Low cost Raman sample substrates from conductive silver paint smear for Raman spectroscopic screening of metabolic diseases in whole blood

Birech, Zephania; Ondieki, Annah M.; Opati, Robert I.I.; Mwangi, Peter Waweru

doi:10.1016/j.vibspec.2020.103063

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Generally, smear tests offer new noninvasive or minimally invasive detection options as they allow detection with sparse biological tissue and require less tissue than slices. However, the development of smear substrates is a complicated and lengthy process, and researchers are constantly attempting to develop substrates with low spectral impact (Birech et al., 2020; Otange et al., 2017). Additionally, substrates that provide uniform Raman spectra, without the need to consider the excitation wavelength, are expensive and beyond the affordability of many laboratories.…”

Section: Methodsmentioning

confidence: 99%

“…The addition of "silver paste/paint" on the surface of a material for Raman spectroscopy is considered SERS, which is a common practice to enhance the Raman signals. Similarly, Birech et al (2020) reported low-cost smear substrates coated with conductive silver paint that are useful in screening metabolic diseases of whole blood samples through Raman spectroscopy. By applying blood onto a glass slide coated with conductive silver paint, Raman signals were enhanced by a factor of 1.7 in comparison to the thick blood smears on regular glass slides.…”

Section: Application Of Raman Spectroscopy In Ex Vivo Tissue Detectionmentioning

confidence: 99%

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Applications of Raman spectroscopy in clinical medicine

Qi,

Chen,

et al. 2024

Food Frontiers

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Raman spectroscopy is a nondestructive and highly effective technique for analyzing biological tissues and diagnosing diseases by providing detailed spectral information about the specific molecular structures of substances. Its efficacy in these applications has been widely recognized, making it a powerful tool in the field. This article presents a comprehensive overview of the latest developments in Raman spectroscopy and its wide‐ranging applications in the diagnosis of critical diseases, such as cancer, infections, neurodegenerative diseases, and predicting surgical outcomes. It highlights the significant contributions of Raman spectroscopy in these areas, shedding light on its potential as a valuable diagnostic tool. This article delves into the advancements of Raman spectroscopy in biomedical sciences, with a specific focus on state‐of‐the‐art techniques such as surface‐enhanced Raman spectroscopy, resonance Raman spectroscopy, and tip‐enhanced Raman spectroscopy. These techniques have shown great potential in various applications within the field. The article explores their use in ex vivo and in vivo medical diagnosis, covering topics such as sample collection, data processing, and the successful establishment of correlations between Raman spectra and biochemical information in specific diseases. Furthermore, the article discusses the limitations of the current research and offers insights into potential future directions for further exploration in the field of Raman spectroscopy in biomedical sciences.

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Section: Methodsmentioning

confidence: 99%

Section: Application Of Raman Spectroscopy In Ex Vivo Tissue Detectionmentioning

confidence: 99%