Low Bone Mineral Density and Impaired Bone Metabolism in Young Alcoholic Patients Without Liver Cirrhosis: A Cross‐Sectional Study

Malík, Peter; Gasser, R.; Kemmler, Georg; Moncayo, Roy; Finkenstedt, G; Kurz, Martin; Fleischhacker, W. Wolfgang

doi:10.1111/j.1530-0277.2008.00847.x

Cited by 84 publications

(57 citation statements)

References 30 publications

(36 reference statements)

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“…Researches from Austria and Europe showed that chronic heavy alcohol use, especially during adolescence and young adult years by interfering calcium absorption, can dramatically affect bone health and increase the risk of osteoporosis later in life (Malik et al, 2009;De Vernejoul et al, 1983). However, this study observed alcohol intake had no significant association with the development of osteoporosis; this may be attributed to the fact that many people hesitate to tell the truth about the frequency and amount of alcohol intake due to high religiosity in the study area.…”

Section: Discussioncontrasting

confidence: 73%

Risk factors of osteoporosis among adults in Ethiopia, the case of Tigrai region: A case control study

Alemayehu¹,

Enqueselassie²,

Zenebe³

et al. 2014

J. Public Health Epidemiol.

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Osteoporosis is one of the most common public health problems affecting adults and elderlies in developing countries. This study aims to examine the potential risk factors of osteoporosis among adults in Tigrai, Northern Ethiopia. This is a case-control study. Cases and controls were assigned by two radiologists after radiographic examination of the wrist. An interviewer administered questionnaire was used and information on demographic characteristics and potential risk factors were collected. Data was processed and analyzed using statistical package for social sciences (SPSS) version 19. Binary logistic regression was used to control confounders. A total of 130 osteoporotic cases and 266 controls participated in the study. The mean ± standard deviation (SD) age of cases and controls were 60.9 ± 10.1 and 46.9 ± 8.7 years, respectively. The multivariate analysis adjusted for age and sex showed that rural residents were 1.93 times more likely to develop osteoporosis than the urban inhabitants with an adjusted odds ratio (AOR) 1.93 (95% CI, 1.11, 3.36). The strongest association was also found when the work of the respondent involves decreased physical activity with AOR 3.53 (95% CI, 1.98 and 6.30). Furthermore, milk consumption greater than four times a week and smoking showed a significant association with the AOR 0.33 (95% CI, 0.19 and 0.58), and AOR 0.17 (95% CI, 0.05 and 0.58), respectively. Residing in the rural setting and smoking were positively associated with osteoporosis. In contrast, milk intake greater than four times a week, and when work involves vigorous exercise, appeared to be associated with a reduced risk of osteoporosis. Therefore, the findings from the study suggest the need for changes of lifestyle that includes encouraging adults to stop smoking, engage in vigorous physical activities aging and adequate dietary intake including milk. Strategies to identify and manage osteoporosis in the primary health care setting need to be established.Key words: Case control, osteoporosis, risk factors, bone mineral density, DR-F digital radiography, Ethiopia. INTRODUCTIONThe patient profile in health institutions all over the developing world is changing. Non-communicable diseases (NCDs) have already established themselves as the predominant cause of disease and death in many middle-income countries including Ethiopia (WHO 2010).Osteoporosis is one of the non-communicable diseases defined as a skeletal disorder characterized by low bone density and micro-architectural deterioration of bony tissue *Corresponding author. E-mail: alemayehub35@gmail.com. Conference, 1991). It is one of the most common public health problems in adults and older people worldwide (Ross 1996). It is a common silent disease affecting both women and men over the age of 50 years. A significant number of clinical symptoms associated with osteoporosis become evident only after the occurrence of hip, vertebral, or wrist fractures. These fractures lead to many problems such as mortality, morbidity, and economic problems to individuals...

