Low-Density Lipoprotein Cholesterol and the Risk of Rheumatoid Arthritis: A Prospective Study in a Chinese Cohort

VanEvery, Hannah; Yang, Wenhao; Su, Jinmei; Olsen, Nancy J.; Bao, Le; Wu, Shouling; Gao, Xiang

doi:10.3390/nu14061240

Cited by 6 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, medical workers should pay attention to evaluate the overall impact of elevated blood lipid levels on cardiovascular risk in elderly patients with RA complicated with anemia due to the control of inflammation. It is suggested that blood lipids and inflammatory indexes in elderly RA patients should be monitored regularly, and corrective measures should be taken in time when the baseline blood lipid levels decrease significantly, so as to avoid further deterioration of the RA and anemia [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Anemia in elderly rheumatoid arthritis patients: a cohort study

Sun,

Shao,

Liu

et al. 2023

Arch Med Sci

View full text Add to dashboard Cite

IntroductionAnemia is common in elderly patients with rheumatoid arthritis (RA). This study aimed to evaluate the current status and influencing factors of anemia in RA patients, to provide insights for clinical RA treatment and care.Material and methodsThis study included elderly patients with high RA activity treated in our hospital from June 1, 2021 to December 31, 2022 for analysis. The characteristics of RA patients were analyzed. Pearson correlation and logistic regression analysis were conducted to analyze the influencing factors of anemia in elderly patients with RA.ResultsA total of 285 RA patients were included. The incidence of anemia in high RA activity patients was 62.46%. There were significant differences in the course of RA, hemoglobin (Hb), low density lipoprotein cholesterol (LDL-C), platelet/lymphocyte rate (PLR) and albumin (Alb) between RA patients with anemia and without anemia (all p < 0.05). Pearson correlation analysis indicated that course of RA (r = 0.522), Hb (r = 0.797), LDL-C (r = 0.558), PLR (r = 0.615) and Alb (r = 0.604) were correlated with anemia in patients with high RA activity (all p < 0.05). Logistic regression analysis indicated that course of RA ≥ 8 years (OR = 2.584, 95% CI: 1.822–3.647), LDL-C ≤ 2.8 mmol/l (OR = 3.202, 95% CI: 2.804–3.431), PLR ≥ 8 (OR = 2.183, 95% CI: 1.744–2.457), Alb ≤ 35 g/l (OR = 1.716, 95% CI: 1.401–2.006) were the risk factors of anemia in elderly patients with high RA activity (all p < 0.05).ConclusionsAnemia in elderly patients with high RA activity is closely related to the course of RA, LDL-C, PLR and Alb. Close attention should be paid to the monitoring of those indicators to take early intervention measures to improve the prognosis of RA patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Anemia in elderly rheumatoid arthritis patients: a cohort study

Sun,

Shao,

Liu

et al. 2023

Arch Med Sci

View full text Add to dashboard Cite

show abstract

“…According to the previously published articles and relevant clinical experience ( 23 ), the confounding factors that may affect the relationship between dietary live microbes and arthritis were controlled. The main covariates are as follows: Age is categorized into two groups: < 60 years old, and 60 years old and above.…”

Section: Methodsmentioning

confidence: 99%

Exploratory analysis on the relationship between dietary live microbe intake and arthritis: a national population based cross-sectional study

Liu,

Xing,

Kong

2024

Front. Nutr.

