Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer

Avilés‐Jurado, Francesc Xavier; Terra, Ximena; Gómez, David Rodríguez; Flores, Joan Carles; Raventós, Antoni; Maymó-Masip, Elsa; León, Xavier; Serrano-Gonzalvo, Vicente; Vendrell, Joan; E, Figuerola; Chacón, Matilde R.

doi:10.1007/s00405-014-3095-2

Cited by 13 publications

(27 citation statements)

References 34 publications

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“…Moreover, we found a close correlation between low‐circulating levels of sTWEAK and low survival rates in a cohort of 37 patients with HNSCC. In the present study, we externally validated the sTWEAK levels as a prognostic biomarker in patients with HNSCC and confirmed a significant association between low pretreatment sTWEAK and poor clinical outcome, as we previously described …”

Section: Discussionsupporting

confidence: 87%

External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma

et al. 2015

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Section: Discussionsupporting

confidence: 87%

External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma

et al. 2015

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“…In all probability, there is a constant or continued TWEAK‐Fn14 activation which may be accountable for increased expression in tumors. Gene expression analysis of TWEAK‐Fn14 in OSCC tissues found a gradual significant increase in the expression pattern of these molecules from control to cancerous tissues . In most analyses, TWEAK expression is increased in tumor tissues compared with normal, which may trigger the proliferation or migration activity .…”

Section: Discussionmentioning

confidence: 99%

“…Hence, TWEAK may contribute to progression of tumors . TWEAK‐Fn14 upregulates vascular endothelial growth factor expression to promote ovarian cancer metastasis and regulates the invasive capacity of breast cancer cells …”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical expression of tumor necrosis factor‐like weak inducer of apoptosis and fibroblast growth factor‐inducible immediate early response protein 14 in oral squamous cell carcinoma and its implications

Acharya

Prabhu

Patil

et al. 2019

J of Invest & Clin Dent

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Aim To study the expression of tumor necrosis factor‐like weak inducer of apoptosis (TWEAK) and fibroblast growth factor‐inducible immediate early response protein 14 (Fn14) in oral squamous cell carcinoma (OSCC), to elucidate the possible role of TWEAK‐Fn14 in OSCC development. Methods Immunohistochemistry for TWEAK‐Fn14 was performed on 61 oral mucosal samples: healthy oral mucosa (HOM; N = 15); oral dysplastic lesions (ODL; N = 15); and OSCC (N = 31). Extent of staining (ES) and immunoreactive score (IRS) were assessed. The data was statistically analyzed. Results All OSCC expressed TWEAK, and the Fn14 expression was noted in 90% of OSCC. A significant difference in the TWEAK and Fn14 expression was noted among the groups. ES and IRS of TWEAK‐Fn14 significantly increased in OSCC compared with ODL and HOM. ES of TWEAK was significantly higher than Fn14 in all 3 groups. ES of TWEAK‐Fn14 was significantly higher at the invasive tumor front (ITF) than in the whole tumor. TWEAK‐Fn14 showed a significant association with clinicopathological parameters of prognostic significance. Conclusion Findings suggest that TWEAK and Fn14 may participate in the growth and progression of OSCC. Increased expression of TWEAK‐Fn14 at the ITF may facilitate increased proliferation, altered differentiation and invasion.

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“…There are studies in the literature reporting the association of low serum sTWEAK concentrations with poor outcomes in other cancers but to our knowledge, this is the first study in the literature reporting the association of serum sTWEAK concentration with mortality in HCC patients. 24,25 There are certain limitations of the current study. First, sample size was relatively small.…”

Section: Discussionmentioning

confidence: 99%

Serum Soluble TWEAK Concentration is Decreased in Patients with Hepatocellular Cancer and Low Blood Levels of sTWEAK are Associated with Poor Survival.

