Low-density lipoprotein cholesterol and risk of intracerebral hemorrhage

Abstract

ObjectiveTo prospectively examine the association between low-density lipoprotein (LDL) cholesterol (LDL-C) concentrations and intracerebral hemorrhage (ICH) risk.MethodsThe current cohort study included 96,043 participants (mean age 51.3 years) who were free of stroke, myocardial infarction, and cancer at baseline (2006). Serum LDL-C concentrations were assessed in 2006, 2008, 2010, and 2012. Cumulative average LDL-C concentrations were calculated from all available LDL-C data during that period. Incident ICH was confirmed by review of medical records.ResultsWe identified 753 incident ICH cases during 9 years of follow-up. The ICH risk was similar among participants with LDL concentrations of 70 to 99 mg/dL and those with LDL-C concentrations ≥100 mg/dL. In contrast, participants with LDL-C concentrations <70 mg/dL had a significantly higher risk of developing ICH than those with LDL-C concentrations of 70 to 99 mg/dL; adjusted hazard ratios were 1.65 (95% confidence interval [CI] 1.32–2.05) for LDL-C concentrations of 50 to 69 mg/dL and 2.69 (95% CI 2.03–3.57) for LDL-C concentrations <50 mg/dL.ConclusionsWe observed a significant association between lower LDL-C and higher risk of ICH when LDL-C was <70 mg/dL, and the association became nonsignificant when LDL-C ≥70 mg/dL. These data can help determination of the ideal LDL range in patients who are at increased risk of both atherosclerotic disease and hemorrhagic stroke and guide planning of future lipid-lowering studies.

Association between tea consumption and cognitive impairment in middle-aged and older adults

“…The Asymptomatic Polyvascular Abnormalities in Community (APAC) study is a cross-sectional, community-based, and observational investigation designed to explore the epidemiology of asymptomatic polyvascular abnormalities in Chinese adults. The APAC study population was a part of the previously described Kailuan cohort [ 16 , 17 ], with 101,510 participants (18–98 years old). In 2010, 7000 participants aged over 40 were randomly selected from the Kailuan study by a random sampling method stratified by age and sex.…”

In utero exposure to the Great Chinese Famine and risk of intracerebral hemorrhage in midlife

“…Assessments of ICH incidence were conducted once a year during the follow-up period from 2006 to 2015, as detailed elsewhere. 16,17 Potential ICH incidence was ascertained from 4 complementary sources: (1) Municipal Social Insurance Institution, which covered all study participants; (2) Hospital Discharge Register centers; (3) death certificates; and (4) questionnaire survey (biennially since 2006). Potential cases of ICH included those who were identified by the ICD-10 based on the first 3 sources or those who self-reported as having ICH in the questionnaire survey.…”

Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage

“…Various forms of cell death have been identified after ICH, including apoptosis, necrosis, and autophagy in humans and experimental animals, and autophagic cell death in animal models [31][32][33]. Although inhibiting apoptosis, necrosis, and autophagy can improve outcomes in animals subjected to experimental ICH, no successful clinical trials using cell-death inhibitor monotherapy have been reported [34][35][36]. These facts suggest that multiple forms of cell death other than those mentioned above may occur after ICH and contribute collectively to neuronal death.…”