Low bone mineral density is associated with dyslipidemia in South Korean men: The 2008–2010 Korean National Health and Nutrition Examination Survey

Kim, Yang Hyun; Nam, Ga Eun; Cho, Kyung Hwan; Choi, Youn Seon; Kim, Seon Mee; Han, Byung Duck; Han, Kyung Do; Lee, Kyung Shik; Park, Chang Hae; Kim, Do Hoon

doi:10.1507/endocrj.ej13-0224

Cited by 33 publications

(17 citation statements)

References 54 publications

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“…However, studies also show that at low concentrations, oxLDL has the opposite effect and may promote osteoblast proliferation[37]. These contradictory, concentration-dependent actions of oxLDL may explain some inconsistent results of studies examining the association of LDL-c and BMD[7, 13–23]. Further studies of oxLDL, LDL-related apolipoproteins and bone metabolism in humans are needed.…”

Section: Discussionmentioning

confidence: 99%

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

et al. 2015

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Purpose Studies of lipid and lipoprotein cholesterol associations with bone mineral density (BMD) and bone loss have been inconclusive, and longitudinal data are sparse. Therefore, the aim of this study was to test if fasting serum lipid and lipoprotein cholesterol levels are associated with areal and volumetric BMD and BMD change, Methods We determined the association of serum triglycerides, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol concentrations with cross-sectional and longitudinal (mean follow-up: 6.1 years) measures of BMD in a cohort of 1289 in African ancestry men (mean age: 56.4 years). Fasting serum triglycerides, HDL and LDL were measured at baseline concurrent with BMD assessments. Dual-energy X-ray absorptiometry was used to quantify integral hip BMD and peripheral quantitative computed tomography at the radius and tibia was used to quantify volumetric BMD. Men were categorized as optimal, borderline or high-risk for triglyceride, HDL and LDL concentrations based on adult treatment panel III guidelines. Results Lower serum triglyceride or LDL and higher HDL concentrations were associated with lower trabecular BMD at baseline (all p<0.05). Similarly, men classified as having optimal levels of LDL, HDL or triglycerides at baseline experienced the greatest integral BMD loss at the hip and trabecular BMD loss at the tibia (all p<0.05), independent of potential confounding factors. Conclusions We found that clinically optimal serum lipid and lipoprotein cholesterol concentrations were associated with accelerated bone loss among Afro-Caribbean men. Further studies are needed to better understand the mechanisms involved and potential clinical significance of these findings.

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Section: Discussionmentioning

confidence: 99%

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

et al. 2015

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“…Orozco and colleagues found that postmenopausal women with atherogenic lipid profiles (fasting state) have lower BMD at the lumbar, total hip and femoral neck bones than those with normal lipid profile. 26, 27 In another study, lumbar and whole body BMD correlated inversely with lipid levels (above the atherogenic threshold) in postmenopausal women, but not in premenopausal women or postmenopausal women on hormone replacement therapy (HRT), 28 suggesting that HRT use should be taken into consideration due to the known anti-inflammatory effects of estrogen. When the subjects were not fasted prior to blood collection or when the lipid levels were below the atherogenic threshold, a weak or even a positive association between serum lipid levels and BMD was found.…”

Section: Biological Lipids and Lipoproteinsmentioning

confidence: 99%

Effects of bioactive lipids and lipoproteins on bone

Tintut

Demer

2014

Trends in Endocrinology & Metabolism

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Although epidemiological studies from the past two decades show a link between atherosclerotic vascular disease and bone loss, that is independent of age, the mechanism is still unclear. This review focuses on evidence that suggests a role for atherogenic lipids and lipoproteins in the pathogenesis of bone loss, including direct effects of these bioactive lipids/lipoproteins on bone cells, inhibiting osteoblastic differentiation and promoting osteoclastic differentiation. It also addresses recent evidence that suggests that bioactive lipids blunt the effects of bone anabolic agents, such as teriparatide and bone morphogenetic proteins. The role of systemic and intracellular oxidant stress and inflammation in mediating the effects of bioactive lipids/lipoproteins are implicated.

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“…The risk factors for the development of osteoporosis are old age, postmenopausal women, low calcium intake, low vitamin D level, and health behaviors such as smoking, alcohol intake, and physical activities [8][9][10]. Cardiometabolic abnormalities including dyslipidemia and metabolic syndrome are also known to be associated with the prevalence of osteoporosis [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Oral health behaviors and bone mineral density in South Korea: the 2008–2010 Korean National Health and Nutrition Examination Survey

Kim

Cho

et al. 2015

J Bone Miner Metab

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The purpose of this study was to examine the association between oral health behaviors and bone mineral density (BMD) by using data from the Korean National Health and Nutrition Examination Survey conducted in 2008-2010. We included 6,620 subjects (3,140 men aged more than 50 years and 3,480 postmenopausal women). BMD was measured at three sites-namely, the lumbar spine, total femur, and femur neck. Oral health behaviors were assessed by use of a self-administered questionnaire in the Korean National Health and Nutrition Examination Survey. After adjustment for all covariates, BMD of the lumbar spine and femur neck tended to increase as the frequency of tooth brushing increased in men (p trend = 0.020 and p trend = 0.028, respectively). Women using secondary oral products had increased lumbar spine BMD compared with women who did not use secondary oral products. However, after adjustment for all covariates, no significant relationship was observed between BMD and the use of secondary oral products. As the frequency of tooth brushing and the number of secondary oral products used increased, the prevalence of osteoporosis decreased. The frequency of tooth brushing is associated with increased lumbar spine and femur neck BMD in South Korean men.

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Low bone mineral density is associated with dyslipidemia in South Korean men: The 2008–2010 Korean National Health and Nutrition Examination Survey

Cited by 33 publications

References 54 publications

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

Effects of bioactive lipids and lipoproteins on bone

Oral health behaviors and bone mineral density in South Korea: the 2008–2010 Korean National Health and Nutrition Examination Survey

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