Low Back Pain and Lumbar Spine Osteoarthritis: How Are They Related?

Goode, Adam P.; Carey, Timothy S.; Jordan, Joanne M.

doi:10.1007/s11926-012-0305-z

Cited by 130 publications

(87 citation statements)

References 66 publications

(76 reference statements)

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“…Disc space narrowing has been consistently associated with LBP in population-based studies [13][14][15]. However, vertebral osteophytes [14], endplate sclerosis [14], spondylolisthesis [16], and facet joint osteoarthritis [13] have all been debated as a source of LBP. Challenges in case definitions of LBP and differences in populations studied (i.e., community-based or occupationalbased) further create challenges to understanding this complex relationship.…”

Section: Introductionmentioning

confidence: 99%

The association between lumbar spine radiographic features and low back pain: A systematic review and meta-analysis

Raastad¹,

Reiman

Coeytaux

et al. 2015

Seminars in Arthritis and Rheumatism

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Section: Introductionmentioning

confidence: 99%

The association between lumbar spine radiographic features and low back pain: A systematic review and meta-analysis

Raastad¹,

Reiman

Coeytaux

et al. 2015

Seminars in Arthritis and Rheumatism

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“…9 In this case, the onset of symptoms is acute or chronic, pain worsens with movement, and there is no nocturnal pain. It is very often associated with the assumption of antalgic abnormal postures.…”

Section: Low Back Pain Associated With Movementmentioning

confidence: 89%

Clinical Assessment of Low Back Pain: A Neurosurgical Point of View

Landi

Grasso

Colistra

et al. 2016

IJRSMS

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The diagnosis of low back pain (LBP) is complex and multifactorial, and a clear etiology responsible for the symptoms is often not detectable. Clinical history and neurological examination are essential for differential diagnosis, because they allow the identification of the specific pathology. The radiological investigation allows to confirm diagnosis, but the indication must always be correlated with clinical findings to not perform unnecessary diagnostic procedures. Management of LBP can involve many specialists -neurosurgeon, orthopedist, physiatrist, physiotherapist -everyone with different knowledge and experience because very often the cause is multifactorial. However, it is mandatory to clarify diagnosis of LBP; in this way, the clinical pathway is fundamental to understand pathogenesis and to determine appropriate treatment.

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“…2,15 Lower back pain in postmenopausal women is the most common clinical manifestation of the degeneration process over the spine main areas/segments that are most mobile lumbar segments. 16,17 …”

Section: Discussionmentioning

confidence: 99%

The role of aging, body mass index and estrogen on symptomatic lumbar osteoarthritis in post-menopausal women

Suyasa

Setiawan

2016

Int J Res Med Sci

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Background: Low back pain is a common complaint which is always found in old age due to degeneration process. Degeneration process of spine, especially in the lumbar region is called lumbar osteoarthritis (OA). Various factors are thought to be the cause of lumbar OA, including primarily due to hormonal changes of estrogen and increase of age and body mass index in postmenopausal women. Methods: The purpose of this study is to determine the role of hormonal changes pathogenesis in lumbar osteoarthritis in postmenopausal women and its correlation with age and body mass index. Cross sectional analytic method had been conducted to determine the role of age, body mass index and estrogen for lumbar OA in postmenopausal women. The study was conducted in Sanglah General Hospital from October 2015 until March 2016 by anthropometric measures and blood samples. Results: From 196 samples showed that the estrogen deficiency in postmenopausal women have a correlation with the symptomatic lumbar OA (r=0.252, p = 0.000). While age and the body mass index in postmenopausal women has a correlation with symptomatic lumbar OA (r = 0.150 and 0.198, p = 0.000 and 0.013). Conclusions:The aging process, body mass index and estrogen deficiency correlated with the symptomatic OA lumbar in post-menopausal women. Suyasa IK et al. Int J Res Med Sci. 2016 May;4(5):1325-1328 International 4-6 These three components are familiar with the three joint complex interplay in lumbar osteoarthritis. There are 3 clinical signs and stages of the degeneration of spinal biomechanics i.e. disc dysfunctions, instability and stability. Keywords7 Spinal degeneration include disc degeneration (DD), facet joint osteoarthritis (OA Facet joint), changes in components of muscle and ligament degeneration. [5][6][7] Hormonal changes that occur during menopause will affect the occurrence of osteoarthritis. In postmenopausal women, the use of HRT (Hormone Replacement Therapy) lowered radiological progression. Estrogen stimulates proteoglycan changes in cartilage, either directly or indirectly through cytokines. 8,9 Estrogen directly affects the tissue by estrogen receptors on human articular chondrocytes and indirectly by secondary messenger.10 Estrogen affects the levels of cytokines in vitro and in vivo. Identification over two estrogen receptors ERα and ERβ on chondrocyte prove that cartilage is sensitive to estrogen.11 Several in vivo and in vitro studies also showed that chondrocytes respond to estrogen and affect its metabolism. 11,12 METHODSThe study was conducted from October 2015 until March 2016 at the Sanglah General Hospital Denpasar Bali. The aim of this study is to prove the correlation of age, body mass index and hormonal changes with symptomatic lumbar osteoarthritis in postmenopausal women.This study is a cross sectional analytic design with the sample are post-menopausal women population with consecutive sampling method.One hundred and ninety six post-menopausal women from the population were taken the anthropometry measure i.e. body weight...

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Low Back Pain and Lumbar Spine Osteoarthritis: How Are They Related?

Cited by 130 publications

References 66 publications

The association between lumbar spine radiographic features and low back pain: A systematic review and meta-analysis

The association between lumbar spine radiographic features and low back pain: A systematic review and meta-analysis

Clinical Assessment of Low Back Pain: A Neurosurgical Point of View

The role of aging, body mass index and estrogen on symptomatic lumbar osteoarthritis in post-menopausal women

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