Low Bone Density in Systemic Sclerosis. A Systematic Review

Omair, Mohammed A.; Pagnoux, Christian; McDonald-Blumer, Heather; Johnson, Sindhu R.

doi:10.3899/jrheum.130032

Cited by 72 publications

(74 citation statements)

References 37 publications

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“…Several studies have shown a potentially reduced bone mineral density in women with scleroderma compared to control women. A recent systematic literature review summarized data about the prevalence of low bone mineral density and its risk factors in scleroderma [64]. The search resulted in ten studies, which reported a lower bone mineral density in patients with scleroderma compared to matched controls, while two studies reported no difference.…”

Section: Reviewmentioning

confidence: 99%

Rheumatic autoimmune diseases in women and midlife health

Marder

Vinet

Somers

2015

womens midlife health

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Autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (scleroderma) preferentially affect women, and are characterized by systemic inflammation leading to target organ dysfunction. The public health burden of autoimmune diseases, which collectively represent a leading cause of morbidity and mortality among women throughout adulthood, is substantial. While some features of these diseases have been observed to improve over the menopausal transition, such as disease flare rate in SLE and skin softening and thinning in scleroderma, others, such as swollen and tender joints and radiographically confirmed damage in RA may worsen. The general trends, however, are not consistent or conclusive for all disease-related manifestations. Of great importance is the recognition that comorbid diseases, including osteoporosis and accelerated cardiovascular disease, contribute excess morbidity and mortality that becomes increasingly apparent as women with autoimmune diseases undergo the menopausal transition.

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Section: Reviewmentioning

confidence: 99%

Rheumatic autoimmune diseases in women and midlife health

Marder

Vinet

Somers

2015

womens midlife health

View full text Add to dashboard Cite

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“…Increased fracture risk has been identified in other rheumatic conditions such as RA, but this is yet to be confirmed in SSc. 27 …”

Section: Manifestations Of Systemic Sclerosismentioning

confidence: 97%

Musculoskeletal Manifestations of Systemic Sclerosis

Morrisroe

Nikpour

Proudman

2015

Rheumatic Disease Clinics of North America

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“…Ob Patienten mit der diffusen Form der systemischen Sklerose tiefere Knochendichtewerte aufweisen als Patienten mit der umschriebenen Form, ist umstritten. Das Frakturrisiko ist bei Patienten mit systemischer Sklerose wahrscheinlich ebenfalls erhöht, Daten dazu fehlen jedoch weitgehend [16,18,28].…”

Section: Systemische Skleroseunclassified

Entzündlich-rheumatische Erkrankungen als Risikofaktoren für Osteoporose

Frey¹

2014

Gynäkologische Endokrinologie

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Low Bone Density in Systemic Sclerosis. A Systematic Review

Abstract: The data suggest that patients with SSc are at risk of low BMD and fracture, especially when other risk factors for OP are present. The interaction of SSc manifestations, traditional OP risk factors, and clinically relevant outcomes is complex and warrants further research.

Cited by 72 publications

References 37 publications

Rheumatic autoimmune diseases in women and midlife health

Rheumatic autoimmune diseases in women and midlife health

Musculoskeletal Manifestations of Systemic Sclerosis

Entzündlich-rheumatische Erkrankungen als Risikofaktoren für Osteoporose

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