Low-cost instrumentation of Automated Whole – slide Microscope for Biomedical Imaging

Pechprasarn, Suejit; Sukkasem, Chayanisa; Suvarnaphaet, Phitsini; Thongchoom, Rujirada; Chuwittaya, Suteeboon; Janyasupab, Metini

doi:10.1109/bmeicon.2018.8609942

Cited by 2 publications

(3 citation statements)

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“…As can be noticed, a bulk of the reports is focused on bright field microscopy, implemented in a stop-and-focus manner. [63][64][65][66][67][68][69][70][71][72][73][74][75] Some of these systems also support fluorescence imaging 63,64,66,[74][75][76] and even phase 66,77 or polarization 75 imaging. These modalities (especially fluorescent imaging) are of vital importance in applications such as immunohistochemistry-based tests that detect widely prevalent disorders such as cancer.…”

Section: Comparison Of Recent Research Reportsmentioning

confidence: 99%

“…There are only few reports of systems that require manual positioning. 55,79 Since many systems use 3-D printed parts, 55,61,67,79 their cost is far lower than the ones using off-the-shelf opto-mechanical components. However, the positional accuracy (especially along the optical axis) is a concern for the low-cost systems and thus they need to implement stop-and-focus scanning.…”

Section: Comparison Of Recent Research Reportsmentioning

confidence: 99%

“…Most devices use low-cost digital control boards and externally interfaced displays. 55,61,67 The overall low-power components imply that most of these systems can be run on battery power. 61 There are several reports of computational microscopy being used for slide imaging.…”

Section: Comparison Of Recent Research Reportsmentioning

confidence: 99%

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Recent technical advances in whole slide imaging instrumentation

Katare

Gorthi

2021

Journal of Microscopy

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Microscopic observation of biological specimen smears is the mainstay of diagnostic pathology, as defined by the Digital Pathology Association. Though automated systems for this are commercially available, their bulky size and high cost renders them unusable for remote areas. The research community is investing much effort towards building equivalent but portable, low‐cost systems. An overview of such research is presented here, including a comparative analysis of recent reports. This paper also reviews recently reported systems for automated staining and smear formation, including microfluidic devices; and optical and computational automated microscopy systems including smartphone‐based devices. Image pre‐processing and analysis methods for automated diagnosis are also briefly discussed. It concludes with a set of foreseeable research directions that could lead to affordable, integrated and accurate whole slide imaging systems.

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