We consider a finitely generated graded module M over a standard graded commutative Noetherian ring R = d 0 R d and we study the local cohomology modules H i R + (M) with respect to the irrelevant ideal R + of R. We prove that the top nonvanishing local cohomology is tame, and the set of its minimal associated primes is finite. When M is Cohen-Macaulay and R 0 is local, we establish new formulas for the index of the top, respectively bottom, nonvanishing local cohomology. As a consequence, we obtain that the (S k )-loci of a Cohen-Macaulay R-module M, regarded as an R 0 -module, are open in Spec(R 0 ). Also, when dim(R 0 ) 2 and M is a Cohen-Macaulay R-module, we prove that H i R + (M) is tame, and its set of minimal associated primes is finite for all i.