Low Conversion Rate to Multiple Sclerosis in Idiopathic Optic Neuritis Patients in Taiwan

Lin, Yuan-Mao; Yen, May-Yung; Hsu, Wen-Ming; Lee, Hui Chen; Wang, An Guor

doi:10.1007/s10384-005-0281-1

Cited by 48 publications

(67 citation statements)

References 30 publications

(48 reference statements)

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“…We found that the mean annual incidence of MS in Taiwan was 0.085 per 1,000 persons, and the cumulative incidence (or cumulative probability) of MS conversion was 0.78% over the 5 years of our study. In Asian countries [10,23,25] , and in African populations [26] , the conversion rates are relatively low compared with those in Western countries. Both ethnic and regional factors may play a role in the wide range of MS conversion rates in various countries [27,28] .…”

Section: Discussionmentioning

confidence: 99%

“…It can be the initial presentation of MS, or it can occur later in the course of the disease. However, the conversion percentage varies widely (6.5-75%) over an observational period of 3 years or longer [4,5,10,[22][23][24] . The wide range of conversion rates from different studies is probably due to differences in the lengths of follow-up and to the lack of uniform diagnostic criteria for MS. Another reason may be the low prevalence and incidence of MS in Taiwan.…”

Section: Discussionmentioning

confidence: 99%

“…In other parts of the world, data about conversion rates are sparse. However, notably low rates of conversion have been reported in Japan (8.3%) [8] , Mexico (12%) [9] and Taiwan (14.3%) [10] .…”

Section: Introductionmentioning

confidence: 99%

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Optic Neuritis among National Health Insurance Enrollees in Taiwan, 2000–2004

Woung

Lin²,

Tsai³

et al. 2007

Neuroepidemiology

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Background: The objective was to examine the incidence of optic neuritis in Taiwan. A 5-year longitudinal, nationwide, population-based study was conducted. The participants were a random sample of 191,761 subjects, or about 1% of the enrollees in the National Health Insurance program of Taiwan. Methods: We identified subjects who had at least 1 service claim for ambulatory or inpatient care with a principal diagnosis of optic neuritis between 2000 and 2004. We calculated and statistically analyzed the rates of optic neuritis. The main outcome measures were the incidence rates of optic neuritis. Results: From 2000 to 2004, the total cumulative incidence was 1.33 per 1,000 (1.00 vs. 1.67 for male vs. female subjects; p < 0.001, χ² test). The cumulative incidence rates for the age groups of 0–19, 20–39, 40–59 and ≧60 years were 0.33, 1.05, 2.16 and 2.81 cases per 1,000, respectively. Among the subjects aged 40–59 years, the cumulative incidence was higher in women than in men (p < 0.001, χ² test). The incidence density of developing multiple sclerosis after optic neuritis was 0.41% per person-year, and the cumulative incidence of multiple sclerosis after a new diagnosis of optic neuritis was 0.78%. Conclusions: We believe our study is the first nationwide investigation of the incidence rates of optic neuritis in Taiwan. In our investigation, the cumulative incidence peaked among the subjects aged 40–59 years, especially in women. In Taiwan, patients with optic neuritis have a notably low rate of conversion to multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Optic Neuritis among National Health Insurance Enrollees in Taiwan, 2000–2004

Woung

Lin²,

Tsai³

et al. 2007

Neuroepidemiology

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“…Some factors are significantly predictors of secondary evolution of optic neuritis to multiple sclerosis (p<0.05), in particular: female sex, retrobulbar type of optic neuropathy, recurrence, elevation of the IgG index in cerebrospinal fluid and the existence of signal abnormalities in cerebral imaging [14]. The two year cumulative probability of secondary transformation from optic neuritis to multiple sclerosis is estimated to be 5.92% and that of five years to 14.28% [14].…”

Section: Discussionmentioning

confidence: 99%

“…The two year cumulative probability of secondary transformation from optic neuritis to multiple sclerosis is estimated to be 5.92% and that of five years to 14.28% [14].…”

Section: Discussionmentioning

confidence: 99%

Bilateral and Simultaneous Retrobulbar Optic Neuritis Revealing Multiple Sclerosis

Bouomrani¹,

Belgacem²,

Rekik³

et al. 2017

J Mult Scler

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Optic neuritis is a common manifestation of multiple sclerosis. It occurs in two thirds of patients at some point in the course of this disease and is usually unilateral, acute and often recurrent. However, optic neuritis can be the first manifestation of this demyelinating disease in 15 to 20% of cases.Bilateral, simultaneous and retrobulbar forms of optic neuritis inaugurating multiple sclerosis remain exceptional and unusual. They represent a real diagnostic challenge and require special attention from the clinician Herein we report the case of bilateral simultaneous and isolated retrobulbar optic neuritis inaugurating multiple sclerosis in a 24 year old woman.

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Acute Optic Neuritis

Wang

2018

Emergency Neuro-Ophthalmology

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Low Conversion Rate to Multiple Sclerosis in Idiopathic Optic Neuritis Patients in Taiwan

Cited by 48 publications

References 30 publications

Optic Neuritis among National Health Insurance Enrollees in Taiwan, 2000–2004

Optic Neuritis among National Health Insurance Enrollees in Taiwan, 2000–2004

Bilateral and Simultaneous Retrobulbar Optic Neuritis Revealing Multiple Sclerosis

Acute Optic Neuritis

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