Asıl¹

2017

UHOD

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Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily and has been implicated in the pathogenesis of several cancers. This study was conducted to investigate serum sTWEAK levels and its relation with prognosis in patients with hepatocellular carcinoma (HCC). Twenty-eight cirrhotic patients with HCC, 28 patients with cirrhosis and 30 healthy subjects were included in the study. Serum sTWEAK concentrations were measured by using commercially available enzyme-linked immune sorbent assay kits. Mean serum sTWEAK concentrations in HCC, cirrhosis and healthy control groups were 174.0±69.9 pg/ml, 221.4±61.2 pg/ml and 288.0±68.4 pg/ml respectively and the difference between the groups was statistically significant (p< 0.001). Mean sTWEAK concentration in the HCC group was significantly lower than both cirrhosis group (p= 0.009) and healty controls (p< 0.001). In the ROC curve analysis, AUC for serum TWEAK concentration to predict one-year mortality in HCC patients was 0.836 (95% CI: 0.684-0.987) and for the specified cut-off value of 148.1 pg/ml, sensitivity and specificity were 66.7% and 92.3% respectively. Kaplan-Meier survival estimates showed that, survival rate was significantly lower in patients with serum sTWEAK< 148.1 pg/ml (log-rank test, chi-square= 11.75, p= 0.001). Serum sTWEAK concentration was identified as an independent predictor of mortality in Cox regression analysis (Hazard ratio= 4.325, %95 CI: 1.080-17.326, p= 0.025). Serum sTWEAK concentration is decreased in HCC patients. Lower serum sTWEAK concentrations at the time of diagnosis are associated with poor prognosis and higher one-year mortality rates in HCC patients.Keywords: Tumor necrosis factor-like weak inducer of apoptosis, Hepatocellular cancer, Survival rate, Mortality ÖZET Serum Solubl TWEAK Konsantrasyonu Hepatoselüler Kanser Hastalarında Azalmıştır ve Düşük Kan sTWEAK Düzeyleri Kötü Sağkalımla İlişkilidirTumor necrosis factor-like weak inducer of apoptosis (TWEAK) tümör nekrozis factor ailesinin bir üyesidir ve birçok kanserin patogenezinde rol oynadığı öne sürülmüştür. Bu çalışmada hepatoselüler kanser (HCC) hastalarında serum sTWEAK düzeylerinin araştırılması amaçlanmıştır. Yirmi sekiz HCC hastası, 28 siroz hastası ve 30 sağlıklı kontrol çalışmaya dahil edilerek serum sTWEAK konsantrasyonları ELISA yöntemiyle hazır kitler kullanılarak çalışılmıştır. HCC, siroz ve sağlıklı kontrol gruplarında ortalama serum sTWEAK konsantrasyonları 174.0±69.9 pg/ml, 221.4±61.2 pg/ml ve 288.0±68.4 pg/ml olup gruplar arasındaki fark istatistiksel olarak anlamlıydı (p< 0.001). HCC grubundaki ortalama sTWEAK konsantrasyonunun gerek siroz (p= 0.009) gerek de sağlıklı kontrol (p< 0.001) gruplarından daha düşük olduğu görüldü. ROC analizinde, sTWEAK için 1 yıllık mortaliteyi öngörme açısından eğri altında kalan alan 0.836 (%95CI: 0,684-0,987) ve belirlenen148,1 pg/ml eşik değeri için duyarlılık ve özgüllük %66.7 ve %92.3 olarak bulundu.Kaplan-Meier sağkalım analizi ile serum sTWEAK konsantrasyon...

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Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer

Cited by 13 publications

References 34 publications

External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma

External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma

Immunohistochemical expression of tumor necrosis factor‐like weak inducer of apoptosis and fibroblast growth factor‐inducible immediate early response protein 14 in oral squamous cell carcinoma and its implications

Serum Soluble TWEAK Concentration is Decreased in Patients with Hepatocellular Cancer and Low Blood Levels of sTWEAK are Associated with Poor Survival.

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