Low-density lipoprotein cholesterol to apolipoprotein B ratio predicts mortality and cardiovascular events in peritoneal dialysis patients

Zeng, Chuanfei; Qu, Zhan; Lv, Linghai; Chen, Yanbing; Zhan, Xiaojiang

doi:10.1007/s11255-023-03514-3

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Gelsolin was pointed out that closely related with the occurrence of some cancers, whose high expression could promote liver cancer cell proliferation and invasive ( 38 ). Apolipoprotein B levels could indicate the risk of coronary heart disease ( 39 , 40 ), chronic kidney disease ( 41 ), and its high-expression may accelerate disease progression.…”

Section: Discussionmentioning

confidence: 99%

Proteomics Clustering Research of ITRAQ Markers in Plasma of AIDS Patients with Different Chinese Medicine Syndromes

Zhang,

Qiu,

et al. 2024

ijph

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Background: We aimed to distinguish the different Chinese medicine (CM) syndromes of acquired immune deficiency syndrome (AIDS) patients at the proteomics level. Methods: We collected AIDS patients diagnosed with different CM syndromes from Weishi County, Kaifeng City, Henan Province, China, including Qi-deficiency syndrome (named QD group) and dampness-heat syndrome (named DH group). Healthy people were collected as controls from Weishi County, Kaifeng city, Henan Province, China. The plasma from three groups were labeled with ITRAQ, LC/MC was used for protein quantitative analysis. Finally, sequence search and cluster analysis were performed. Results: Overall, 27 different proteins were found. Three proteins were up-regulated and 2 proteins down-regulated in the QD group, 11 proteins up-regulated and 13 proteins down-regulated in the DH group. Compared with DH group, there were 7 different proteins in QD group, among which 5 proteins were down-regulated and 2 proteins were up-regulated. When the target protein of DH group was up-regulated, the protein of HC group was down-regulated correspondingly. Conclusion: The significance analysis and clustering of protein results showed that DH group was significantly different from QD group and HC group at the protein level (P<0.05). However, the QD group could not be effectively distinguished from the HC group. AAT, PF4, C-reactive protein and c4bp may be used as potential biomarkers in DH group. Mass spectrometry based on feature selection can be used to classify different CM syndromes.

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Section: Discussionmentioning

confidence: 99%

Proteomics Clustering Research of ITRAQ Markers in Plasma of AIDS Patients with Different Chinese Medicine Syndromes

Zhang,

Qiu,

et al. 2024

ijph

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“…In recent years, LDL-C and LYM in combination with other biomarkers have been a hot topic for clinical disease risk factor analysis. For example, for LDL-C, the LDL-C to apolipoprotein B (apo B) ratio had been demonstrated to be independently associated with all-cause mortality and cardiovascular events in peritoneal dialysis patients [ 39 ], and The High-density lipoprotein cholesterol (HDL-C) to LDL-C ratio can be applied to early assessment of disease severity and outcome in patients with acute pancreatitis admitted to ICU [ 40 ]. As for LYM, the Platelet Count to LYM Ratio has excellent diagnostic power in predicting periprosthetic joint infection in patients undergoing total knee arthroplasty (TKA) [ 41 ], while the fibrinogen to LYM ratio has been established as a new prognostic indicator for patients after radical hepatocellular carcinoma operation [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Low-density lipoprotein cholesterol-to-lymphocyte count ratio (LLR) is a promising novel predictor of postoperative new-onset deep vein thrombosis following open wedge high tibial osteotomy: a propensity score-matched analysis

Guo,

Li,

et al. 2024

Thrombosis J

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Background The association of low-density lipoprotein cholesterol (LDL-C) and lymphocyte counts with the development of deep vein thrombosis (DVT) has been demonstrated in many fields but remains lacking in open wedge high tibial osteotomy (OWHTO). This study aimed to assess the predictive value of LDL-C to lymphocyte count ratio (LLR) in screening for postoperative new-onset DVT. Methods Clinical data were retrospectively collected from patients who underwent OWHTO between June 2018 and May 2023. The limited restricted cubic spline (RCS) was conducted to evaluate the nonlinear relationship between LLR and the risk of postoperative new-onset DVT. The receiver operating characteristic (ROC) curves were plotted and the predictive value of biomarkers was assessed. After adjusting for intergroup confounders by propensity score matching, the univariate logistic regression was applied to assess the association between LLR and DVT. Results 1293 eligible patients were included. RCS analysis showed a linear positive correlation between LLR and the risk of DVT (P for overall = 0.008). We identified LLR had an area under the curve of 0.607, accuracy of 74.3%, sensitivity of 38.5%, and specificity of 80.7%, and LLR > 1.75 was independently associated with a 1.45-fold risk of DVT (95% CI: 1.01–2.08, P = 0.045). Furthermore, significant heterogeneities were observed in the subgroups of age, BMI, diabetes mellitus, hypertension, Kellgren-Lawrence grade, the American Society of Anesthesiologists (ASA) score, and intraoperative osteotomy correction size. Conclusion LLR is a valuable biomarker for predicting postoperative new-onset DVT in patients with OWHTO, and routine screening is expected to yield positive benefits.

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Low-density lipoprotein cholesterol to apolipoprotein B ratio predicts mortality and cardiovascular events in peritoneal dialysis patients

Cited by 2 publications

References 38 publications

Proteomics Clustering Research of ITRAQ Markers in Plasma of AIDS Patients with Different Chinese Medicine Syndromes

Proteomics Clustering Research of ITRAQ Markers in Plasma of AIDS Patients with Different Chinese Medicine Syndromes

Low-density lipoprotein cholesterol-to-lymphocyte count ratio (LLR) is a promising novel predictor of postoperative new-onset deep vein thrombosis following open wedge high tibial osteotomy: a propensity score-matched analysis

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