Low-artifact and long depth of field photoacoustic microscopy using a Gaussian-weighted annular array

Liu, Zhipeng; Tao, Chao; Liu, Xiaojun

doi:10.7567/1882-0786/ab0a92

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…To obtain a fast inertialess scanning, an extended depth-of-field lens has been used in PAM, but the PAM is limited by that the optical or acoustic energy is difficult to be evenly distributed in the depth direction [28]. Besides, optical or acoustic fast-focusdepth-scanning schemes have been reported for enlarging the range of focal region of PAMs by varifocal lens [29][30][31], annular array detectors [31,32] and multiple sono-opto detectors [24,33]. In such cases, the limitation of those existing PADs is only one scheme that the acoustic or optical focusing technology is typically adopted, which maybe not enough to meet the need of a large range of confocal region.…”

Section: Introductionmentioning

confidence: 99%

Three dimensional confocal photoacoustic dermoscopy with an autofocusing sono‐opto probe

Wang

Zuo

et al. 2022

Journal of Biophotonics

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Photoacoustic dermoscopy (PAD) is uniquely positioned for the diagnosis and assessment of dermatological conditions because of its ability to visualize optical absorption contrast in vivo in three dimensions. In this Letter, we developed a 3D confocal PAD (3D-CPAD) equipped with an autofocusing sono-opto probe to facilitate the reconstruction of high-spatial-resolution imaging of skin with multilaminate structures in depth direction. The autofocusing sono-opto probe integrated a 10-mm electrowetting-based varifocal lens to automatically control the acoustic and optical confocal length, and an annular ultrasonic detector with a mid-frequency of ~32.8 MHz is coaxially configured for receiving photoacoustic signals. Using this sono-opto probe, the acoustic and optical confocal length-shifting range from ~7 to 43 mm with high image contrast and spatial resolution in the 3D image reconstruction. Autofocusing property tests and 3D human skin in vivo imaging were carried out to demonstrate the imaging capability of the 3D-CPAD for potential clinical foreground in noninvasive biopsies of skin disease.

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Section: Introductionmentioning

confidence: 99%

Three dimensional confocal photoacoustic dermoscopy with an autofocusing sono‐opto probe

Wang

Zuo

et al. 2022

Journal of Biophotonics

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“…Based on the photoacoustic effect, biomedical imaging technology like photoacoustic microscopy (PAM), photoacoustic tomography (PAT) and photoacoustic endoscope (PAE) has developed rapidly. [11][12][13][14] The photoacoustic effect has also been used to make optoacoustic transducers. [15][16][17][18][19][20] This kind of transducer can generate high-frequency ultrasound (>50 MHz) while achieving element size and spacing on the order of several microns.…”

mentioning

confidence: 99%

Optical and ultrasonic dual-sensitive sensor and its application in photoacoustic microscopy

Xu,

Wu,

Tao

et al. 2024

Appl. Phys. Express

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Multi-modality imaging is significant for biomedical applications. We propose a dual-sensitive sensor to simultaneously detect optical and ultrasonic signals. Based upon the classical piezoelectric structure, we attach a photosensitive layer made of Carbon Nanotubes-Polydimethylsiloxane (CNTs–PDMS) composite to the surface. The photosensitive layer absorbs light and converts it into ultrasound, while allowing acoustic energy to transmit through concurrently. After optimizing the ratio of PDMS to CNTs, we increase the sensor’s light detection sensitivity and maintain the ultrasound detection sensitivity. Finally, the successful implementation in mouse ear optical attenuation–photoacoustic imaging demonstrates the dual-sensitive sensor’s potential application in multi-modality imaging.

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“…2) In recent years, endoscopic technology has been widely used to detect colorectal cancer by providing intuitive tissue morphology and vascular network information. [3][4][5][6][7][8] Visible light endoscopes are usually used to visualize the rectal wall to diagnose various diseases. However, due to the lack of depth resolution information and limited vascular sensitivity, the changes of epithelial dysplasia in the early stage of cancer development cannot be clearly visualized.…”

mentioning

confidence: 99%

Real-time optical-resolution photoacoustic endoscope

Sun¹,

Wang²,

Zhang³

et al. 2021

Appl. Phys. Express

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Currently, the reported endoscopic system cannot meet the necessary conditions for real-time and optical-resolution clinical application simultaneously. In this study, by utilizing a high-repetition-rate laser and optimizing the overall structure of the probe, a real-time optical-resolution photoacoustic endoscope was developed, which could image targets in real time while maintaining a relatively constant lateral resolution. The endoscopic system has a best-resolution of 19 μm and a real-time imaging speed of 25 Hz. Experimental results demonstrate that this approach will push the promotion and commercialization of photoacoustic endoscopic imaging in a variety of preclinical and clinical applications.

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Low-artifact and long depth of field photoacoustic microscopy using a Gaussian-weighted annular array

Cited by 8 publications

References 25 publications

Three dimensional confocal photoacoustic dermoscopy with an autofocusing sono‐opto probe

Three dimensional confocal photoacoustic dermoscopy with an autofocusing sono‐opto probe

Optical and ultrasonic dual-sensitive sensor and its application in photoacoustic microscopy

Real-time optical-resolution photoacoustic endoscope

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