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Section: Discussioncontrasting

confidence: 73%

Risk factors of osteoporosis among adults in Ethiopia, the case of Tigrai region: A case control study

Alemayehu¹,

Enqueselassie²,

Zenebe³

et al. 2014

J. Public Health Epidemiol.

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“…Epidemiological studies in alcoholics of both genders report significant decreases in bone mineral density (BMD) and increased bone fractures and osteoporosis risk compared with nondrinkers (Clark et al, 2003;Malik et al, 2009;Pasoto et al, 2011;Wuermser et al, 2011), which is related to changes in bone turnover, particularly decreased bone formation and increased bone resorption (Dai et al, 2000;Alvisa-Negrín et al, 2009;Callaci et al, 2010;Díez-Ruiz et al, 2010). Previously, we have reported significant decreases in tibial and femoral BMD after chronic ethanol (EtOH) consumption in cycling female rats receiving isocaloric diets via intragastric infusion [total enteral nutrition (TEN)] Chen et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Supplementation Protects against Bone Loss Associated with Chronic Alcohol Administration in Female Mice

Mercer

Wynne

Lazarenko

et al. 2012

J Pharmacol Exp Ther

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Chronic alcohol abuse results in decreased bone mineral density (BMD), which can lead to increased fracture risk. In contrast, low levels of alcohol have been associated with increased BMD in epidemiological studies. Alcohol's toxic skeletal effects have been suggested to involve impaired vitamin D/calcium homeostasis. Therefore, dietary vitamin D supplementation may be beneficial in reducing bone loss associated with chronic alcohol consumption. Six-week-old female C57BL/6J mice were pair-fed ethanol (EtOH)-containing liquid diets (10 or 36% total calories) for 78 days. EtOH exposure at 10% calories had no effects on any measured bone or serum parameter. EtOH consumption at 36% of calories reduced BMD and bone strength (P Ͻ 0.05), decreased osteoblastogenesis, increased osteoclastogenesis, suppressed 1,25-hydroxyvitamin D 3 [1,25(OH) 2 D 3 ] serum concentrations (P Ͻ 0.05), and increased apoptosis in bone cells compared with pair-fed controls. In a second study, female mice were pair-fed 30% EtOH diets with or without dietary supplementation with vitamin D 3 (cholecalciferol; VitD) for 40 days. VitD supplementation in the EtOH diet protected against cortical bone loss, normalized alcohol-induced hypocalcaemia, and suppressed EtOHinduced expression of receptor of nuclear factor-B ligand mRNA in bone. In vitro, pretreatment of 1,25(OH) 2 D 3 in osteoblastic cells inhibited EtOH-induced apoptosis. In EtOH/ VitD mice circulating 1,25(OH) 2 D 3 was lower compared with mice receiving EtOH alone (P Ͻ 0.05), suggesting increased sensitivity to feedback control of VitD metabolism in the kidney. These findings suggest dietary VitD supplementation may prevent skeletal toxicity in chronic drinkers by normalizing calcium homeostasis, preventing apoptosis, and suppressing EtOH-induced increases in bone resorption.

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“…Insufficiency of vitamin D and decrease of sexual steroids like magnesium and phosphate, are also related. These hormones are commonly known to have positive effects on osteoblasts [17,18].…”

Section: Discussionmentioning

confidence: 99%

http://medcraveonline.com/JOENTR/volume_issues?issueId=1343&volumeId=415

P¹,

ini²,

Lourenço³

et al. 2017

JOENTR

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Alcohol is widely consumed in the world. Excessive alcohol intake causes alterations in bone tissues. The objective of this paper is to review the effects of chronic alcohol use in bone microarchitecture and the mechanisms by which this abuse may decrease bone mineral density. Furthermore, in the second part of the review, it's related the different techniques to induce bone loss in rats by alcoholization.Objectives: The aim of this paper is to review in the recent literature the negative effects of chronic alcohol intake in bone health and the mechanisms responsible for that. It's also review the different techniques available for experimental alcohol-induced osteopenia in rodents. Methods:Pubmed database was systematically searched to obtain all the eligible papers, published in English language, covering the period between 1997 and 2014. The literature search combined several key words including: bone, alcoholism, cortical bone, ethanol, bone density, rat and animal models.Results: A total of thirty-eight articles were selected in Pubmed database, considering the key words aforementioned. In the review, it is included twentynine articles published in English, in the period between 1997 and 2014.

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Low Bone Mineral Density and Impaired Bone Metabolism in Young Alcoholic Patients Without Liver Cirrhosis: A Cross‐Sectional Study

Cited by 84 publications

References 30 publications

Risk factors of osteoporosis among adults in Ethiopia, the case of Tigrai region: A case control study

Risk factors of osteoporosis among adults in Ethiopia, the case of Tigrai region: A case control study

Vitamin D Supplementation Protects against Bone Loss Associated with Chronic Alcohol Administration in Female Mice

http://medcraveonline.com/JOENTR/volume_issues?issueId=1343&volumeId=415

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