Low Antioxidant Enzyme Levels and Oxidative Stress in Laryngopharyngeal Reflux (LPR) Patients

Bulut, Fuat; Tetiker, Aylin Türksever; Çelikkol, Aliye; Yılmaz, Ahsen; Ballica, Basak

doi:10.1016/j.jvoice.2021.05.018

Cited by 4 publications

(5 citation statements)

References 57 publications

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“…Additionally, most subjects, accounting for 54% (n=27), fell within the age group of 30-49 years, with a mean age of 36.08+11.20 years. These findings closely resemble the results of a study conducted by Toppo et al in India [15]. A statistically significant but slight trend was identified, linking the severity of heartburn with increasing age.…”

Section: Discussionsupporting

confidence: 90%

“…After receiving proton pump inhibitor treatment for 6 to 8 weeks, 87.5% of subjects experienced relief from their symptoms, while in 12.5% of cases, symptoms persisted despite treatment. Locky et al conducted a study that reported an 82% response to medical treatment, which is consistent with the findings of Toppo et al [15,22]. Similarly, in a study by Zagari et al, dysphagia resolved in 83% of patients after oncedaily PPI treatment [23].…”

Section: Discussionsupporting

confidence: 65%

“…Yang et al reported that acid regurgitation was the most frequent and bothersome symptom among GERD patients [16]. Another study in India discovered a 32% prevalence of GERD in APD [15]. Several studies have reported that 21-37% of individuals experience heartburn at least once a month, and 13-25% experience it at least once a week or more frequently [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

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Histopathological Study of Gastro Esophageal Reflux Disease (GERD) and Its Correlation with Endoscopic Finding

Haque,

Hira,

Hossain

et al. 2023

Open Access J Intern Med

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Background: Gastro esophageal reflux disease (GERD) is a common burden on health care resources in the Western world and deteriorates the health-related quality of life of those affected, but its manifestations in the general population are as yet unclear Aim of the Study:The aim of the study was to find out the Histopathological findings of Gastro Esophageal Reflux Disease and its correlation with Endoscopic finding.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathological Study of Gastro Esophageal Reflux Disease (GERD) and Its Correlation with Endoscopic Finding

Haque,

Hira,

Hossain

et al. 2023

Open Access J Intern Med

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“…Laryngopharyngeal reflux disease (LPRD) is caused by the reflux of gastric contents, including acid, pepsin, and bile juice, which causes damage to the larynx and pharynx [1]. Notably, several previous studies have reported that reactive oxygen species (ROSs) play a key role in the development of LPRD [2]. As the previous studies on esophagitis caused by ROS [3][4][5], ROS may cause pharynx and larynx tissue damage, and the use of antioxidants may reduce the tissue damage caused by ROS.…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway

Kim

Jung

et al. 2022

J Mol Med

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Laryngopharyngeal reflux disease (LPRD) is caused by pharyngeal mucosal damage due to the reflux of gastric contents, including acid, pepsin, and bile juice. Our previous study has demonstrated that LPRD is associated with the cleavage of E-cadherin, which is facilitated by the acid-activated matrix metalloproteinase-7 (MMP-7); however, the mechanism by which the acid activates MMP-7 remains unclear. The purpose of this study was to investigate the mechanism by which MMP-7 is activated in the pharyngeal epithelial cells that are exposed to acid. The levels of reactive oxygen species (ROS) were measured in the epithelial cells exposed to acid. To investigate the signaling mechanism of ROS in the expression of MMP-7, the mechanism of action of the mitogen-activated protein kinase was examined. The expression of various signaling factors was determined, according to the presence or absence of each inhibitor in the acid-exposed pharyngeal epithelial cells. To identify changes in the cleavage of E-cadherin, the integrity of the mucosal membrane was assessed using a transepithelial permeability test. We found that acid exposure increased the levels of ROS, phosphorylated-extracellular signal-regulated kinase (p-ERK) 1/2, and phosphorylated-c-Jun (p–c-Jun) in pharyngeal epithelial cells. The ROS inhibitor reduced the expression of p-ERK and MMP-7, while the ERK inhibitor reduced the expression of p–c-Jun and MMP-7. Moreover, the c-Jun inhibitor reduced the expression of MMP-7 and blocked the degradation of E-cadherin. In addition, decrease in the levels of immunostained E-cadherin and increase in transepithelial permeability after acid exposure were collectively alleviated by the inhibitors of ROS, ERK, and c-Jun. The degradation of E-cadherin that occurs after human mucosal cells are exposed to acid appears to be caused by an increase in the expression of MMP-7 via the ROS/ERK/c-Jun pathway, which is thought to be an important mechanism associated with the development of LPRD. Key messages • ROS is triggered when reflux occurs. • ROS regulates the transcription factor c-Jun via the ERK pathway. • The increase in MMP-7 that induces LPRD is induced via the ROS/ERK/c-Jun pathway. • This study revealed for the first time the expression mechanism of MMP-7, which is one of the causes of LPRD.

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“…CAT has a prime role in regulating the cellular level of hydrogen peroxide, and its hydrogen peroxide catabolism protects the cells from oxidative assault, for example, by securing the pancreatic β cells from hydrogen peroxide injury [5,7]. CAT deficiency or malfunctioning is associated with many diseases such as diabetes mellitus, vitiligo, cardiovascular diseases, Wilson disease, hypertension, anemia, some dermatological disorders, Alzheimer's disease, bipolar disorder, and schizophrenia [8]. CAT has a prime role in regulating the cellular level of hydrogen peroxide, and its hydrogen peroxide catabolism protects the cells from oxidative assault, for example, by securing the pancreatic β cells from hydrogen peroxide injury [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Correlation between oxidative stress and clopidogrel drug in Iraqi patients with coronary artery disease

Khudair

Al-Ani

2022

ijhs

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Background: Coronary Artery Disease (CAD) is one of the largest causes of mortality worldwide. Clopidogrel, antiplatelet drug, has been widely used for management of CAD. The current study aimed to investigate the effect of clopidogrel on the oxidative stress in CAD patients. Methods: One hundred CAD patients, who were followed-up for 5 days after receiving clopidogrel, and 50 healthy volunteers were included in this study. Parameters include catalase (CAT), total antioxidant capacity (TAC), total oxidant capacity (TOC), total protein, albumin, and globulins were determined before and after treatment with clopidogrel. Results: CAT, TAC, and Tp were significantly decreased (P<0.0001) in CAD patients compared to healthy control and the levels of these parameters were returned to increase after receiving clopidogrel. However, TOC level was markedly increased (P<0.0001) in CAD patients and returned to decrease after treating with clopidogrel. Receiver operating characteristic curve showed that CAT gave a higher sensitivity (68-73%) and specificity (72%) as an indicator for monitoring of CAD progression. Conclusion: CAT activity and TAC were significantly increased as a response of receiving clopidogrel which is helpful to reduce the risk of CAD through scavenging of oxidants formation. These results also present CAT as a predictor variable of clopidogrel action.

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Low Antioxidant Enzyme Levels and Oxidative Stress in Laryngopharyngeal Reflux (LPR) Patients

Cited by 4 publications

References 57 publications

Histopathological Study of Gastro Esophageal Reflux Disease (GERD) and Its Correlation with Endoscopic Finding

Histopathological Study of Gastro Esophageal Reflux Disease (GERD) and Its Correlation with Endoscopic Finding

Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway

Correlation between oxidative stress and clopidogrel drug in Iraqi patients with coronary artery disease

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