Low Blood Content of IL-10-Producing CD4+ T Cells as a Risk Factor for Progression of Coronary Atherosclerosis

Filatova, A.Y.; Pylaeva, Ekaterina; Потехина, А В; Ruleva, N. Yu.; Klesareva, E.; Radyukhina, N. V.; Масенко, В П; Shchinova, A M; Ноева, Е А; Проваторов, С И; Афанасьева, О. И.; Aref'eva, T I

doi:10.1007/s10517-019-04344-z

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…Treg cells were decreased in patients with acute coronary syndrome [155, 156], but not in stable coronary disease compared to control patients [156]. However, a recent study in patients with stable coronary disease evidenced progression of atherosclerosis when CD4 + IL10 + Treg cell blood levels were below 3.3% [157]. Furthermore, the Treg cell count was reduced in patients with mild carotid atherosclerosis [158].…”

Section: Targeting Early Atherosclerosismentioning

confidence: 99%

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

Marchio

Guerra-Ojeda

Vila

et al. 2019

Oxidative Medicine and Cellular Longevity

457

316

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Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. Oxidation of low-density lipoprotein (LDL) cholesterol is one of the key factors for the development of atherosclerosis. Nonoxidized LDL have a low affinity for macrophages, so they are not themselves a risk factor. However, lowering LDL levels is a common clinical practice to reduce oxidation and the risk of major events in patients with cardiovascular diseases (CVD). Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. The atherosclerotic process is accelerated by a myriad of factors, such as the release of inflammatory chemokines and cytokines, the generation of reactive oxygen species (ROS), growth factors, and the proliferation of vascular smooth muscle cells. Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. In this review, we focus on early stages of the disease and we address both biomarkers and therapeutic approaches currently available and under research.

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Section: Targeting Early Atherosclerosismentioning

confidence: 99%

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

Marchio

Guerra-Ojeda

Vila

et al. 2019

Oxidative Medicine and Cellular Longevity

457

316

View full text Add to dashboard Cite

show abstract

“…Continual secretion of IL-6 plays a pathological effect on chronic inflammation [48]. It has been reported that low content of IL-10-producing CD4 + T cells is a risk factor for progression of coronary AS [49] and evoking TGF-β1-mediated anti-inflammatory response inhibited AS progression [50]. Besides, RES increased the secretion of IL-2 in CD4 + T cells.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Ameliorates Atherosclerosis Induced by High-fat Diet and LPS in ApoE-/- Mice and Inhibits the Activation of CD4+ T Cells

Zhou

Long

Sun

et al. 2020

Preprint

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Background: Atherosclerosis (AS), which characterized with the accumulation of lipids on the vessel wall, is the pathological basis of many cardiovascular diseases (CVD) and seriously threatens human health. Resveratrol (RES) has been reported to be benefit for AS treatment. This research aimed to observe the effects of RES on AS induced by high-fat diet (HFD) and LPS in ApoE-/- mice and investigate the underlying mechanism.Methods: ApoE-/- mice were fed with HFD companied with LPS to induce AS and RES was administrated for 20 weeks. Splenic CD4+ T cells were cultured and treated with anti-CD3/CD28 together with LPS, and RES was added. Serum lipids and the atherosclerotic areas of aortas were detected. The activation of CD4+ T cells were investigated both in vivo and in vitro and the expression of DNA methyltransferases (Dnmt) in CD4+ T cells were measured. Results: In vivo, administration of RES prevented HFD and LPS induced dysfunction of serum lipids including TC (total cholesterol), TG (triglyceride), LDL-C (low density lipoprotein cholesterol) and HDL-C (high density lipoprotein cholesterol), ameliorated the thickened coronary artery wall and decreased the areas of atherosclerotic lesion on aortas. Besides, RES decreased the number of CD4+ T cells in peripheral blood, decreased the expression of CD25 and CD44, but not affected the expression of L-selectin (CD62L). In vitro, RES decreased the expression of Ki67, CD25 and CD44 in CD4+ T cells. Moreover, RES increased the secretion of IL-2, IL-10 and TGF-β1, decreased IL-6. In addition, RES decreased both the mRNA and protein level of Dnmt1 and Dnmt3b in CD4+ T cells.Conclusion: These results indicated that RES ameliorated AS induced by HFD companied with LPS in ApoE-/- mice, inhibited the proliferation and activation of CD4+ T cells and regulated the expression of Dnmt1 and Dnmt3b.

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“…We have previously demonstrated a decrease in Treg/Th17 ratio in patients with carotid atherosclerotic plaques (AP) > 30% [10]. The prognostic significance of reduced IL-10-producing CD4þ T-cell blood frequencies for coronary atherosclerosis progression was observed [11]. Also in critical carotid artery stenosis, an increase of circulating IL-10-producing CD4þ T-cells has been demonstrated, suggesting that such Treg subpopulation can exert a protective role against aortic wall rupture [12].…”

Section: Introductionmentioning

confidence: 99%

The severity of internal carotid artery stenosis is associated with the circulating Th17 level

Filatova

Потехина

Pylaeva

et al. 2020

Heliyon

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Immune and inflammatory reactions contribute to the progression of atherosclerosis. The walls of the different arteries and segments of the arteries have heterogeneous haemodynamic and histological features. We aimed to explore the relationship between the circulating T-cell subsets and the abundance of carotid atherosclerosis in different segments of carotid arteries. Methods: 70 patients underwent ultrasound duplex scanning to determine the degree of stenosis of the common carotid artery (CCA), the CCA bifurcation or the internal carotid artery (ICA). The blood frequencies of T-, B-, NKcells, regulatory T cells (Treg), activated T-helpers (Th), IL10-producing Th, Th1 and Th17, as well as blood levels of hsCRP, sCD25, IL10 and IL17a were assessed. Results: The frequencies of Th17 were increased in patients with ICA stenosis >35% and >50% vs. patients with ICA stenosis <35%. Th17 blood level 0.55 % of lymphocytes was associated with more severe stenosis of ICA ), p < 0.05 for ICA stenosis of 35-50% and 6.8 (1.3-35.0), p < 0.05 for ICA stenosis >50%). BMI positively correlated with the CCA bifurcation stenosis degree (r ¼ 0.33, p < 0.05). Conclusion:The severity of ICA stenosis can be associated with the circulating Th17 level.

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Low Blood Content of IL-10-Producing CD4+ T Cells as a Risk Factor for Progression of Coronary Atherosclerosis

Cited by 10 publications

References 14 publications

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

Resveratrol Ameliorates Atherosclerosis Induced by High-fat Diet and LPS in ApoE-/- Mice and Inhibits the Activation of CD4+ T Cells

The severity of internal carotid artery stenosis is associated with the circulating Th17 level

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