Low concentrations of lead disturb phenotypical markers of the inflammatory and the anti-inflammatory profile of bone marrow-derived macrophages from BALB/c mice

Ortiz-Robles, Christian D.; Cortés-Montoya, Vanessa; Reyes-Aguilar, Sandra S.; Albores, Arnulfo; Calderón-Aranda, Emma S.

doi:10.1016/j.tox.2021.152885

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…In contrast, Pb increased TGF-β1 and mannose receptor (CD206) expression in IL4/IL-13-stimulated BMDM. This might explain the susceptibility to allergic diseases reported in subjects exposed to Pb [ 99 ]. Another study used THP-1-derived macrophages to evaluate the cellular effects of Pb nanoparticles.…”

Section: Effects Of Heavy Metals On Macrophage Polarizationmentioning

confidence: 99%

Role of Macrophages in Air Pollution Exposure Related Asthma

Tsai

Chiou

et al. 2022

IJMS

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Asthma is a chronic inflammatory airway disease characterized by variable airflow obstruction, bronchial hyper-responsiveness, and airway inflammation. The chronic inflammation of the airway is mediated by many cell types, cytokines, chemokines, and inflammatory mediators. Research suggests that exposure to air pollution has a negative impact on asthma outcomes in adult and pediatric populations. Air pollution is one of the greatest environmental risks to health, and it impacts the lungs’ innate and adaptive defense systems. A major pollutant in the air is particulate matter (PM), a complex component composed of elemental carbon and heavy metals. According to the WHO, 99% of people live in air pollution where air quality levels are lower than the WHO air quality guidelines. This suggests that the effect of air pollution exposure on asthma is a crucial health issue worldwide. Macrophages are essential in recognizing and processing any inhaled foreign material, such as PM. Alveolar macrophages are one of the predominant cell types that process and remove inhaled PM by secreting proinflammatory mediators from the lung. This review focuses on macrophages and their role in orchestrating the inflammatory responses induced by exposure to air pollutants in asthma.

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Section: Effects Of Heavy Metals On Macrophage Polarizationmentioning

confidence: 99%

Role of Macrophages in Air Pollution Exposure Related Asthma

Tsai

Chiou

et al. 2022

IJMS

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“…However, Pb's effect on the monocyte/macrophage cells of the hematopoietic system has not been of significant focus, though monocyte/macrophage cells have their origins in the bone-marrow, and are implicated in the pathology of various immune related diseases throughout the body. When the role of Pb on the immune response of monocyte/macrophage cells has been investigated, most studies involved the use of LPS to simulate infection or inflammation through TNF-alpha (TNF-α) induction (18)(19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Potential Immunomodulatory Role of Lead in Monocyte/Macrophage Differentiation

Nicholson

Schanne

2023

Preprint

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Lead (Pb) is a pernicious toxic metal and public health hazard, as it persists in the environment contaminating soil, food, and drinking water. Lead exerts its toxic effect on numerous organ systems, with the abundance of focus on the red blood cells and neurons of the hematopoietic and central nervous systems. However, insufficient investigation has been conducted on the effect of Pb on immune cells. In the current study, the toxic effects of Pb on immune cells of monocyte/macrophage lineage are described. Pb exerts a dose-dependent alteration in differentiation of monocyte/macrophage cells that retain some plasticity in development. Pb induces a bifurcation in differentiation of monocyte/macrophage cells, resulting in inhibition of osteoclastogenesis and induction of dendritic cells (DC). This phenomenon was demonstrated in RAW 264.7 murine monocyte/macrophage cell line and was consistent with response in rat bone-marrow derived macrophage (Sprague-Dawley). Pb primarily produced this response through induction of GM-CSF production and inhibition of p38/MAPK activity. Long-term exposure to physiologically relevant concentrations of Pb has the potential to modulate the immune system through altering the cell-lineage commitment of monocyte/macrophage lineage cells in a dose-dependent manner. Thus, Pb may function as an immunomodulator.

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