Low blood lead concentration in association with infertility in women

Chang, Shu‐Hao; Cheng, Bi-Hua; Lee, Su-Long; Chuang, Hung‐Yi; Yang, Chih‐Jen; Sung, Fung‐Chang; Wu, Trong-Neng

doi:10.1016/j.envres.2005.10.004

Cited by 84 publications

(60 citation statements)

References 42 publications

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“…No association was suggested for FF Hg, Cd or Pb concentrations and biochemical pregnancy during multivariable regression in the aforementioned Saudi Arabian IVF study [7]; in fact the unadjusted association suggested a 'borderline significant' increase in pregnancy for each 1 μg/ L increase in FF Hg (OR01.17, 95%CI 0.98-1.40). However, a cross-sectional study of women attending an infertility or a postpartum clinic reported a higher odds for infertility among women with blood Pb exceeding 2.5 μg/ dL [9]. Furthermore, a recent prospective study of 501 couples conceiving unassisted [8] reported a 22 % reduced probability for conception per 1 μg/L increase in blood Cd adjusted for blood Hg, blood Pb and covariates (OR00.78 95%CI 0.63-0.97), yet no association for Hg or Pb.…”

Section: Associations Between Metals and Pregnancymentioning

confidence: 96%

“…Yet, the results from studies assessing reproductive toxicity associated with trace exposures to Hg, Cd and Pb in women have been inconsistent. Studies report decreased fecundity or fertility [7][8][9][10][11][12], no association [13,14], or even increased fecundity [7,15] in association with higher exposures. In our studies, we conducted preliminary evaluations of trace metal concentrations measured in blood and urine specimens collected from women undergoing in vitro fertilization (IVF), and reported associations between blood Pb and oocyte maturity [16,17], urine Cd and oocyte fertilization [17], blood Pb level and embryo cleavage [18], and blood Hg and Cd and embryo implantation [19].…”

Section: Introductionmentioning

confidence: 99%

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Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Bloom

Kim

Kruger

et al. 2012

J Assist Reprod Genet

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Purpose We previously reported associations between trace concentrations of Hg, Cd and Pb in blood and urine and reproductive outcomes for women undergoing in-vitro fertilization (IVF). Here we assess measurements in single follicular fluid (FF) specimens from 46 women as a presumably more relevant marker of dose for reproductive toxicity. Methods FF specimens were analyzed for Hg, Cd and Pb using sector field-inductively coupled plasma-mass spectrometry (SF-ICP-MS). Variability sources were assessed by nested ANOVA. Multivariable regression was used to evaluate associations for square root transformed metals with IVF outcomes, adjusting for confounders.

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Section: Associations Between Metals and Pregnancymentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Bloom

Kim

Kruger

et al. 2012

J Assist Reprod Genet

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“…17,19 Chang et al found that average Pb levels in blood were 35.5±14 μg/L in infertile and 27.8±21 μg/L in fertile women. 20 In the present study, the Pb levels in WB were 39.8±14 μg/L and 29.2±16 μg/L in the infertile and control groups, respectively. Lead levels in CM were similar in the infertile (17.3±5 μg/L) and control (16±4.4 μg/L) groups.…”

Section: Discussionmentioning

confidence: 84%

“…Our findings were also similar to the blood Pb levels previously reported for infertile cases. 20,21 Cervical mucus Pb levels were 19.3±5.3 μg/L in those with ovulatory disorders, 17.2±5.1 μg/L in those with tubal factors and 15.4±4.3 μg/L in those with unexplained infertility.…”

Section: Discussionmentioning

confidence: 99%

Association of Between Heavy Metal and Trace Element Levels in Blood and Cervical Mucus with Female Infertility