View full text Add to dashboard Cite

ObjectiveThe pathogenesis of arthritis such as rheumatoid arthritis (RA) and osteoarthritis (OA) remains unclear. This study aims to investigate whether the intake of live dietary microbes can be used as an auxiliary means for the treatment of arthritis.MethodsData used in the present research were originated from the US National Health and Nutrition Examination Survey (NHANES) from 2003–2018. Participants involved in the present study were categorized into three groups based on the dietary live microbe classification system, namely low, medium, and high dietary live microbe groups. The analyses utilized weighted univariate and multivariate logistic regression. The restricted cubic spline plot was used to explore the relationship between the high dietary live microbe group and the odds of arthritis.Results12,844 participants were included in the present study. The intake of high live dietary microbes in RA group was lower than that in healthy control group and OA group. The proportion of RA patients in the high live dietary microbe group was lower than that in the low and medium live dietary microbe group. Following the comprehensive adjustment for covariates, it was observed that participants in both the high and medium dietary live microbe groups exhibited lower odds of RA compared to those in the low dietary live microbe group (High OR: 0.71, 95% CI: 0.53–0.96; Medium OR: 0.77, 95% CI: 0.59–1.00, p = 0.02). A restricted cubic spline plot indicates a negative correlation between the quantity of dietary live microbes and the occurrence of RA within the high dietary live microbe group.ConclusionThe results of our study revealed a significant difference in dietary live microbe intake between healthy and RA patients. Higher dietary intake was correlated with a decreased odds of RA. However, no significant association was found between the occurrence of OA and the quantity of dietary live microbes.

show abstract

“…To control for potential confounders, we included the following covariates:Age[18], Gender [2], Ethnicity [2], Education [19], Income [2], Smoke [20], Alcohol [21,22], BMI [23], Hypertension [24], High Cholesterol [25], bloodglucose [26]. These confounders were chosen to consider possible associations with the prevalence of RA.…”

Section: Other Covariates Used In Nhanesmentioning

confidence: 99%

Association between total protein, albumin, globulin, albumin- globulin ratio and rheumatoid arthritis: evidence from NHANES and Mendelian randomization

Liu,

Zhang,

Zhao

et al. 2024

Preprint

View full text Add to dashboard Cite

Background With the increasing incidence of rheumatoid arthritis (RA) and the increasing percentage of serum RF negativity, there is an urgent need for more and more accurate methods for the early diagnosis and prevention of RA, among which serum proteins are closely related to the development of RA and are expected to become new auxiliary diagnostic tools, but their relationship with RA is not clear, so this study aimed to investigate the causal relationship between total protein (TP), albumin (ALB), globulin ( GLB), and albumin-globulin ratio (A/G) on the causal relationship of rheumatoid arthritis (RA). Methods In this study, the relationship between TP, ALB, GLB, A/G and rheumatoid arthritis was comprehensively evaluated by generalized linear modeling and smoothed curve fitting through the data of serum proteins and RA in the NHANES(National Health and Nutrition Examination Survey) database; moreover, for the positive results with significant associations, the inverse variance weighted (IVW) method in Mendelian Randomization (MR) was used in conjunction with the other four methods to further validate and clarify the causative relationship, and finally, the results were subjected to the inspection of heterogeneity and horizontal polytomousness in order to assess whether the results were robust. Results In the observational study, after correction for confounders, TP, GLB, and A/G were not significantly associated with rheumatoid arthritis, whereas ALB was significantly negatively associated with rheumatoid arthritis (OR = 0.662, [95%CI = 0.507–0.864], P = 0.003), and subgroup analyses showed significant negative associations in both males and females (male : OR = 0.674, [95%CI = 0.458–0.991], P = 0.047; females: OR = 0.661, [95%CI = 0.437–0.999], P = 0.049). In further MR analysis, IVW: ALB on RA, OR = 0.70 [95%0.52–0.93], P = 0.013; RA on ALB, OR = 0.95 [95%CI = 0.93–0.98], P < 0.001.The results of the MR analyses remained consistent with NHANES. Conclusion There is a significant relationship between ALB and RA, and the reduction of ALB may be one of the risk factors for RA, as well as one of the outcomes in the development of RA.

show abstract

Low-Density Lipoprotein Cholesterol and the Risk of Rheumatoid Arthritis: A Prospective Study in a Chinese Cohort

Cited by 6 publications

References 29 publications

Anemia in elderly rheumatoid arthritis patients: a cohort study

Anemia in elderly rheumatoid arthritis patients: a cohort study

Exploratory analysis on the relationship between dietary live microbe intake and arthritis: a national population based cross-sectional study

Association between total protein, albumin, globulin, albumin- globulin ratio and rheumatoid arthritis: evidence from NHANES and Mendelian randomization

Contact Info

Product

Resources

About