Low birthweight infants and total parenteral nutrition immediately after birth. II. Randomised study of biochemical tolerance of intravenous glucose, amino acids, and lipid.

Murdock, N.; Crighton, A.; Nelson, L.M.; Forsyth, J. S.

doi:10.1136/fn.73.1.f8

Cited by 46 publications

(29 citation statements)

References 30 publications

(7 reference statements)

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“…14 This might be related to the stimulating effect on the insulin secretion that the early introduction of amino acids produces. 15 In VLBW premature infants, the incidence of hyperglycemia is frequent because the endogenous production of glucose is not suppressed either by the exogenous intakes of nutrients or by the infusion of lipids. 16 Plasmatic values of triglycerides in the aggressive group were in the normal range, similar to that found by other authors.…”

Section: Discussionmentioning

confidence: 99%

Early and aggressive nutritional strategy (parenteral and enteral) decreases postnatal growth failure in very low birth weight infants

Dinerstein¹,

Nieto²,

Solana³

et al. 2006

J Perinatol

149

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Objective: To compare postnatal growth and nutritional deficits after the implementation of two different nutritional strategies in two consecutives periods of time.Methods: An early and aggressive nutritional regimen was used in a cohort of 117 very low birth weight (VLBW) infants. Amino acids were administered at the rate of 1.5 g/kg/day along with 5.6 mg/k/min of glucose flow on day 1 of life, and progressively increased to 4 g/kg/day and 13 mg/kg/min. Intravenous lipids were started at 0.5 g/kg/day at 24 h from birth, and increased to 3.5 g/kg/day; enteral feeding was begun at day 1 of life. Uni-and multivariate analyses were used to compare this group with the conventional group of 65 VLBW infants conservatively fed.Results: Univariate analysis showed that in the aggressive group there was a 66% reduction in the risk of post natal malnutrition at 40 weeks of postmenstrual age (OR 0.34; 95% CI 0.17-0.67). This difference persisted in the multivariate analysis. Energy and protein deficits were lower in the aggressive group (P<0.001).Conclusions: Early and aggressive introduction of total parenteral nutrition and enteral feeding resulted in better growth in weight, length and head circumference, and a reduction of nutritional deficits at 40 weeks of postmenstrual age.

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Section: Discussionmentioning

confidence: 99%

Early and aggressive nutritional strategy (parenteral and enteral) decreases postnatal growth failure in very low birth weight infants

Dinerstein¹,

Nieto²,

Solana³

et al. 2006

J Perinatol

149

View full text Add to dashboard Cite

show abstract

“…We demonstrated that starting protein within 4 hours of birth (in the form of intravenous [IV] amino acids [AAs] in PN) is associated with enhanced blood glucose control and reduced insulin use in very preterm infants 12 . Although the exact mechanism for this effect is unknown, the effect of AAs on insulin secretion is well described in preterm infants 3 , 13 . It is equally well described that some AAs are more potent secretagogues than others.…”

Section: Introductionmentioning

confidence: 99%

Plasma Arginine Levels and Blood Glucose Control in Very Preterm Infants Receiving 2 Different Parenteral Nutrition Regimens

Burgess

Morgan

Mayes³

et al. 2013

J Parenter Enteral Nutr

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“…During the first week of life, the three infants had high glucose requirement; ≥7–8 mg/kg/min is practically diagnostic of hyperinsulinism . It is well known that early administration of amino acids enhances endogenous insulin secretion . Since we routinely provided preterm infants with early aggressive intravenous nutrition, most of them required a glucose infusion rate of 7–10 mg/kg/min to maintain normoglycemia during the first days of life.…”

Section: Discussionmentioning

confidence: 99%

Glycemic variability in preterm infants receiving intermittent gastric tube feeding: Report of three cases

Mizumoto

Honda

Ueda

et al. 2013

Pediatrics International

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Late-onset hypoglycemia (day 12-16, blood glucose <50 mg/dL) was detected in three preterm infants (birthweight 998-1780 g; gestational age 27-30 weeks) by routine screening. All infants showed high serum insulin levels and extremely low ketone levels at the time of hypoglycemia. Continuous glucose monitoring was conducted at 31-34 weeks' postconceptual age when the infants were receiving intermittent gastric tube feeding with no intravenous glucose infusion. The continuous glucose monitoring results showed characteristic postprandial glucose increases and subsequent sharp deceases along with many hyper- and hypoglycemic events. This fluctuating pattern disappeared at 38-40 weeks' postconceptual age. These observations suggest that prolonged insulin oversecretion may be associated with early aggressive intravenous nutrition, and that large glycemic variability is a common feature of tube-fed preterm infants that can be explained by immature glucose homeostasis.

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Low birthweight infants and total parenteral nutrition immediately after birth. II. Randomised study of biochemical tolerance of intravenous glucose, amino acids, and lipid.

Abstract: This randomised study aimed to compare the biochemical tolerance of three parenteral regimens administered during the first 48 hours of life. Twenty nine infants were randomised to either: (a) glucose 10%; (b) glucose 100/o/amino acids; (c) glucose 100/olamino acids/lipid.

Cited by 46 publications

References 30 publications

Early and aggressive nutritional strategy (parenteral and enteral) decreases postnatal growth failure in very low birth weight infants

Early and aggressive nutritional strategy (parenteral and enteral) decreases postnatal growth failure in very low birth weight infants

Plasma Arginine Levels and Blood Glucose Control in Very Preterm Infants Receiving 2 Different Parenteral Nutrition Regimens

Glycemic variability in preterm infants receiving intermittent gastric tube feeding: Report of three cases

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