease (CKD) prevalence, and on the association with cardiovascular risk factors, in a general population sample characterized by a young mean age. Methods: We studied 1,199 individuals from three Alpine villages enrolled into the MICROS study. eGFR was obtained with the 4- and 6-parameter MDRD study equations, the Virga equation, and with the three CKD-EPI formulas for creatinine, cystatin C, and the combination of creatinine and cystatin C. We assessed the concordance between quantitative eGFR levels, CKD prevalence, and in terms of association with total, LDL, and HDL cholesterol. Results: The highest and lowest eGFR levels corresponded to the cystatin C-based and MDRD-4 equations, respectively. CKD prevalence varied from 1.8% (Virga) to 5.8% (MDRD-4). The CKD-EPI based on creatinine showed the highest agreement with all other equations. Agreement between methods was higher at lower eGFR levels, older age, and in the presence of diabetes and hypertension. Creatinine-based estimates of eGFR were associated with total and low-density lipoprotein but not high-density lipoprotein cholesterol. The opposite was observed for the cystatin C-based GFR. Conclusion: GFR estimation is strongly affected by the chosen equation. Differences are more pronounced in healthy and younger individuals. To identify CKD risk factors, the choice of the equation is of secondary importance to the choice of the biomarker used in the formula. If eGFR is not calibrated to a gold standard GFR in the general population, reports about CKD prevalence should be considered with caution.

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Section: Discussionsupporting

confidence: 91%

Estimating the Glomerular Filtration Rate in the General Population Using Different Equations: Effects on Classification and Association

Pattaro

Riegler

Stifter³

et al. 2013

Nephron Clin Pract

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“…However, recently, at least crosssectionally, Oda and Kawai reported that in Japanese men, the levels of LDL-C increased significantly in relation to the stage of chronic kidney disease (CKD), 6 which contradicts the previously reported data.…”

Section: Replymentioning

confidence: 80%

Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients – Reply –

Kiyosue

Hirata

2010

Circ J

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“…And elevated BUN and creatinine indicate the impairment of kidney function [26]. Besides, another study revealed that low HDL-C, high TC, and triglyceride levels can lead to renal damage, and demonstrated that the increased levels of LDL-C were independently related to chronic kidney disease in Japanese men [27].…”

Section: Discussionmentioning

confidence: 99%

Associations between <b><i>Apolipoprotein E</i></b> Gene Polymorphisms and Cardiovascular Complications of Uremic Patients on Maintenance Hemodialysis

Cai

Shu³

et al. 2018

Blood Purif

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This study is to investigate the associations between apolipoprotein E (ApoE) gene polymorphisms and cardiovascular complications of uremic patients on maintenance hemodialysis (MHD). Uremic patients on MHD (189, case group) and healthy people (165, control group) were recruited. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to test ApoE gene polymorphisms. Indicators of MHD and cardiovascular complications were observed. Compared with the control group, the case group had decreased frequency of ε3/3 genotype and ε3 allele and increased ε4/3 genotype and ε4 allele. The ε4 group had elevated adiponectin, serum creatinine, blood urea nitrogen, and total cholesterol but decreased HDL-C compared with other groups. The ε3 group had reduced complications. ApoE ε3 and ε4 alleles were related with cardiovascular complications of the uremic patients on MHD. We concluded that ApoE gene polymorphisms were associated with susceptibility to infections in uremia, and that ApoE ε3 and ε4 alleles might correlate with cardiovascular complications of uremic patients on MHD.

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Low-Density Lipoprotein (LDL) Cholesterol is Cross-Sectionally Associated with Preclinical Chronic Kidney Disease (CKD) in Japanese Men

Abstract: Background Low-density lipoprotein (LDL)

Cited by 14 publications

References 34 publications

Estimating the Glomerular Filtration Rate in the General Population Using Different Equations: Effects on Classification and Association

Estimating the Glomerular Filtration Rate in the General Population Using Different Equations: Effects on Classification and Association

Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients – Reply –

Associations between <b><i>Apolipoprotein E</i></b> Gene Polymorphisms and Cardiovascular Complications of Uremic Patients on Maintenance Hemodialysis

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