Ilgin¹,

Hassa²,

Karataş³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Infertility affects 10-15% of couples during the reproductive period. Ovulatory disorders are more common in younger women whereas unexplained infertility occurs more commonly in older women. Recently, many environmental agents, such as cigarettes, alcohol, heat, electromagnetic energy and radiation have been shown to have negative effects on the reproductive system. Environmental factors and exposure to heavy metals change fertility patterns in adults by affecting germ cell maturation, fertilization and the endocrine system. We aimed to investigate the effect of trace elements and heavy metals in blood and cervical mucus on female infertility. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Study was performed with 50 women: Infertile (n=35) and controls (n=15). Blood and cervical mucus samples were collected to measure Zn, Cu, Cd, and Pb levels. R Re es su ul lt ts s: : Mean blood plasma and cervical mucus Zn, Cd, and Cu levels in the infertile group were significantly lower than those in the control group. Whole blood Pb level was higher in the infertile group compared to the control group. Although blood Cd level tended to be higher in smokers and cervical mucus Cd level tended to be lower in controls, neither of these difference were statistically significant. C Co on nc cl lu us si io on n: : Lower levels of plasma and cervical mucus Zn and Cu were thought to result from higher levels of Cd and Pb in blood and cervical mucus. Abnormal levels of heavy metals in blood and cervical mucus may have adverse effects on the female reproductive function.K Ke ey y W Wo or rd ds s: : Cervix mucus; metals, heavy; trace elements; infertility, female Ö ÖZ ZE ET T A Am ma aç ç: : İnfertilite, üreme çağındaki çiftlerin %10-15' ini etkilemektedir. İleri yaşlarda daha yaygın olarak açıklanamayan infertilite, genç kadınlarda ise ovulatuvar rahatsızlık gözlenmektedir. Son zamanlarda, sigara, alkol, ısı, elektromanyetik enerji ve radyasyon gibi çok sayıda çevresel ajanın üreme sistemine olumsuz etkisi olduğu gösterilmiştir. Çevresel faktörler ve ağır metallere maruz kalma, germ hücre olgunlaşmasını, döllenmeyi ve endokrin sistemi etkileyerek erişkinlerde doğurganlık durumunu etkilemektedir. Bu çalışmada kan ve servikal mucusta eser elementlerin ve ağır metallerin kadın infertilitesi üzerine etkisini araştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma 35 infertil ve 15 kontrol, toplam 50 kadın ile gerçekleştirildi. Zn, Cu, Cd ve Pb düzeylerini ölçmek için kan ve servikal mucus örnekleri toplandı. B Bu ul lg gu ul la ar r: : Ortalama kan plazması ve servikal mucus Zn, Cd, ve Cu düzeyleri infertil grupta kontrol grubuna göre anlamlı olarak düşüktü. Tam kan kurşun düzeyi infertil grupta kontrol grubundan daha yüksekti. Sigara içenlerde kan Cd düzeyi daha yüksek ve kontrol grubunda servikal mucus Cd düzeyi daha düşük olma eğiliminde olmasına rağmen, her iki farklılık da istatistiksel olarak anlamlı değildi. S So on nu uç ç: : Plazma...

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“…The World Health Organization estimates that approximately 8% of couples, or 50 -80 million people worldwide, have some forms of infertility [1]. In industrialized countries, 10% -15% of married couples have had either primary or secondary infertility experiences [2].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Microbiome Collected from the Reproductive Tracts of Women from Saudi Arabia and Its Potential Influence on Infertility

Alrezaki¹,

Aldahmash²,

Alwassel³

et al. 2017

ARSci

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Background and Objective: Female infertility may be attributed to several causes that are fundamentally related to the health status of women. The main objective of this project was to correlate the abundance of the microbiota in cervicovaginal fluid to infertility. Materials & Methods: A total of 36 married women who voluntarily came to the hospital in Riyadh for a routine visit participated in the study. To collect the cervicovaginal liquid, a Softcup™ menstrual device was used by the participant; the cup was then transported in a liquid nitrogen box to the laboratory for analysis. Results: The mean vaginal pH in normal women and infertile women was 3.96 and 5.06, respectively, and the difference between the two cohorts was significant (p < 0.0001). The results showed a clear correlation between the pH value and the floral species detected in the cervicovaginal liquid. In fact, normal flora is primarily composed of a heterogeneous group of Lactobacillus species that have been detected at pH range 3.0 -4.5, whereas a second group of bacteria mainly composed of Gardnerella vaginalis, Peptostreptococcus anaerobius and L. iners has been detected in a pH range between 4.5 and 5.5. The third group, with a pH range >5.5, is primarily composed of G. vaginalis, P. anaerobius, Mycoplasma hominis, Mobiluncus species and Atopobium vaginae. The protein content and viscosity of the cervicovaginal liquid were significantly lower in infertile women compared to normal women (p < 0.05).

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Low blood lead concentration in association with infertility in women

Cited by 84 publications

References 42 publications

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes

Association of Between Heavy Metal and Trace Element Levels in Blood and Cervical Mucus with Female Infertility

Assessment of the Microbiome Collected from the Reproductive Tracts of Women from Saudi Arabia and Its Potential Influence on Infertility

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