Abstract:Background: Increasing adropin levels in old mice improves cognition. Adropin expression in human brain samples correlates with pathways affecting cognition. Whether circulating adropin levels correlate with cognition in advanced age is not known. Methods: Plasma adropin concentrations were measured in 452 participants of the Multidomain Alzheimer Preventive Trial (MAPT; ClinicalTrials.gov Identifier,NCT00672685; mean age 75.8y, SD=4.5y, 60.2% female). Cognitive ability was assessed using a composite cognitive… Show more
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