Low and high homocysteine are associated with mortality independent of B group vitamins but interactive with cognitive status in a free-living elderly cohort

Xiu, Lili; Lee, Meei-Shyuan; Wahlqvist, Mark L.; Chen, Rosalind Chia-Yu; Huang, Yi-Chen; Chen, Kuan‐Ju; Li, Duo

doi:10.1016/j.nutres.2012.09.005

Cited by 19 publications

(13 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Initially, 5,651 potential studies were identified from the PubMed, Embase, Web of Science, and Cochrane Library databases; however, most of them were excluded according to the exclusion criterion. Finally, 11 eligible studies 7, 9–18 with a total of 27,737 participants (4,110 deaths) were included. Of the included studies, 3 studies were performed in Asia, 2 in North America, and 6 in Europe.…”

Section: Resultsmentioning

confidence: 99%

“…In this meta-analysis, subgroup analyses were further conducted to investigate the potential inter-study heterogeneity and examine the robustness of primary results 31 . We divided the subgroups as follows: geographical location (Asia 16–18 , North America 11, 12 , or Europe 9, 10, 13–15, 32 ), sex (male 10, 16, 17 or female 10, 16 ), duration of follow-up (<7 years 7, 9, 11, 14, 15, 17 or ≥7 years 10, 12, 13, 16, 18 ), sample size (<1000 13–15 or ≥1000 7, 9–12, 16–18 ), fasting status (yes 7, 11, 14, 15 or no 12, 13, 16 ), and NOS score (≤7 7, 11, 17 or >7 9, 10, 12–16, 18 ). We also performed analyses stratified by whether the studies had adjusted for potential confounding factors, including smoking, alcohol consumption, BMI, physical activity, history of CVD, history of diabetes, and serum vitamin B12/folate.…”

Section: Methodsmentioning

confidence: 99%

“…In several follow-up studies, Hcy levels were reported to be associated with all-cause mortality 6–8 . For example, Vollset SE et al .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies

Fan

Zhang

Zhong

2017

Sci Rep

View full text Add to dashboard Cite

Plasma homocysteine (Hcy) levels may be associated with all-cause mortality risk. However, the results of this association are conflicting and the dose-response relationship between them has not been clearly defined. In this meta-analysis, we conducted a systematic literature search of the PubMed, Embase, Web of Science and Cochrane Library for the relevant articles dated up to February 2017. Pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) were calculated to evaluate the estimates, and the dose-response relationship was estimated using a restricted cubic spline model. Eleven prospective studies (4,110 deaths among 27,737 individuals) were included. The summary RR of all-cause mortality for the highest Hcy category vs. the lowest Hcy category was 1.80 (95% CI: 1.51, 2.14) with the random effects model. In dose-response meta-analysis, Hcy levels were significantly associated with all-cause mortality risk in a linear fashion (p nonlinearity = 0.255), and the risk of all-cause mortality increased by 33.6% for each 5 µmol/L increase in Hcy levels (RR = 1.336, 95% CI: 1.254–1.422, p < 0.001). Findings from this dose-response meta-analysis suggest that Hcy levels are linearly and positively associated with risk of all-cause mortality.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies

Fan

Zhang

Zhong

2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…A review of both cross-sectional and casecontrol studies supports the thesis that higher thiamin intakes support better cognition but still leaves many unanswered questions (66). For example, in the 1999-2000 Nutrition and Health Survey of elderly individuals in Taiwan (N = 1,412) inadequate intakes of thiamin, as well as of B 6 and B 12 , accounted, in part, for cognitive impairment (67). Similarly, other studies have shown that thiamin status was lower in those with cognitive impairment than in normal control subjects (66,68,69).…”

Section: Thiaminmentioning

confidence: 94%

Full Issue PDF

2017

Cereal Foods World

View full text Add to dashboard Cite

“…Low vitamin B6 intake has been associated with a reduced risk of Alzheimer’s disease [178] in older Americans. Only one study from Taiwan has investigated the role of riboflavin status and found a significant association with cognitive dysfunction, which was assessed using only a short portable mental status questionnaire and cognition was not the primary outcome [179]. …”

Section: Emerging Roles Of B-vitamin Status In Preventing Diseasesmentioning

confidence: 99%

Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing

et al. 2016

View full text Add to dashboard Cite

The potential protective roles of folate and the metabolically related B-vitamins (vitamins B12, B6 and riboflavin) in diseases of ageing are of increasing research interest. The most common cause of folate and riboflavin deficiencies in older people is low dietary intake, whereas low B12 status is primarily associated with food-bound malabsorption, while sub-optimal vitamin B6 status is attributed to increased requirements in ageing. Observational evidence links low status of folate and the related B-vitamins (and/or elevated concentrations of homocysteine) with a higher risk of degenerative diseases including cardiovascular disease (CVD), cognitive dysfunction and osteoporosis. Deficient or low status of these B-vitamins alone or in combination with genetic polymorphisms, including the common MTHFR 677 C → T polymorphism, could contribute to greater disease risk in ageing by causing perturbations in one carbon metabolism. Moreover, interventions with the relevant B-vitamins to optimise status may have beneficial effects in preventing degenerative diseases. The precise mechanisms are unknown but many have been proposed involving the role of folate and the related B-vitamins as co-factors for one-carbon transfer reactions, which are fundamental for DNA and RNA biosynthesis and the maintenance of methylation reactions. This review will examine the evidence linking folate and related B-vitamins with health and disease in ageing, associated mechanisms and public health implications.

show abstract

Low and high homocysteine are associated with mortality independent of B group vitamins but interactive with cognitive status in a free-living elderly cohort

Cited by 19 publications

References 67 publications

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies

Full Issue PDF

Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing

Contact Info

Product

Resources

About