Low CCL2 and CXCL8 Production and High Prevalence of Allergies in Children with Microcephaly Due to Congenital Zika Syndrome

Abstract

Congenital Zika Syndrome (CZS) is associated with an increased risk of microcephaly in affected children. This study investigated the peripheral dysregulation of immune mediators in children with microcephaly due to CZS. Gene expression quantified by qPCR in whole blood samples showed an increase in IFNγ and IL-13 transcripts in children affected with microcephaly compared to the control group. The microcephaly group exhibited significantly decreased CCL2 and CXCL8 levels in serum, quantified by CBA assay. An allergic profile questionnaire revealed a high prevalence of allergies in the microcephaly group. In accordance, elevated serum IgE level measured by the Proquantum Immunoassay was observed in children affected with microcephaly compared to the control group. Altogether, these findings show a persistent systemic inflammation in children with microcephaly due to CZS and suggest a possible impairment in leukocyte migration caused by low production of CCL2 and CXCL8, in addition to high levels of IgE associated with high prevalence of allergies. The dysregulation of inflammatory genes and chemokines underscores the importance of understanding the immunological characteristics of CZS. Further investigation into the long-term consequences of systemic inflammation in these children is crucial for developing appropriate therapeutic strategies and tailored vaccination protocols.

IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

“…IL-8 plays a crucial role in attracting neutrophils, and a deficiency in CXCL8 can impair the movement of these cells to tissues [361]. For example, children suffering from microcephaly because of Congenital Zika Syndrome showed a significant decrease in serum IL-8 levels, leading to an impairment in leukocyte migration [361].…”

“…IL-8 plays a crucial role in attracting neutrophils, and a deficiency in CXCL8 can impair the movement of these cells to tissues [361]. For example, children suffering from microcephaly because of Congenital Zika Syndrome showed a significant decrease in serum IL-8 levels, leading to an impairment in leukocyte migration [361]. On the other hand, a rise in the absolute neutrophil count and IL-8 levels in the bloodstream were linked to the severity of COVID-19, wherein plasma IL-8 levels were associated with mortality [362].…”