Low- and medium-pressure UV inactivation of microsporidia Encephalitozoon intestinalis

Huffman, Debra E.; Gennaccaro, Angela; Rose, Joan B.; Dussert, Bertrand W.

doi:10.1016/s0043-1354(01)00528-0

Cited by 34 publications

(19 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This facilitates investigations of their basic biology (102,127) and also allows for easy assessment of drugs (80) or disinfection schemes (118,147,150,173), which has become an issue since human-pathogenic microsporidia have been discovered in surface waters (57,89,90,103,150,255,272).…”

Section: Diagnostic Techniquesmentioning

confidence: 99%

Zoonotic Potential of the Microsporidia

2005

View full text Add to dashboard Cite

Microsporidia are long-known parasitic organisms of almost every animal group, including invertebrates and vertebrates. Microsporidia emerged as important opportunistic pathogens in humans when AIDS became pandemic and, more recently, have also increasingly been detected in otherwise immunocompromised patients, including organ transplant recipients, and in immunocompetent persons with corneal infection or diarrhea. Two species causing rare infections in humans, Encephalitozoon cuniculi and Brachiola vesicularum, had previously been described from animal hosts (vertebrates and insects, respectively). However, several new microsporidial species, including Enterocytozoon bieneusi, the most prevalent human microsporidian causing human immunodeficiency virus-associated diarrhea, have been discovered in humans, raising the question of their natural origin. Vertebrate hosts are now identified for all four major microsporidial species infecting humans (E. bieneusi and the three Encephalitozoon spp.), implying a zoonotic nature of these parasites. Molecular studies have identified phenotypic and/or genetic variability within these species, indicating that they are not uniform, and have allowed the question of their zoonotic potential to be addressed. The focus of this review is the zoonotic potential of the various microsporidia and a brief update on other microsporidia which have no known host or an invertebrate host and which cause rare infections in humans

show abstract

Section: Diagnostic Techniquesmentioning

confidence: 99%

Zoonotic Potential of the Microsporidia

2005

View full text Add to dashboard Cite

show abstract

“…Only two reports have demonstrated the ability of low-and medium-pressure ultraviolet (UV) light to inactivate > 3.6 log 10 of E. intestinalis spores in water at a dose of 6 mJ/cm 2 or higher as determined using a cell culture approach (Huffman et al, 2002) and a 3 log 10 at 8.43 mW s/cm 2 . The results indicated that UV light at dosages utilized for drinking water treatment is capable of achieving high levels of inactivation of E. intestinalis spores (Huffman et al, 2002). In one study focusing on the effect of solar disinfection on the viability of intestinal pathogens, the best results were tubes exposure to sun for 24 hr in summer, where C. parvum, G. duodenalis, and Cyclospora cayetanensis wer…”

Section: Physical Disinfection (Ultraviolet)mentioning

confidence: 99%

Microsporidia

Feng¹,

Lli²

2019

Water and Sanitation for the 21st Century: Health and Microbiological Aspects of Excreta and Wastewater Management (Global Wate

View full text Add to dashboard Cite

“…Ultraviolet disinfection system is capable to transfer electromagnetic energy into genetic material (DNA or RNA) of an organism, where it destroys cell´s ability to reproduce (EPA, 1999a). Huffman et al (2002) demonstrated that UV light at dosages utilized for drinking water treatment is capable of achieving high levels of inactivation of Microsporidia. For a low-and medium-pressure UV light, C * t values were found to be 6 mWs/cm 2 for a 3.6-log 10 reduction of E. intestinalis (Huffman et al, 2002), and 8.4 mWs/cm 2 for a 3-log 10 reduction, i. e. 99.9 % reduction of E. intestinalis with low pressure UV at 25 °C .…”

Section: Disinfection Of Microsporidia In the Watermentioning

confidence: 99%

“…Huffman et al (2002) demonstrated that UV light at dosages utilized for drinking water treatment is capable of achieving high levels of inactivation of Microsporidia. For a low-and medium-pressure UV light, C * t values were found to be 6 mWs/cm 2 for a 3.6-log 10 reduction of E. intestinalis (Huffman et al, 2002), and 8.4 mWs/cm 2 for a 3-log 10 reduction, i. e. 99.9 % reduction of E. intestinalis with low pressure UV at 25 °C . Even though exact mechanism by which chlorine destroys pathogens has not been elucidated, it can cause oxidation of enzymes and amino acids, inhibition of protein synthesis, decreased oxygen and nutrient uptake and DNA destruction (CDC, 2008).…”

Section: Disinfection Of Microsporidia In the Watermentioning

confidence: 99%

Phylum Microsporidia: Dangerous Waterborne Pathogens, A Review

Kalinová¹,

Bálent²

2015

IJSRES

View full text Add to dashboard Cite

Phylum Microsporidia comprises from various species, number of which are pathogenic and capable of infecting humans by the means of water. Important human pathogens Enterocytozoon bieneusi and Encephalitozoon intestinalis were detected in both, ground and surface waters. Other Microsporidia species such as Encephalitozoon cuniculi and Encephalitozoon hellem but also Pleistophora spp. and Vittaforma corneae were also detected in water. Even though disinfection and filtration of drinking water is usually effective against these pathogens, malfunctions in water treatment system can lead to epidemics, such as one that occurred in 1995 in Lyon where 200 people got infected. Therefore pathogens from genus Microsporidia should be routinely monitored in drinking water, but also in water sources and recreational areas.

show abstract

Low- and medium-pressure UV inactivation of microsporidia Encephalitozoon intestinalis

Cited by 34 publications

References 7 publications

Zoonotic Potential of the Microsporidia

Zoonotic Potential of the Microsporidia

Microsporidia

Phylum Microsporidia: Dangerous Waterborne Pathogens, A Review

Contact Info

Product

Resources

About